Abstract
Continuous research in prominent fields such as biotechnology, biomedicine and nanopharmaceutics has brought the development of a widespread class of materials, and studies for mesoporous materials have been exponentially growing lately. The purpose of this review is to provide a useful guide for different materials, methods and configurations that have been reported in the last 5 years for the synthesis of spherical mesoporous silica particles (MSP), in the colloidal size range (1–1000 nm). MSP exhibit several limitations that must be overcome in order to enable their medical and clinical use. Surface modification of these particles will allow getting new promising characteristics of these materials, including better drug release control and biocompatibility improvement. These modified MSP could be potentially used in many biomedical applications, especially for drug delivery systems. Emphasis is made on the pore size, diameter and shape of the final particles since these parameters will establish key characteristics, i.e., drug delivery profile, loading capacity and efficiency.
Graphical Abstract
Spreading the use of mesoporous silica particles in biomedicine is possible by the improvement of its inner characteristics through surface modification. This may be done by chemical functionalization or by coating with macromolecular layers or brushes, thus creating novel responsive core–shell hybrid composites to be used as carriers for drug delivery applications.
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References
Mamaeva V, Sahlgren C, Lindén M (2013) Mesoporous silica nanoparticles in medicine—recent advances. Adv Drug Deliv Rev 65:689–702
Carlsson N, Gustafsson H, Thörn C et al (2014) Enzymes immobilized in mesoporous silica: a physical—chemical perspective. Adv Colloid Interface Sci 205:339–360
Popat A, Hartono SB, Stahr F et al (2011) Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers. Nanoscale 3:2801–2818
IUPAC (2014) Compendium of Chemical Terminology—Gold Book, edition 2.3.3., 979 of 1622
Teng I-T, Chang Y-J, Wang L-S et al (2013) Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer. Biomaterials 34:7462–7470
Chen Q, Han L, Gao C, Che S (2010) Synthesis of monodispersed mesoporous silica spheres (MMSSs) with controlled particle size using gemini surfactant. Microporous Mesoporous Mater 128:203–212
Yano K, Nishi T (2012) A novel route to highly monodispersed mesoporous silica spheres consisting of nano-sized particles. Microporous Mesoporous Mater 158:257–263
Beck JS, Schmitt KD, Higgins JB, Schlenkert JL (1992) A new family of mesoporous molecular sieves prepared with liquid crystal templates. J Am Chem Soc 114:10834–10843
Zhao D, Feng J, Huo Q et al (1998) Triblock copolymer syntheses of mesoporous silica with periodic 50–300 Å pores. Science 279:548–552
Zhao D, Huo Q, Feng J et al (1998) Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures. J Am Chem Soc 120:6024–6036
Ra A, Real RP, Pe J (2001) A new property of MCM-41: drug delivery system. Chem Mater 13:308–311
Chen Y, Shi X, Han B et al (2012) The complete control for the nanosize of spherical MCM-41. J Nanosci Nanotechnol 12:7239–7249
He Y, Xu H, Ma S et al (2014) Fabrication of mesoporous spherical silica nanoparticles and effects of synthesis conditions on particle mesostructure. Mater Lett 131:361–365
Shibata H, Chiba Y, Kineri T et al (2010) The effect of heat treatment on the interplanar spacing of the mesostructure during the synthesis of mesoporous MCM-41 silica. Colloids Surfaces A Physicochem Eng Asp 358:1–5
Fuertes AB, Valle-Vigón P, Sevilla M (2010) Synthesis of colloidal silica nanoparticles of a tunable mesopore size and their application to the adsorption of biomolecules. J Colloid Interface Sci 349:173–180
Lee S, Yun H-S, Kim S-H (2011) The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis. Biomaterials 32:9434–9443
