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Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity

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Abstract

Semax (100 µM) and its Pro-Gly-Pro fragment (20 and 100 µM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity. Incubation with these peptides improved neuronal survival by on average 30%. The neuroprotective effect of semax in cerebral ischemia/hypoxia can be due to improvement of mitochondrial resistance to “calcium” stress.

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Authors and Affiliations

  1. Laboratory of Membranology, Center of Children’s Health, Russian Academy of Medical Sciences, Russia

    T. P. Storozhevykh, G. R. Tukhbatova, Ya. E. Senilova & V. G. Pinelis

  2. Department of Chemistry of Physiologically Active Substances, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow

    L. A. Andreeva & N. F. Myasoyedov

Authors
  1. T. P. Storozhevykh
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  2. G. R. Tukhbatova
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  3. Ya. E. Senilova
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  4. V. G. Pinelis
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  5. L. A. Andreeva
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  6. N. F. Myasoyedov
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Correspondence to T. P. Storozhevykh.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 5, pp. 538–541, May, 2007

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Storozhevykh, T.P., Tukhbatova, G.R., Senilova, Y.E. et al. Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity. Bull Exp Biol Med 143, 601–604 (2007). https://doi.org/10.1007/s10517-007-0192-x

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  • DOI: https://doi.org/10.1007/s10517-007-0192-x

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