Skip to main content
SpringerLink
Log in

Fecal Calprotectin Levels in Patients with Colonic Polyposis

  • Original Paper
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Context

The usefulness of stool calprotectin determination in diagnosis of inflammatory disease of the colon has been reported; information about its usefulness for patients with polyposis are scarce, however.

Objective

To evaluate the significance of stool calprotectin concentrations for patients affected by colonic polyposis.

Patients

Sixty-three consecutive patients (35 males, 28 females, mean age 60.3 years, range 39–78 years) were enrolled: 26 patients (41.3%) with polyps, 17 patients (27.0%) with asymptomatic diverticular disease, and 20 subjects (31.7%) with normal endoscopic appearance of the colon.

Results

Stool calprotectin concentrations were 17.4 ± 24.5 μg g−1 for patients with colonic polyposis, significantly higher than concentrations for patients with diverticulosis (7.1 ± 5.7 μg g−1; P = 0.026) or for patients with normal appearance of the colon (calprotectin 6.0 ± 5.8 μg g−1; P = 0.003). For patients with a single polyp, stool calprotectin concentrations were similar to those for patients with multiple polyps. Calprotectin fecal concentrations for patients with sessile polyps and those with flat polyps were not significantly different. Calprotectin concentrations were not significantly related to the size of the polyps.

Conclusion

Our data show that colonic polyposis may cause an increase in stool calprotectin values and that these colonic lesions should be suspected when elevated stool calprotectin concentrations are found.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Johns LE, Houlston RS (2001) A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 96:2992–3003

    Article  PubMed  CAS  Google Scholar 

  2. Jorgensen OD, Kronborg O, Fenger C (1993) The funen adenoma follow-up study. Incidence and death from colorectal carcinoma in an adenoma surveillance program. Scan J Gastroenterol 28:869–874

    Article  CAS  Google Scholar 

  3. Rex DK, Johnson DA, Lieberman DA (2000) Colorectal cancer prevention: screening recommendations of the American College of Gastroenterology. Am J Gastroenterol 95:868–877

    PubMed  CAS  Google Scholar 

  4. O’Hare A, Fenlon H (2006) Virtual colonoscopy in the detection of colonic polyps and neoplasms. Best Pract Res Clin Gastroenterol 20:79–92

    Article  PubMed  Google Scholar 

  5. Ahmed FE (2003) Colon cancer: prevalence, screening, gene expression and mutation, and risk factors and assessment. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 21:65–131

    PubMed  Google Scholar 

  6. Gutfeld O, Prus D, Ackerman Z, Dishon S, Linke RP, Levin M, Urieli-Shoval S (2006) Expression of serum amyloid A, in normal, dysplastic, and neoplastic human colonic mucosa: implication for a role in colonic tumorigenesis. J Histochem Cytochem 54:63–73

    Article  PubMed  CAS  Google Scholar 

  7. Voganatsi A, Panyutich A, Miyasaki KT, Murthy RK (2001) Mechanism of extracellular release of human neutrophil calprotectin complex. J Leukoc Biol 70:130–134

    PubMed  CAS  Google Scholar 

  8. Roseth AG, Fagerhol MK, Aadland E, Schjonsby H (1992) Assessment of the neutrophil dominating protein calprotectin in feces. A methodologic study. Scand J Gastroenterol 27:793–798

    Article  PubMed  CAS  Google Scholar 

  9. D’Inca R, Dal Pont E, Di Leo V, Ferronato A, Fries W, Vettorato MG, Martines D, Sturniolo GC (2006) Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease. Int J Colorectal Dis epub ahead of print

  10. Orlando A, Modesto I, Castiglione F, Scala L, Scimeca D, Rispo A, Teresi S, Mocciaro F, Criscuoli V, Marrone C, Platania P, De Falco T, Maisano S, Nicoli N, Cottone M (2006) The role of calprotectin in predicting endoscopic post-surgical recurrence in asymptomatic Crohn’s disease: a comparison with ultrasound. Eur Rev Med Pharmacol Sci 10:17–22

    PubMed  CAS  Google Scholar 

  11. Vermeire S, Van Assche G, Rutgeerts P (2006) Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut 55:426–431

    Article  PubMed  CAS  Google Scholar 

  12. Bremner A, Roked S, Robinson R, Phillips I, Beattie M (2005) Faecal calprotectin in children with chronic gastrointestinal symptoms. Acta Paediatr 94:1855–1858

    Article  PubMed  Google Scholar 

  13. Vieten D, Cairns P (2005) The role of calprotectin in the diagnosis of neonatal necrotising enterocolitis. Ir Med J 98:69