Cho E-B, Volkov DO, Sokolov I (2011) Ultrabright fluorescent silica mesoporous silica nanoparticles: control of particle size and dye loading. Adv Funct Mater 21:3129–3135
Wang T, Jiang H, Zhao Q et al (2012) Enhanced mucosal and systemic immune responses obtained by porous silica nanoparticles used as an oral vaccine adjuvant: effect of silica architecture on immunological properties. Int J Pharm 436:351–358
Tan S, Wu Q, Wang J et al (2011) Dynamic self-assembly synthesis and controlled release as drug vehicles of porous hollow silica nanoparticles. Microporous Mesoporous Mater 142:601–608
Jia L, Shen J, Li Z et al (2013) In vitro and in vivo evaluation of paclitaxel-loaded mesoporous silica nanoparticles with three pore sizes. Int J Pharm 445:12–19
Jia L, Shen J, Li Z et al (2012) Successfully tailoring the pore size of mesoporous silica nanoparticles: exploitation of delivery systems for poorly water-soluble drugs. Int J Pharm 439:81–91
He Q, Shi J, Chen F et al (2010) An anticancer drug delivery system based on surfactant-templated mesoporous silica nanoparticles. Biomaterials 31:3335–3346
Shi Y-T, Cheng H-Y, Geng Y et al (2010) The size-controllable synthesis of nanometer-sized mesoporous silica in extremely dilute surfactant solution. Mater Chem Phys 120:193–198
Ukmar T, Maver U, Planinšek O et al (2011) Understanding controlled drug release from mesoporous silicates: theory and experiment. J Control Release 155:409–417
Nandiyanto ABD, Kim S-G, Iskandar F, Okuyama K (2009) Synthesis of spherical mesoporous silica nanoparticles with nanometer-size controllable pores and outer diameters. Microporous Mesoporous Mater 120:447–453
Palantavida S, Guz NV, Woodworth CD, Sokolov I (2013) Ultrabright fluorescent mesoporous silica nanoparticles for prescreening of cervical cancer. Nanomed Nanotechnol Biol Med 9:1255–1262
Mukherjee I, Mylonakis A, Guo Y et al (2009) Effect of nonsurfactant template content on the particle size and surface area of monodisperse mesoporous silica nanospheres. Microporous Mesoporous Mater 122:168–174
Filipović R, Obrenović Z, Stijepović I et al (2009) Synthesis of mesoporous silica particles with controlled pore structure. Ceram Int 35:3347–3353
Xu W, Gao Q, Xu Y et al (2009) Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres. Powder Technol 191:13–20
Eltohamy M, Shin US, Kim H-W (2011) Silica nanoparticles with enlarged nanopore size for the loading and release of biological proteins. Mater Lett 65:3570–3573
Ruthstein S, Schmidt J, Kesselman E et al (2006) Resolving intermediate solution structures during the formation of mesoporous SBA-15. J Am Chem Soc 128:3366–3374
Wang Y, Zhang F, Wang Y et al (2009) Synthesis of length controllable mesoporous SBA-15 rods. Mater Chem Phys 115:649–655
Lee H-I, Kim J-H, Stucky G et al (2010) Morphology-selective synthesis of mesoporous SBA-15 particles over micrometer, submicrometer and nanometer scales. J Mater Chem 20:8483–8487
Johansson EM, Ballem MA (2011) Rapid synthesis of SBA-15 rods with variable lengths, widths, and tunable large pores. Langmuir 27:4994–4999
Benamor T, Vidal L, Lebeau B, Marichal C (2012) Influence of synthesis parameters on the physico-chemical characteristics of SBA-15 type ordered mesoporous silica. Microporous Mesoporous Mater 153:100–114
Guo Z, Liu X-M, Ma L et al (2013) Effects of particle morphology, pore size and surface coating of mesoporous silica on Naproxen dissolution rate enhancement. Colloids Surf B Biointerfaces 101:228–235
Mendes LS, Saska S, Martines MAU, Marchetto R (2013) Nanostructured materials based on mesoporous silica and mesoporous silica/apatite as osteogenic growth peptide carriers. Mater Sci Eng, C 33:4427–4434
Aktas O, Yasyerli S, Dogu G, Dogu T (2011) Structural variations of MCF and SBA-15-like mesoporous materials as a result of differences in synthesis solution pH. Mater Chem Phys 131:151–159
Diao X, Wang Y, Zhao J, Zhu S (2010) Effect of pore-size of mesoporous SBA-15 on adsorption of bovine serum albumin and lysozyme protein. Chinese J Chem Eng 18:493–499. doi:10.1016/S1004-9541(10)60248-0
