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Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cell during the development doxorubicin resistance

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cells K562, MCF-7, and SKOV-3 was studied during the development of resistance to doxorubicin. It was found that the development of resistance was accompanied by predominant increase in the expression of hGSTP1 gene in MCF-7 cells, and hGSTA4 gene in resistant K562/DOX and SKVLB cells.

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Authors and Affiliations

  1. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Russia

    E. V. Kalinina, A. N. Saprin, Ya. N. Kotova, V. I. Remizov & N. P. Shcherbak

  2. Russian People’s Friendship University, Moscow

    N. N. Chernov

Authors
  1. E. V. Kalinina
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  2. N. N. Chernov
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  3. A. N. Saprin
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  4. Ya. N. Kotova
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  5. V. I. Remizov
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  6. N. P. Shcherbak
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Corresponding author

Correspondence to E. V. Kalinina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 3, pp. 298–301, March, 2007

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Kalinina, E.V., Chernov, N.N., Saprin, A.N. et al. Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cell during the development doxorubicin resistance. Bull Exp Biol Med 143, 328–330 (2007). https://doi.org/10.1007/s10517-007-0102-2

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  • DOI: https://doi.org/10.1007/s10517-007-0102-2

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