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Successful Treatment of Eczema-Like Mucormycosis in a Child by Combination of Intravenous Drip and Percutaneous Injection Amphotericin B

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Abstract

We report a case of eczema-like cutaneous mucormycosis caused by Rhizopus arrhizus. A 4-year-old child was presented to our hospital with a history of gradually enlarging papule and plaque in the periumbilical area for nearly 4 years since 2 weeks after his birth, and it has been misdiagnosed as eczema for nearly 3 years. Based on histopathology examination, the fungus culture test and DNA sequencing, it was revealed that R. arrhizus should be the responsible fungus for skin infection. The patient was successfully cured by combination of intravenous drip and percutaneous injection amphotericin B for nearly 3 months, and no recrudescence was seen during a follow-up of 6-month observation.

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Acknowledgements

This study was funded by Special Program for Basic work of science and technology, funded by the Ministry of Science and Technology of China (2013FY113700), supported by National Natural Science Foundation of China (81471905) and was funded by the Chinese Academy Medical Sciences Initiative for Innovative Medicine (2016-I2M-3-021).

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Authors and Affiliations

  1. Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Mei-hua Fu, Jia Liu, Guan-zhao Liang, Gui-xia Lv & Wei-da Liu

  2. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Cheng-rang Li

  3. Department of Cosmetic Laser Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Le Wang

  4. Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Xiao-mei Zhu & Hao Chen

  5. Division of Sexually Transmitted Disease Epidemiology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Wen-long Hu

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  1. Mei-hua Fu
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  2. Jia Liu
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Correspondence to Wei-da Liu.

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Informed consent was obtained from all individual participants included in the study.

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Handling Editor: Yuping Ran.

Mei-hua Fu and Jia Liu have contributed equally to this work.

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Fu, Mh., Liu, J., Liang, Gz. et al. Successful Treatment of Eczema-Like Mucormycosis in a Child by Combination of Intravenous Drip and Percutaneous Injection Amphotericin B. Mycopathologia 184, 309–313 (2019). https://doi.org/10.1007/s11046-018-0273-6

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