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Lipoxygenase Pathway of Arachidonic Acid Metabolism in Growth Control of Tumor Cells of Different Type

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Abstract

The influence of inhibitors of different lipoxygenases (LOX) on the growth of human tumor cells with different profiles of synthesized eicosanoids was studied. The studied LOX inhibitors had virtually no influence on the growth of A549 cells actively synthesizing cyclooxygenase and lipoxygenase metabolites of arachidonic acid (AA). The inhibitor of 12-LOX, baicalein, significantly inhibited proliferation in cultures of A431 epidermoid carcinoma cells with a characteristic domination of the major lipoxygenase metabolite of AA, 12-hydroxyeicosatetraenoic acid (12-HETE), in the profile of synthesized eicosanoids and reduced to 70% the incorporation of [3H]thymidine into DNA. Treatment of these cultures with 12-HETE virtually restored the growth potential of the tumor cells. The findings suggest that the lipoxygenase metabolite of AA, 12-HETE, is a growth-limiting factor for tumor cells of definite type.

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REFERENCES

  1. Myasishcheva, N. V., and Kudryavtsev, I. A. (2004) Carcinogenesis (Zaridze, D. G., ed.) [in Russian], Nauka, Moscow, pp. 517–522.

    Google Scholar 

  2. Tsuji, S., Tsujii, M., and Hori, M. (2001) J. Exp. Clin. Cancer Res., 20, 117–129.

    PubMed  CAS  Google Scholar 

  3. Dempke, W., Rie, C., Grothey, A., and Schmoll, H. J. (2001) J. Cancer Res. Clin. Oncol., 127, 411–417.

    Article  PubMed  CAS  Google Scholar 

  4. Prasad, K. N. (1982) Prostaglandins and Cancer: First Int. Conf., Alan R. Liss, New York, pp. 437–451.

    Google Scholar 

  5. Santoro, M. G., Crisari, A., Benedetto, A., and Amici, A. (1986) Cancer Res., 46, 6073–6077.

    PubMed  CAS  Google Scholar 

  6. Kikuchi, Y., Miyauchi, M., Oomori, K., Kita, T., Kizawa, I., and Kato, K. (1986) Cancer Res., 46, 3364–3366.

    PubMed  CAS  Google Scholar 

  7. Chinery, R., Beauchamp, R. D., Shyr, Y., Kirkland, S. C., Coffey, R. J., and Morrow, J. D. (1998) Cancer Res., 58, 2323–2327.

    PubMed  CAS  Google Scholar 

  8. Shiff, S. J., Koustsos, M. I., Qiao, I., and Rigas, B. (1996) Exp. Cell Res., 222, 179–188.

    Article  PubMed  CAS  Google Scholar 

  9. Kudryavtsev, I. A., and Myasishcheva, N. V. (1995) Vestn. Ros. Akad. Med. Nauk, 4, 42–45.

    Google Scholar 

  10. Kudryavtsev, I. A., Taranenko, I. P., Alekseev, S. M., Evstigneeva, R. P., and Khristoforov, V. L. (1991) Eksp. Onkol., 13, 61–65.

    CAS  Google Scholar 

  11. Kudryavtsev, I. A., Golenko, O. D., Gudkova, M. V., and Myasishcheva, N. V. (2002) Biochemistry (Moscow), 67, 1021–1026.

    Article  CAS  Google Scholar 

  12. Tang, S., Bhatia, B., Maldonado, C. J., Yang, P., Newman, R. A., Liu, J., Chandra, D., Traag, J., Klein, R. D., Fischer, S. M., Chopra, D., Shen, J., Zhau, H. E., Chung, L. W., and Tang, D. G. (2002) J. Biol. Chem., 277, 16189–16201.

    PubMed  CAS  Google Scholar 

  13. Fine, R. L., Jett, M., Ahn, C. H., Iglehart, D., Williams, A., and Albers, M. (1991) Proc. Annu. Meet. Am. Assoc. Cancer Res., 32, A293.

    Google Scholar 

  14. Ghosh, J., and Myers, C. E. (1997) Biochem. Biophys. Res. Commun., 235, 418–423.

    Article  PubMed  CAS  Google Scholar 

  15. Ghosh, J., and Myers, C. E. (1998) Proc. Natl. Acad. Sci. USA, 95, 13182–13187.

    Article  PubMed  CAS  Google Scholar 

  16. Tong, W. G., Ding, X. Z., and Adrian, T. E. (2002) Biochem. Biophys. Res. Commun., 296, 942–948.

    Article  PubMed  CAS  Google Scholar 

  17. Ding, X. Z., Iversen, P., Cluck, M. W., Knezetic, J. A., and Adrian, T. E. (1999) Biochem. Biophys. Res. Commun., 261, 218–223.

    Article  PubMed  CAS  Google Scholar 

  18. Chen, C.-J., Huang, H.-S., Lee, Y.-T., Yang, C. Y., and Chang, W. C. (1997) Biochem. J., 327, 193–198.

    PubMed  CAS  Google Scholar 

  19. Chang, W. C., Ning, C. C., Lin, M. T., and Huang, J. D. (1992) J. Biol. Chem., 267, 3657–3666.

    PubMed  CAS  Google Scholar 

  20. Honn, K. V., Tang, D. G., Gao, X., Butovich, I. A., Liu, B., Timar, J., and Hagmann, W. (1994) Cancer Metastasis Rev., 13, 365–396.

