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Molecular Imaging and Contrast Agent Database (MICAD): Evolution and Progress

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Abstract

The purpose of writing this review is to showcase the Molecular Imaging and Contrast Agent Database (MICAD; www.micad.nlm.nih.gov) to students, researchers, and clinical investigators interested in the different aspects of molecular imaging. This database provides freely accessible, current, online scientific information regarding molecular imaging (MI) probes and contrast agents (CA) used for positron emission tomography, single-photon emission computed tomography, magnetic resonance imaging, X-ray/computed tomography, optical imaging and ultrasound imaging. Detailed information on >1,000 agents in MICAD is provided in a chapter format and can be accessed through PubMed. Lists containing >4,250 unique MI probes and CAs published in peer-reviewed journals and agents approved by the United States Food and Drug Administration as well as a comma separated values file summarizing all chapters in the database can be downloaded from the MICAD homepage. Users can search for agents in MICAD on the basis of imaging modality, source of signal/contrast, agent or target category, pre-clinical or clinical studies, and text words. Chapters in MICAD describe the chemical characteristics (structures linked to PubChem), the in vitro and in vivo activities, and other relevant information regarding an imaging agent. All references in the chapters have links to PubMed. A Supplemental Information Section in each chapter is available to share unpublished information regarding an agent. A Guest Author Program is available to facilitate rapid expansion of the database. Members of the imaging community registered with MICAD periodically receive an e-mail announcement (eAnnouncement) that lists new chapters uploaded to the database. Users of MICAD are encouraged to provide feedback, comments, or suggestions for further improvement of the database by writing to the editors at micad@nlm.nih.gov.

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Acknowledgments

We thank Jeremiah McAdams for his assistance with the writing of this review. Funding for the Molecular Imaging and Contrast Agent Database is provided by the Intramural Research Program of the National Institutes of Health.

Conflict of interest disclosure

The authors declare they have no conflict of interest.

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Authors and Affiliations

  1. National Center of Biotechnology Information, National Library of Medicine, 8600 Rockville Pike, Bethesda, MD, 20894, USA

    Arvind Chopra, Liang Shan, W. C. Eckelman, Kam Leung, Martin Latterner & Stephen H. Bryant

  2. National Cancer Institute, National Institutes of Health, Bethesda, MD, 20894, USA

    Anne Menkens

Authors
  1. Arvind Chopra
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  2. Liang Shan
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  3. W. C. Eckelman
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  4. Kam Leung
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  5. Martin Latterner
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  6. Stephen H. Bryant
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  7. Anne Menkens
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Corresponding author

Correspondence to Arvind Chopra.

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Chopra, A., Shan, L., Eckelman, W.C. et al. Molecular Imaging and Contrast Agent Database (MICAD): Evolution and Progress. Mol Imaging Biol 14, 4–13 (2012). https://doi.org/10.1007/s11307-011-0521-3

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  • DOI: https://doi.org/10.1007/s11307-011-0521-3

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