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Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination

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Abstract

The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate that FOXO3 is implicated in the control of mitochondrial function beyond regulating levels of ROS in HSC. Here we review these findings and discuss implications for homeostatic blood formation and stem cell fate determination.

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Acknowledgments

R.L. is supported by an American Heart Association fellowship and S.G. by NIH CA205975, HL116365 and HL136255.

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Authors and Affiliations

  1. Department of Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Raymond Liang & Saghi Ghaffari

  2. Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Raymond Liang & Saghi Ghaffari

  3. Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Saghi Ghaffari

  4. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Saghi Ghaffari

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  1. Raymond Liang
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  2. Saghi Ghaffari
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Correspondence to Saghi Ghaffari.

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Liang, R., Ghaffari, S. Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination. J Bioenerg Biomembr 49, 343–346 (2017). https://doi.org/10.1007/s10863-017-9719-7

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  • DOI: https://doi.org/10.1007/s10863-017-9719-7

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