Tadjarodi A, Zabihi F, Afshar S (2013) Experimental investigation of thermo-physical properties of platelet mesoporous SBA-15 silica particles dispersed in ethylene glycol and water mixture. Ceram Int 39:7649–7655
Mesa M, Sierra L, Guth J (2008) Contribution to the study of the formation mechanism of mesoporous SBA-15 and SBA-16 type silica particles in aqueous acid solutions. Microporous Mesoporous Mater 112:338–350
Zholobenko VL, Khodakov AY, Impéror-Clerc M et al (2008) Initial stages of SBA-15 synthesis: an overview. Adv Colloid Interface Sci 142:67–74
Yoo J-W, Doshi N, Mitragotri S (2011) Adaptive micro and nanoparticles: temporal control over carrier properties to facilitate drug delivery. Adv Drug Deliv Rev 63:1247–1256
Xing R, Lin H, Jiang P, Qu F (2012) Biofunctional mesoporous silica nanoparticles for magnetically oriented target and pH-responsive controlled release of ibuprofen. Colloids Surfaces A Physicochem Eng Asp 403:7–14
Wan H, Liu L, Li C et al (2009) Facile synthesis of mesoporous SBA-15 silica spheres and its application for high-performance liquid chromatography. J Colloid Interface Sci 337:420–426
Zhao H, Li W, Du M et al (2013) A facile strategy to synthesize spherical SBA-15 silicas by the addition of poly(vinyl alcohol). Mater Lett 92:33–35
Zhao Y, Wu D, Tang T, Sun Y (2013) One-step synthesis of hydrophobic mesoporous silica ellipsoidal particles with a bimodal mesopore system. Mater Res Bull 48:4839–4843
Cao L, Man T, Kruk M (2009) Synthesis of ultra-large-pore SBA-15 silica with two-dimensional hexagonal structure using Triisopropylbenzene as micelle expander. Chem Mater 21:1144–1153
Cao L, Kruk M (2010) Synthesis of large-pore SBA-15 silica from tetramethyl orthosilicate using triisopropylbenzene as micelle expander. Colloids Surfaces A Physicochem Eng Asp 357:91–96
Dos Santos SML, Nogueira KAB, de Souza Gama M et al (2013) Synthesis and characterization of ordered mesoporous silica (SBA-15 and SBA-16) for adsorption of biomolecules. Microporous Mesoporous Mater 180:284–292
Crommelin DJA, Florence AT (2013) Towards more effective advanced drug delivery systems. Int J Pharm 454:496–511
Sierra L, Valange S, Guth J-L (2009) Formation mechanism and morphology of mesoporous SBA-16 type silica particles prepared with the triblock copolymer surfactant PEO140PPO39PEO140. Microporous Mesoporous Mater 124:100–109
Ballem MA, Córdoba JM, Odén M (2010) Influence of synthesis temperature on morphology of SBA-16 mesoporous materials with a three-dimensional pore system. Microporous Mesoporous Mater 129:106–111
Hu Y, Wang J, Zhi Z et al (2011) Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug. J Colloid Interface Sci 363:410–417
Almeida R, Pires CT, Airoldi C (2012) The influence of secondary structure directing agents on the formation of mesoporous SBA-16 silicas. Chem Eng J 203:36–42
Andrade GF, Soares D, Almeida R, Sousa E (2012) Mesoporous silica SBA-16 functionalized with alkoxysilane groups: preparation, characterization, and release profile study. J Nanomater 2012:1–10
Andrade GF, Soares D, dos Santos R, Sousa E (2013) Mesoporous silica SBA-16 nanoparticles: synthesis, physicochemical characterization, release profile, and in vitro cytocompatibility studies. Microporous Mesoporous Mater 168:102–110
Ho S-T, Dinh Q-K, Tran T-H et al (2013) One-step synthesis of ordered Sn-substituted SBA-16 mesoporous materials using prepared silica source of rice husk and their selectively catalytic activity. Can J Chem Eng 91:34–46
Han Y, Ying JY (2004) Generalized fluorocarbon-surfactant-mediated synthesis of nanoparticles with various mesoporous structures. Angew Chem Int Ed Engl 44:288–292
Wang W, Qi R, Shan W et al (2014) Synthesis of KIT-6 type mesoporous silicas with tunable pore sizes, wall thickness and particle sizes via the partitioned cooperative self-assembly process. Microporous Mesoporous Mater 194:167–173