    Article  PubMed  CAS  Google Scholar 

  21. Hong, S. H., Avis, I., Vos, M. D., Yang, C. Y., and Chang, W. C. (1999) Cancer Res., 59, 2223–2228.

    PubMed  CAS  Google Scholar 

  22. Myasishcheva, N. V., Golenko, O. D., Kudryavtsev, I. A., Gudkova, M. V., Oreshkin, A. E., and Batrak, E. E. (1999) Eksp. Onkol., 21, 255–259.

    CAS  Google Scholar 

  23. Ogmundsdottir, H. M., Mar Zoega, G., Gissurarson, S. R., and Ingolfsdottir, K. (1998) J. Pharm. Pharmacol., 50, 107–115.

    PubMed  CAS  Google Scholar 

  24. Kort, W. J., Zijlstra, F. J., and Weijma, I. M. (1989) Prostagland. Leukotr. Ess. Fatty Acids, 37, 113–120.

    CAS  Google Scholar 

  25. Glantschnig, H., Varga, F., and Klaushofer, K. (1996) Endocrinology, 137, 4536–4541.

    PubMed  CAS  Google Scholar 

  26. Chen, Y., and Hughes-Fulford, M. (2000) Br. J. Cancer, 82, 2000–2006.

    PubMed  CAS  Google Scholar 

  27. Yakar, I., Melamed, R., Shakhar, G., Shakhar, K., Rosenne, E., Abudarham, N., Page, G. G., and Ben-Eliyahu, S. (2003) Ann. Surg. Oncol., 10, 469–479.

    Article  PubMed  Google Scholar 

  28. Olaso, E., Salado, C., Egilegor, E., Gutierrez, V., Santisteban, A., Sancho-Bru, P., Friedman, S. L., and Vidal-Vanaclocha, F. (2003) Hepatology, 37, 674–685.

    Article  PubMed  CAS  Google Scholar 

  29. Davel, L. E., Rimmaudo, L., Espanol, A., de la Torre, E., Jasnis, M. A., Ribeiro, M. L., Gotoh, T., de Lustig, E. S., and Sales, M. E. (2004) Angiogenesis, 7, 45–51.

    Article  PubMed  CAS  Google Scholar 

  30. Evans, D. M., and Sloan Stakleff, K. D. (2004) Clin. Exp. Metastasis, 21, 339–346.

    Article  PubMed  CAS  Google Scholar 

  31. Fosslien, E. (2000) Ann. Clin. Lab. Sci., 30, 3–21.

    PubMed  CAS  Google Scholar 

  32. Nugent, K. P., Spigelman, A. D., and Philips, R. K. S. (1996) Dis. Colon Rectum, 39, 659–662.

    Article  PubMed  CAS  Google Scholar 

  33. Boolbol, S. K., Dannenberg, A. J., Chadburg, A., Martucci, C., Guo, X.-J., Ramonetti, J. T., Abreu-Goris, M., Newmark, H. L., Lipkin, M. L., DeCosse, J. J., and Bertagnolli, M. M. (1996) Cancer Res., 56, 2556–2560.

    PubMed  CAS  Google Scholar 

  34. Fischer, S. M., and Slaga, T. J. (1982) Prostaglandins and Cancer: First Int. Conf., Alan R. Liss, New York, pp. 255–264.

    Google Scholar 

  35. Bespalov, V. G., Lidak, M. Yu., Petrov, A. S., Troyan, D. N., and Aleksandrov, V. A. (1992) Eksp. Onkol., 14, 36–40.

    CAS  Google Scholar 

  36. Hofer, D., Dubitsky, A. M., Reilly, P., Santoro M. G., and Jaffe, B. M. (1980) Prostaglandins, 20, 1033–1038.

    Article  PubMed  CAS  Google Scholar 

  37. Feldman, J. M., and Hilf, R. (1985) J. Natl. Cancer Inst., 75, 751–756.

    PubMed  CAS  Google Scholar 

  38. Huang, N. N., Ahmed, A. H., Wang, D. J., and Heppel, L. A. (1992) Biochem. Biophys. Res. Commun., 182, 836–843.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Carcinogenesis, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, 115478, Moscow, Russia

    I. A. Kudryavtsev, M. V. Gudkova, O. M. Pavlova, A. E. Oreshkin & N. V. Myasishcheva

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  1. I. A. Kudryavtsev
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  2. M. V. Gudkova
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  3. O. M. Pavlova
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  4. A. E. Oreshkin
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  5. N. V. Myasishcheva
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Correspondence to I. A. Kudryavtsev.

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__________

Translated from Biokhimiya, Vol. 70, No. 12, 2005, pp. 1696–1704.

Original Russian Text Copyright © 2005 by Kudryavtsev, Gudkova, Pavlova, Oreshkin, Myasishcheva.

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Kudryavtsev, I.A., Gudkova, M.V., Pavlova, O.M. et al. Lipoxygenase Pathway of Arachidonic Acid Metabolism in Growth Control of Tumor Cells of Different Type. Biochemistry (Moscow) 70, 1396–1403 (2005). https://doi.org/10.1007/s10541-005-0275-0

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  • DOI: https://doi.org/10.1007/s10541-005-0275-0

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