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A New Effective Method for the Synthesis of 1,2,4-Triazole-3-carboxamide and Ribavirin Derivatives

  • Drug Synthesis Methods and Manufacturing Technology
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Abstract

A new method for the synthesis of 1,2,4-triazole-3-carboxamide and its 5-substituted analogs has been developed. The substrate specificity of purine nucleoside phosphorylase from E. coli with respect to the synthesized bases has been studied.

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Authors and Affiliations

  1. Moscow State Academy of Fine Chemical Technology, Moscow, Russia

    M. V. Chudinov, I. D. Konstantinova, A. M. Yurkevich & V. I. Shvets

  2. Shemyakin - Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    O. I. Ryzhova, R. S. Esipov & A. I. Miroshnikov

Authors
  1. M. V. Chudinov
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  2. I. D. Konstantinova
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  3. O. I. Ryzhova
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  4. R. S. Esipov
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  5. A. M. Yurkevich
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  6. V. I. Shvets
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  7. A. I. Miroshnikov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 4, pp. 43 – 46, April, 2005.

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Chudinov, M.V., Konstantinova, I.D., Ryzhova, O.I. et al. A New Effective Method for the Synthesis of 1,2,4-Triazole-3-carboxamide and Ribavirin Derivatives. Pharm Chem J 39, 212–215 (2005). https://doi.org/10.1007/s11094-005-0119-7

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  • DOI: https://doi.org/10.1007/s11094-005-0119-7

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