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Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis

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Abstract

Background

Obesity is recently known as a risk factor for endoscopic gastritis. Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear.

Aims

The aim of this study was to determine whether lower serum adiponectin level is associated with the risk of endoscopic gastritis.

Methods

We analyzed medical records of participants of a routine health check-up examination. Association among endoscopic findings, serum adiponectin level, and other clinical factors including age, sex, alcohol habit, smoking habit, body mass index (BMI), blood pressure, cholesterol, triglyceride, glucose, and insulin were investigated. Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus’ suckers.

Results

A total of 2,400 participants were enrolled. BMI was significantly higher in gastritis-positive participants than in gastritis-negative participants. Serum adiponectin levels were significantly lower in gastritis-positive participants than in gastritis-negative participants. Multivariate logistic regression analysis revealed that lower serum adiponectin level (OR 0.96; 95% CI 0.93–0.99), smoking (OR 0.50; 95% CI 0.30–0.80), higher blood pressure (OR 1.02; 95% CI 1.01–1.03), and duodenitis (OR 1.8; 95% CI 1.00–3.09) were significantly associated with endoscopic erosive gastritis.

Conclusions

Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis.

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Acknowledgments

The authors thank Shoji Ishitani at Sumitomo Hospital for the assiduous effort in data collection from the annual health checkup records.

Conflict of interest

The authors declare no conflict of interest and no grant support or other financial arrangement with any of the commercial entities mentioned in this report.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Shunsuke Yamamoto, Kenji Watabe, Shusaku Tsutsui, Shinichi Kiso, Motohiko Kato, Yoshihiro Kamada & Yuichi Yoshida

  2. Department of Biomedical Statistics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Toshimitsu Hamasaki

  3. Department of Biomedical Informatics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Shinji Kihara

  4. Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan

    Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto & Yuji Matsuzawa

  5. Kansai Rosai Hospital, 3-1-69 Inabashou, Amagasaki, Hyogo, 660-8511, Japan

    Norio Hayashi

Authors
  1. Shunsuke Yamamoto
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  2. Kenji Watabe
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  3. Shusaku Tsutsui
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  4. Shinichi Kiso
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  16. Yoshifumi Tsukamoto
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  18. Yuji Matsuzawa
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Corresponding author

Correspondence to Kenji Watabe.

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Yamamoto, S., Watabe, K., Tsutsui, S. et al. Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis. Dig Dis Sci 56, 2354–2360 (2011). https://doi.org/10.1007/s10620-011-1681-3

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  • DOI: https://doi.org/10.1007/s10620-011-1681-3

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