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CDH1 germline mutations and hereditary lobular breast cancer

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Abstract

Hereditary diffuse gastric cancer is an autosomal dominant inherited disease associated of CDH1 germline mutations (that encodes for the E-cadherin protein), and lobular breast cancer is the second most frequent type of neoplasia. Recently, novel E-cadherin constitutional alterations have been identified in pedigree clustering only for lobular breast carcinoma without evidence of diffuse gastric tumors and in absence of BRCA1/2 mutations. This first evidence opens novel questions about the inherited correlation between diffuse gastric and lobular breast cancers. In this brief review we revise the literature data about the CDH1 mutation frequency affecting exclusively lobular breast cancer, providing clinical recommendation for asymptomatic mutation carriers.

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Acknowledgments

This manuscript was support by AIRC 5 × 1000 grant.

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Authors and Affiliations

  1. Division of Senology, European Institute of Oncology, via G, Ripamonti 435, 20141, Milan, Italy

    Giovanni Corso, Mattia Intra, Paolo Veronesi & Viviana Galimberti

  2. Division of Breast Imaging, European Institute of Oncology, via G, Ripamonti 435, 20141, Milan, Italy

    Chiara Trentin

Authors
  1. Giovanni Corso
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  2. Mattia Intra
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  3. Chiara Trentin
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  4. Paolo Veronesi
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  5. Viviana Galimberti
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Correspondence to Giovanni Corso.

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Corso, G., Intra, M., Trentin, C. et al. CDH1 germline mutations and hereditary lobular breast cancer. Familial Cancer 15, 215–219 (2016). https://doi.org/10.1007/s10689-016-9869-5

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  • DOI: https://doi.org/10.1007/s10689-016-9869-5

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