Xu L, Wang C, Guan J (2014) Preparation of acid-base bifunctional mesoporous KIT-6 (KIT: Korea Advanced Institute of Science and Technology) and its catalytic performance in Knoevenagel reaction. J Solid State Chem 213:250–255
Ohkubo T, Ogura T, Sakai H, Abe M (2007) Synthesis of highly-ordered mesoporous silica particles using mixed cationic and anionic surfactants as templates. J Colloid Interface Sci 312:42–46
Han L, Zhou Y, He T et al (2013) One-pot morphology-controlled synthesis of various shaped mesoporous silica nanoparticles. J Mater Sci 48:5718–5726
Lee Y-G, Oh C, Yoo S-K et al (2005) New approach for the control of size and surface characteristics of mesoporous silica particles by using mixed surfactants in W/O emulsion. Microporous Mesoporous Mater 86:134–144
Jo C, Kim K, Ryoo R (2009) Syntheses of high quality KIT-6 and SBA-15 mesoporous silicas using low-cost water glass, through rapid quenching of silicate structure in acidic solution. Microporous Mesoporous Mater 124:45–51
Martínez ML, Ponte MV, Beltramone AR, Anunziata OA (2014) Synthesis of ordered mesoporous SBA-3 materials using silica gel as silica source. Mater Lett 134:95–98
Lei C, Chen B, Li X et al (2013) Non-destructively shattered mesoporous silica for protein drug delivery. Microporous Mesoporous Mater 175:157–160
Nair R, Yoshida Y, Maekawa T, Kumar DS (2012) Size tuning and oxygen plasma induced pore formation on silica nanoparticles. Prog Nat Sci Mater Int 22:193–200
DeMuth P, Hurley M, Wu C et al (2011) Mesoscale porous silica as drug delivery vehicles: synthesis, characterization, and pH-sensitive release profiles. Microporous Mesoporous Mater 141:128–134
Nikolić MP, Giannakopoulos KP, Bokorov M, Srdić VV (2012) Effect of surface functionalization on synthesis of mesoporous silica core/shell particles. Microporous Mesoporous Mater 155:8–13
Wang L, Wu L, Lu S et al (2010) Biofunctionalized phospholipid-capped mesoporous silica nanoshuttles for targeted drug delivery: improved water suspensibility and decreased. ACS Nano 4:4371–4379
Bhattacharyya S, Wang H, Ducheyne P (2012) Polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules. Acta Biomater 8:3429–3435
Peng H, Dong R, Wang S et al (2013) A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly (acrylic acid) shell-layers: fabrication, characterization and properties for controlled release of salidroside. Int J Pharm 446:153–159
Wang G, Otuonye AN, Blair EA et al (2009) Functionalized mesoporous materials for adsorption and release of different drug molecules: a comparative study. J Solid State Chem 182:1649–1660
Sun YY-L, Wang L, Ma J et al (2014) Nanoassembles constructed from mesoporous silica nanoparticles and surface-coated multilayer polyelectrolytes for controlled drug delivery. Microporous Mesoporous Mater 185:245–253
Cauda V, Schlossbauer A, Bein T (2010) Bio-degradation study of colloidal mesoporous silica nanoparticles: effect of surface functionalization with organo-silanes and poly(ethylene glycol). Microporous Mesoporous Mater 132:60–71
Xie M, Xu Y, Shen H et al (2014) Negative-charge-functionalized mesoporous silica nanoparticles as drug vehicles targeting hepatocellular carcinoma. Int J Pharm 474:223–231
Chen X, Cheng X, Soeriyadi AH et al (2014) Stimuli-responsive functionalized mesoporous silica nanoparticles for drug release in response to various biological stimuli. Biomater Sci 2:121
Chen L, Zhang Z, Yao X et al (2015) Intracellular pH-operated mechanized mesoporous silica nanoparticles as potential drug carries. Microporous Mesoporous Mater 201:169–175
Hu X, Wang Y, Peng B (2014) Chitosan-capped mesoporous silica nanoparticles as pH-responsive nanocarriers for controlled drug release. Chem Asian J 9:319–327
Chen H, Khemtong C, Yang X et al (2011) Nanonization strategies for poorly water-soluble drugs. Drug Discov Today 16:354–360
