Abstract
Senescence and chronic renal failure bring about a progressive glomerular filtration reduction. Moreover, a reduction in glomerular filtration usually modifies the potassium renal excretion. In the present study, we compared the renal potassium handling between old and chronic renal disease populations. Materials and Methods: Fifty-five volunteers were studied, 43 of them were healthy old persons and 12 were predialysis chronic renal disease patients. Exclusion criteria were: presence of altered plasma potassium (Kp), diabetes mellitus, obstructive uropathy, drugs that could alter plasma potassium levels. All volunteers were on a diet with a potassium content around 50 mmol/day (3-day dietary register). We measured potassium, creatinine, urea in plasma and 24 hours urine. We also measured creatinine clearance (CrCl) and fractional excretion of potassium (FEK), and we studied the relationship between these parameters. Statistical analysis was made using Student’s test. Results: Slopes of the correlation curves between CrCl and FEK. Conclusion: The relationship between creatinine clearance and fractional excretion of potassium in old and chronic renal disease groups were different with the excretion of potassium being lower in the elderly.
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References
S Anderson T Meyer B. Brenner (1987) Mechanisms of age-associated glomerular sclerosis J Macias Nuñez S Cameron (Eds) Renal Function and Disease in the Elderly Butterworths London 49–50
A. El Nahas (1992) Mechanisms of progression and consequences of nephron reduction S Cameron A Davison JP Grünfeld D Kerr E Ritz (Eds) Oxford Textbook of Clinical Nephrology Oxford University Press Oxford 1191–1193
R. Tannen (1996) Potassium disorders J Kokko R Tannen (Eds) Fluids and Electrolytes W.B. Saunders Philadelphia 167
R Hene P Boer H Koomans et al. (1982) ArticleTitlePlasma aldosterone concentrations in chronic renal disease Kidney Int 21 98–101 Occurrence Handle7043053
R DeToro Casado F. Macias-Nuñez J (1995) ArticleTitlePhysiological Characteristics of the renal ageing : clinical consequences An. Med. Intern. 12 157–159
J Cox W. Shalaby (1981) ArticleTitlePotassium changes with age Gerontology 27 340–341 Occurrence Handle7308750
D Fliser M Zeier R Nowack E. Ritz (1993) ArticleTitleRenal functional reserve in healthy elderly subjects J Am Soc Nephrol 3 1371–1377 Occurrence Handle8439649
P. Ter Wee (1992) Initial management of chronic renal failure S Cameron A Davison JP Grünfeld D Kerr E Ritz (Eds) Oxford Textbook of Clinical Nephrology Oxford University Press Oxford 1173–1174
S Eiam-Ong S. Sabatini (2002) ArticleTitleEffect of ageing and potassium depletion on renal collecting tubule k-controlling ATPases Nephrology 7 87–91 Occurrence Handle10.1046/j.1440-1797.2002.00088.x
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Musso, C.G., Miguel, R.d., Algranati, L. et al. Renal Potassium Excretion: Comparison between Chronic Renal Disease Patients and Old People. Int Urol Nephrol 37, 167–170 (2005). https://doi.org/10.1007/s11255-004-2361-4
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DOI: https://doi.org/10.1007/s11255-004-2361-4