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Systematic review of economic burden of heart failure

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Abstract

The aim of this study is to perform a systematic review of the costing methodological approaches adopted by published cost-of-illness (COI) studies. A systematic review was performed to identify cost-of-illness studies of heart failure published between January 2003 and September 2015 via computerized databases such as Pubmed, Wiley Online, Science Direct, Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). Costs reported in the original studies were converted to 2014 international dollars (Int$). Thirty five out of 4972 studies met the inclusion criteria. Nineteen out of the 35 studies reported the costs as annual cost per patient, ranging from Int$ 908.00 to Int$ 84,434.00, while nine studies reported costs as per hospitalization, ranging from Int$ 3780.00 to Int$ 34,233.00. Cost of heart failure increased as condition of heart failure worsened from New York Heart Association (NYHA) class I to NYHA class IV. Hospitalization cost was found to be the main cost driver to the total health care cost. The annual cost of heart failure ranges from Int$ 908 to Int$ 40,971 per patient. The reported cost estimates were inconsistent across the COI studies, mainly due to the variation in term of methodological approaches such as disease definition, epidemiological approach of study, study perspective, cost disaggregation, estimation of resource utilization, valuation of unit cost components, and data sources used. Such variation will affect the reliability, consistency, validity, and relevance of the cost estimates across studies.

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Acknowledgements

All authors were involved in the conception and design of this work and approved the final manuscript. The preparation of this review did not receive any external funding or a grant. Y.P. Tan and C.H. Ng were the independent reviewers of the literature and were also responsible for study abstraction. Y.P. Tan and A.A. Shafie wrote the manuscript. A.A. Shafie supervised all systematic review activities and was responsible for the final manuscript review. A.A. Shafie is the overall guarantor for this article.

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Authors and Affiliations

  1. Discipline of Social Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia

    Asrul Akmal Shafie, Yui Ping Tan & Chin Hui Ng

Authors
  1. Asrul Akmal Shafie
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  2. Yui Ping Tan
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  3. Chin Hui Ng
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Correspondence to Asrul Akmal Shafie.

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This article did not contain any studies with human participants performed by any of the authors.

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Informed consent was not needed as there was no human participant involved in this study.

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Key Points for Decision Makers

• The wide variation in cost estimates across different cost of illness studies of heart failure needs careful analysis and interpretation.

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Shafie, A.A., Tan, Y.P. & Ng, C.H. Systematic review of economic burden of heart failure. Heart Fail Rev 23, 131–145 (2018). https://doi.org/10.1007/s10741-017-9661-0

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  • DOI: https://doi.org/10.1007/s10741-017-9661-0

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