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HLA-B51 gene and its expression in association with Behçet’s Disease in Denizli Province of Turkey

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Abstract

Behçet’s Disease (BD) is a multisystemic inflammatory disorder as a triad of symptoms including recurrent oral and genital aphthous ulceration, and uveitis with unknown pathogenesis. Many researchers have tried to investigate the association of HLA-B51 gene with the BD. We aimed to investigate the association of the HLA-B51 gene and its expression, also polymorphic structure by PCR, RT-PCR and sequence specific oligonucleotide primers and probes in BD patients (n: 35) and control group (n: 50). According to our results, we did not observe any association in between HLA-B51 gene, its polymorphism, expression and BD patients.

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Acknowledgements

Authors are thankful to Dr Soner Akpinar from Opthalmology Department for his valuable effort in the identification of BD patients. This study was supported by Pamukkale University Research Fund (Project No. 2001TPF020), TÜBİTAK (Scientific and Research Council of Turkey, Project No. SBAG 2388) and Turkish Government State Planning Department Project (Project No.2001K121120). DNA bank was constructed in the framework the TUBİTAK Project No.SBAG-2388.

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Authors and Affiliations

  1. Department of Biophysics, Medical Faculty, Pamukkale University, P.K. 33, 20020, Denizli, Turkey

    Ayfer Atalay, Sanem Yıldız-Demirtepe & Erol Ömer Atalay

  2. Department of Opthalmology, Medical Faculty, Pamukkale University, P.K. 33, 20020, Denizli, Turkey

    Sinan Tatlıpınar & Cem Yıldırım

  3. Department of Dermatology, Medical Faculty, Pamukkale University, P.K. 33, 20020, Denizli, Turkey

    Berna Şanlı-Erdoğan

  4. Department of Rheumatology, Medical Faculty, Pamukkale University, P.K. 33, 20020, Denizli, Turkey

    Veli Çobankara

  5. Medical Biology, Faculty of Medicine, Pamukkale University, P.K. 33, 20020, Denizli, Turkey

    Hüseyin Bağcı

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  1. Ayfer Atalay
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Correspondence to Ayfer Atalay.

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Atalay, A., Yıldız-Demirtepe, S., Tatlıpınar, S. et al. HLA-B51 gene and its expression in association with Behçet’s Disease in Denizli Province of Turkey. Mol Biol Rep 35, 345–349 (2008). https://doi.org/10.1007/s11033-007-9092-4

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  • DOI: https://doi.org/10.1007/s11033-007-9092-4

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