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Effects of delta sleep-inducing peptide on pre-and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats

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Abstract

We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats. It was shown that delta sleep-inducing peptide considerably and dose-dependently potentiates GABA-activated currents in these neurons and blocks NMDA-activated potentiation in cortical and hippocampal neurons. The peptide modulates activity of presynaptic NMDA receptors, which is seen from changes in 45Ca2+ uptake into synaptosomes of the brain cortex after uptake stimulation with glutamate and NMDA.

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Authors and Affiliations

  1. Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka

    V. V. Grigor’ev, T. A. Ivanova, E. A. Kustova, L. N. Petrova, T. P. Serkova & S. O. Bachurin

Authors
  1. V. V. Grigor’ev
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  2. T. A. Ivanova
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  3. E. A. Kustova
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  4. L. N. Petrova
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  5. T. P. Serkova
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  6. S. O. Bachurin
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 8, pp. 149–151, August, 2006

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Grigor’ev, V.V., Ivanova, T.A., Kustova, E.A. et al. Effects of delta sleep-inducing peptide on pre-and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats. Bull Exp Biol Med 142, 186–188 (2006). https://doi.org/10.1007/s10517-006-0323-9

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  • DOI: https://doi.org/10.1007/s10517-006-0323-9

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