Abstract
Morphological composition of the bone marrow, content of hemopoietic precursors, intensity of their proliferation and differentiation, and the size of mesenchymal precursor pool were studied in experiments on CBA/CaLac mice with myelosuppression induced by adriamycin, cyclophosphamide, or 5-fluorouracil in the maximum tolerated doses. The dynamics of changes in the content of granulomonocyte precursors in the bone marrow after cytostatic treatment was similar to that of erythroid precursors. Changes in the content of stromal mechanocytes were specific for each cytostatic. Different character of the reaction of the hemopoietic and mesenchymal stem cells to the test cytostatics was demonstrated.
Similar content being viewed by others
REFERENCES
M. L. Gershanovich, Complication during Chemiotherapy and Hormone Therapy of Tumors [in Russian], Moscow (1982).
E. D. Goldberg, A. M. Dygai, and V. V. Zhdanov, Role of Hemopoiesis-Inducing Environment in Regulation of Hemopoiesis during Cytostatic-Induced Myelosuppressions [in Russian], Tomsk (1999).
E. D. Goldberg, A. M. Dygai, V. P. Shakhov, Method of Tissue Culture in Hematology [in Russian], Tomsk (1992).
E. D. Goldberg, A. M. Dygai, and E. Yu. Sherstoboev, Mechanisms of Local Regulation of Hemopoiesis [in Russian], Tomsk (2000).
A. M. Dygai, V. V. Zhdanov, I. V. Bogdashin, and V. E. Goldberg, Biol. Nauki, No. 9, 109–116 (1992).
A. M. Dygai, N. A. Klimenko, Inflammation and Hemopoiesis [in Russian], Tomsk (1992).
Laboratory Methods in Clinical Practice: Manual, Ed. V. V. Men’shikov [in Russian], Moscow (1987).
N. I. Perevodchikova, Antitumor Chemiotherapy [in Russian], Moscow (1993).
V. V. Serov and A. B. Shekhter, Connective Tissue [in Russian], Moscow (1981).
A. Ya. Fridenshtein and E. A. Luriya, Cells of Hemopoietic Environment [in Russian], Moscow (1980).
P. S. Anker, W. A. Noort, S. A. Scherjon, et al., Haematologica, 88, 845–852 (2003).
A. Chapel, J. M. Bertho, M. Bensidhoum, et al., J. Gene Med., 5, No.12, 1028–1038 ( 2003).
D. Cilloni, C. Carlo-Stella, F. Falzetti, et al., Blood, 96, No.10, 3637–3643 (2000).
D. T. Covas, J. L. C. Siufi, A. R. L. Silva, and M. D. Orellana, Braz. J. Med. Biol. Res., 36, No.9, 1179–1183 (2003).
H. Kim, J.-H. Lee, and H. Suh, Yonsei Med. J., 44, No.2, 187–197, (2003).
J. J. Minguell, A. Erices, and P. Conget, Exp. Biol. Med., 226, 507–520 (2001).
N. Zvaifler, L. Marinova-Mutafchieva, G. Adams, et al., Arthritis Res., 2, No.6, 477–488 (2000).
Author information
Authors and Affiliations
Additional information
Translated from Kletochnye Tekhnologii v Biologii i Meditsine, Vol. 1, No. 1, pp. 20–24, January, 2005
Rights and permissions
About this article
Cite this article
Goldberg, E.D., Dygai, A.M. & Zhdanov, V.V. Effect of cytostatics on bone marrow stem cells. Bull Exp Biol Med 139, 121–125 (2005). https://doi.org/10.1007/s10517-005-0228-z
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0228-z