Wu C, Zhao Z, Zhao Y et al (2014) Preparation of a push-pull osmotic pump of felodipine solubilized by mesoporous silica nanoparticles with a core-shell structure. Int J Pharm 475:298–305
He Q, Gao Y, Zhang L et al (2011) A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomaterials 32:7711–7720
Zhang Y, Zhi Z, Jiang T et al (2010) Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan. J Control Release 145:257–263
Tu J, Wang T, Shi W et al (2012) Multifunctional ZnPc-loaded mesoporous silica nanoparticles for enhancement of photodynamic therapy efficacy by endolysosomal escape. Biomaterials 33:7903–7914
He Q, Zhang J, Shi J et al (2010) The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses. Biomaterials 31:1085–1092
Guardado-Alvarez TM, Devi LS, Russell MM et al (2013) Activation of snap-top capped mesoporous silica nanocontainers using two near-infrared photons. J Am Chem Soc 135:1400–14003
Xie M, Shi H, Li Z et al (2013) A multifunctional mesoporous silica nanocomposite for targeted delivery, controlled release of doxorubicin and bioimaging. Colloids Surf B Biointerfaces 110:138–147
Li X, Reuben Q, Zhang J et al (2011) The packaging of siRNA within the mesoporous structure of silica nanoparticles. Biomaterials 32:9546–9556
Vivero-Escoto JL, Slowing II, Lin VS-Y (2010) Tuning the cellular uptake and cytotoxicity properties of oligonucleotide intercalator-functionalized mesoporous silica nanoparticles with human cervical cancer cells HeLa. Biomaterials 31:1325–1333
Popova MD, Szegedi Á, Kolev IN et al (2012) Carboxylic modified spherical mesoporous silicas a s drug delivery carriers. Int J Pharm 436:778–785
Wang J, Shen Y, Bai L et al (2014) Mesoporous silica shell alleviates cytotoxicity and inflammation induced by colloidal silica particles. Colloids Surf B Biointerfaces 116:334–342
Hao N, Li LL, Zhang Q et al (2012) The shape effect of PEGylated mesoporous silica nanoparticles on cellular uptake pathway in Hela cells. Microporous Mesoporous Mater 162:14–23
Zhao Y, Li Z, Kabehie S et al (2010) pH-Operated nanopistons on the surfaces of mesoporous silica nanoparticles. J Am Chem Soc 132:13016–13025
Lu J, Li Z, Zink JI, Tamanoi F (2012) In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification. Nanomed Nanotechnol Biol Med 8:212–220
Tarn D, Xue M, Zink JI (2013) pH-Responsive dual cargo delivery from mesoporous silica nanoparticles with a metal-latched nanogate. Inorg Chem 52:2044–2049
Jambhrunkar S, Qu Z, Popat A et al (2014) Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles. J Colloid Interface Sci 434:218–225
Yoncheva K, Popova M, Szegedi A et al (2014) Functionalized mesoporous silica nanoparticles for oral delivery of budesonide. J Solid State Chem 211:154–161
Szegedi A, Popova M, Goshev I et al (2012) Controlled drug release on amine functionalized spherical MCM-41. J Solid State Chem 194:257–263
Choi E, Lu J, Tamanoi F, Zink JI (2014) Drug release from three-dimensional cubic mesoporous silica nanoparticles controlled by nanoimpellers. Zeitschrift für Anorg und Allg Chemie 640:588–594
Chen C, Pu F, Huang Z et al (2011) Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers. Nucleic Acids Res 39:1638–1644
Gary-Bobo M, Brevet D, Benkirane-Jessel N et al (2012) Hyaluronic acid-functionalized mesoporous silica nanoparticles for efficient photodynamic therapy of cancer cells. Photodiagnosis Photodyn Ther 9:256–260
Gary-Bobo M, Hocine O, Brevet D et al (2012) Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT. Int J Pharm 423:509–515
Gary-Bobo M, Mir Y, Rouxel C et al (2011) Mannose-functionalized mesoporous silica nanoparticles for efficient two-photon photodynamic therapy of solid tumors. Angew Chem Int Ed Engl 50:11425–11429
Pan L, Liu J, He Q et al (2013) Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles. Biomaterials 34:2719–2730
Hu L, Sun C, Song A et al (2014) Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin. Asian J Pharm Sci 9:183–190