    PubMed  CAS  Google Scholar 

  14. Roseth AG (2003) Determination of faecal calprotectin, a novel marker of organic gastrointestinal disorders. Dig Liver Dis 35:607–609

    Article  PubMed  CAS  Google Scholar 

  15. Tibble JA, Sigthorsson G, Foster R, Scott D, Fagerhol MK, Roseth A, Bjarnason I (1999) High prevalence of NSAID enteropathy as shown by a simple faecal test. Gut 45:362–6

    Article  PubMed  CAS  Google Scholar 

  16. Homann C, Christensen E, Schlichting P, Philipsen EK, Graudal NA, Garred P (2003) Ascites fluid and plasma calprotectin concentrations in liver disease. Scand J Gastroenterol 38:415–420

    Article  PubMed  CAS  Google Scholar 

  17. Ton H, Brandsnes, Dale S, Holtlund J, Skuibina E, Schjonsby H, Johne B (2000) Improved assay for fecal calprotectin. Clin Chim Acta 292:41–54

    Article  PubMed  CAS  Google Scholar 

  18. Saverymuttu SH, Maltby P, Batman P, Joseph AE, Maxwell D (1986) False positive localisation of indium-111 granulocytes in colonic carcinoma. Br J Radiol 59:773–777

    Article  PubMed  CAS  Google Scholar 

  19. Tibble J, Sigthorsson G, Foster R, Sherwood R, Fagerhol M, Bjarnason I (2001) Faecal calprotectin and faecal occult blood tests in the diagnosis of colorectal carcinoma and adenoma. Gut 49:402–408

    Article  PubMed  CAS  Google Scholar 

  20. Hoff G, Grotmol T, Thiis-Evensen E, Bretthauer M, Gondal G, Vatn MH (2004) Testing for faecal calprotectin (PhiCal) in the Norwegian Colorectal Cancer Prevention trial on flexible sigmoidoscopy screening: comparison with an immunochemical test for occult blood (FlexSure OBT). Gut 53:1329–1331

    Article  PubMed  CAS  Google Scholar 

  21. Kang JY, Dhar A, Pollok R, Leicester RJ, Benson MJ, Kumar D, Melville D, Neild PJ, Tibbs CJ, Maxwell JD (2004) Diverticular disease of the colon: ethnic differences in frequency. Aliment Pharmacol Ther 19:765–769

    Article  PubMed  CAS  Google Scholar 

  22. Souques M, Lassalle M, Guldner L, Asselain B, Barres D, Pavis C, Dubois G, Martin E, Flejou JF (2006) Colorectal polyps and cancers diagnosed by pathologists in Ile de France Region Crisapif-Petri Study. Gastroenterol Clin Biol 30:587–593

    Article  PubMed  Google Scholar 

  23. Dobbins C, Defontgalland D, Duthie G, Wattchow DA (2006) The relationship of obesity to the complications of diverticular disease. Colorectal Dis 8:37–40

    Article  PubMed  CAS  Google Scholar 

  24. Betes M, Munoz-Navas MA, Duque JM, Angos R, Macias E, Subtil JC, Herraiz M, De La Riva S, Delgado-Rodriguez M, Martinez-Gonzalez MA (2003) Use of colonoscopy as a primary screening test for colorectal cancer in average risk people. Am J Gastroenterol 98:2648–2654

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Gastroenterology, Sant’Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, Bologna, 40138, Italy

    Raffaele Pezzilli, Antonio M. Morselli Labate, Lorenzo Fantini, Giuseppe Gizzi, Valeria Villani & Roberto Corinaldesi

  2. Department of Medicine, Surgery and Dentistry, University of Milan, Milan, Italy

    Alessandra Barassi & Gianvico Melzi d’Eril

  3. Central Laboratory, Legnano Hospital, Legnano, Italy

    Sergio Finazzi & Milvia Lotzniker

Authors
  1. Raffaele Pezzilli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alessandra Barassi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antonio M. Morselli Labate
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sergio Finazzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lorenzo Fantini
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Giuseppe Gizzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Milvia Lotzniker
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Valeria Villani
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Gianvico Melzi d’Eril
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Roberto Corinaldesi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Raffaele Pezzilli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pezzilli, R., Barassi, A., Morselli Labate, A.M. et al. Fecal Calprotectin Levels in Patients with Colonic Polyposis. Dig Dis Sci 53, 47–51 (2008). https://doi.org/10.1007/s10620-007-9820-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-007-9820-6

Keywords

Search

Navigation