Brevet D, Hocine O, Delalande A et al (2014) Improved gene transfer with histidine-functionalized mesoporous silica nanoparticles. Int J Pharm 471:197–205
Qu Y, Feng L, Liu B et al (2014) Colloids and surfaces a: physicochemical and engineering aspects a facile strategy for synthesis of nearly white light emitting mesoporous silica nanoparticles. Colloids Surfaces A Physicochem Eng Asp 441:565–571
Tsai C-H, Vivero-Escoto JL, Slowing II et al (2011) Surfactant-assisted controlled release of hydrophobic drugs using anionic surfactant templated mesoporous silica nanoparticles. Biomaterials 32:6234–6244
Morelli C, Maris P, Sisci D et al (2011) PEG-templated mesoporous silica nanoparticles exclusively target cancer cells. Nanoscale 3:3198–3207
Ma L, Nikzad S, Kheiri-Manjili H (2014) Curcumin-loaded guanidine functionalized PEGylated I3ad mesoporous silica nanoparticles KIT-6: practical strategy for the breast cancer therapy. Eur J Med Chem 83:646–654
Li X, Hong C, Pan C (2010) Preparation and characterization of hyperbranched polymer grafted mesoporous silica nanoparticles via self-condensing atom transfer radical vinyl polymerization. Polymer (Guildf) 51:92–99
Wu S, Li Z, Han J, Han S (2011) Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity w. Chem Commun 47:11276–11278
Kim MS, Jeon JB, Chang JY (2013) Microporous and mesoporous materials selectively functionalized mesoporous silica particles with the PEGylated outer surface and the doxorubicin-grafted inner surface: improvement of loading content and solubility. Microporous Mesoporous Mater 172:118–124
Zheng J, Tian X, Sun Y et al (2013) pH-sensitive poly (glutamic acid) grafted mesoporous silica nanoparticles for drug delivery. Int J Pharm 450:296–303
Wang J, Liu H, Leng F et al (2014) Autofluorescent and pH-responsive mesoporous silica for cancer-targeted and controlled drug release. Microporous Mesoporous Mater 186:187–193
Zhang X, Li F, Guo S et al (2014) Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells. Biomaterials 35:3650–3665
Zheng Q, Lin T, Wu H et al (2014) Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release. Int J Pharm 463:22–26
Li H, Zhang JZ, Tang Q et al (2013) Reduction-responsive drug delivery based on mesoporous silica nanoparticle core with crosslinked poly(acrylic acid) shell. Mater Sci Eng C Mater Biol Appl 33:3426–3431
Zhang B, Luo Z, Liu J et al (2014) Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo. J Control Release 192:192–201
Zhang Q, Ye Z, Wang S-T, Yin J (2014) Facile one-pot synthesis of PEGylated monodisperse mesoporous silica nanoparticles with controllable particle sizes. Chinese Chem Lett 25:257–260
Li G, Cheng G, Xue H et al (2008) Ultra low fouling zwitterionic polymers with a biomimetic adhesive group. Biomaterials 29:4592–4597
Carr LR, Xue H, Jiang S (2011) Functionalizable and nonfouling zwitterionic carboxybetaine hydrogels with a carboxybetaine dimethacrylate crosslinker. Biomaterials 32:961–968
Suzuki H, Murou M, Kitano H et al (2011) Silica particles coated with zwitterionic polymer brush: formation of colloidal crystals and anti-biofouling properties in aqueous medium. Colloids Surf B Biointerfaces 84:111–116
Wang M, Yuan J, Huang X et al (2013) Grafting of carboxybetaine brush onto cellulose membranes via surface-initiated ARGET-ATRP for improving blood compatibility. Colloids Surf B Biointerfaces 103:52–58
Colilla M, Izquierdo-Barba I, Sánchez-Salcedo S et al (2010) Synthesis and characterization of zwitterionic SBA-15 nanostructured materials. Chem Mater 22:6459–6466
Pop-Georgievski O, Rodriguez-Emmenegger C, Pereira A et al (2013) Biomimetic non-fouling surfaces: extending the concepts. J Mater Chem B 1:2859
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Beltrán-Osuna, Á.A., Perilla, J.E. Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications. J Sol-Gel Sci Technol 77, 480–496 (2016). https://doi.org/10.1007/s10971-015-3874-2
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DOI: https://doi.org/10.1007/s10971-015-3874-2