Skip to main content
SpringerLink
Log in

A novel filtration method integrated on centrifugal microfluidic devices

  • Short Communication
  • Published:
Microfluidics and Nanofluidics Aims and scope Submit manuscript

Abstract

A method has been developed that integrates filters directly into centrifugal microfluidic devices. This technique is suitable for both rapid prototyping and commercial applications. Commercially available filter paper was sealed into the centrifugal microfluidic device with a simple manual fabrication procedure. The method was validated using soil slurry in water and a variety of filter papers with pore sizes ranging from 0.7 to 11 μm. Filtration times of 4 s to several minutes were obtained for 100 μL samples depending on the type of filter paper and rotation rate utilized. The validity of the method was demonstrated by assessing the amount of light lost due to the scatter or absorption caused by particles in the filtered sample while the device was in motion. Filtration and sedimentation were compared and after 30 min of centrifugation, sedimentation had not removed particles as well as filtration. This technique opens up centrifugal microfluidic devices to a wide range of samples.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

References

  • Arora A, Simone G, Salieb-Beugelaar GB, Kim JT, Manz A (2010) Latest developments in micro total analysis systems. Anal Chem 82(12):4830–4847

    Article  Google Scholar 

  • Bouchard AP, Duford DA, Salin ED (2010) Non-contact addition, metering, and distribution of liquids into centrifugal microfluidic devices in motion. Anal Chem 82(20):8386–8389

    Article  Google Scholar 

  • Duffy DC, Gillis HL, Lin J, Sheppard NF Jr, Kellogg GJ (1999) Microfabricated centrifugal microfluidic systems: characterization and multiple enzymatic assays. Anal Chem 71(20):4669–4678

    Article  Google Scholar 

  • Duford DA (2012) Instrumentation, fabrication techniques and method development for sample induction, preparation and extraction on centrifugal microfluidic devices in motion. McGill University, Doctor of Philosophy

    Google Scholar 

  • Duford DA, Peng DD, Salin ED (2009) Magnetically driven solid sample preparation for centrifugal microfluidic devices. Anal Chem 81(11):4581–4584

    Article  Google Scholar 

  • Gorkin R, Park J, Siegrist J, Amasia M, Lee BS, Park JM, Kim J, Kim H, Madou M, Cho YK (2010) Centrifugal microfluidics for biomedical applications. Lab Chip 10(14):1758–1773

    Article  Google Scholar 

  • Gorkin R III, Nwankire CE, Gaughran J, Zhang X, Donohoe GG, Rook M, O’Kennedy R, Ducree J (2012) Centrifugo-pneumatic valving utilizing dissolvable films. Lab Chip 12(16):2894–2902

    Article  Google Scholar 

  • Karle M, Wohrle J, Von Stetten F, Zengerle R, Mark D (2013) Axial centrifugal filtration—a novel approach for rapid bacterial concentration from a large volume. In: Transducers, Barcelona, Spain, p 16–20, June 2013, IEEE

  • Lacroix-Fralish A, Templeton EJ, Salin ED, Skinner CD (2009) A rapid prototyping technique for valves and filters in centrifugal microfluidic devices. Lab Chip 9(21):3151–3154

    Article  Google Scholar 

  • Lafleur JP, Salin ED (2009) Pre-concentration of trace metals on centrifugal microfluidic discs with direct determination by laser ablation inductively coupled plasma mass spectrometry. J Anal At Spectrom 24(11):1511–1516

    Article  Google Scholar 

  • Madou M, Zoval J, Jia G, Kido H, Kim J, Kim N (2006) Lab on a CD. Annu Rev Biomed Eng 8:601–628

    Article  Google Scholar 

  • Mark D, Haeberle S, Roth G, Von Stetten F, Zengerle R (2010) Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. Chem Soc Rev 39(3):1153–1182

    Article  Google Scholar 

  • Ríos Á, Zougagh M (2013) Sample preparation for micro total analytical systems (μ-TASs). Trends Analyt Chem 43:174–188

    Article  Google Scholar 

  • Ríos Á, Zougagh M, Avila M (2012) Miniaturization through lab-on-a-chip: utopia or reality for routine laboratories? A review. Anal Chim Acta 740:1–11

    Article  Google Scholar 

  • Skinner CD, Salin ED (1995) Determination of lead in soils surrounding a lead-acid battery manufacturer. Water Qual Res J Can 30(2):299–304

    Google Scholar 

  • Steigert J, Grumann M, Brenner T, Mittenbuehler K, Nann T, Ruehe J, Moser I, Haeberle S, Riegger L, Riegler J, Bessler W, Zengerle R, Ducrée J (2005) Integrated sample preparation, reaction, and detection on a high-frequency centrifugal microfluidic platform. JALA 10(5):331–341

    Google Scholar 

  • Steigert J, Brenner T, Grumann M, Riegger L, Lutz S, Zengerle R, Ducrée J (2007) Integrated siphon-based metering and sedimentation of whole blood on a hydrophilic lab-on-a-disk. Biomed Microdevices 9(5):675–679

    Article  Google Scholar 

  • Xi Y, Duford DA, Salin ED (2010a) Automated liquid-solid extraction of pyrene from soil on centrifugal microfluidic devices. Talanta 82(3):1072–1076

    Article  Google Scholar 

  • Xi Y, Templeton EJ, Salin ED (2010b) Rapid simultaneous determination of nitrate and nitrite on a centrifugal microfluidic device. Talanta 82(4):1612–1615

    Article  Google Scholar 

  • Zoval JV, Madou MJ (2004) Centrifuge-based fluidic platforms. Proc IEEE 92(1):140–153

    Article  Google Scholar 

  • Zoval J, Jia G, Kido H, Kim J, Kim N, Madou MJ (2007) Centrifuge-based fluidic platforms. Springer Handbook of Nanotechnology (2nd Edition): pp 549–570

Download references

Acknowledgments

The authors gratefully acknowledge the National Science and Engineering Research Council of Canada for scholarship support for EJT and support under the Discovery Grant Program. The authors also thank Cameron D. Skinner for helpful conversations.

Author information

Authors and Affiliations

  1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 0B8, Canada

    Erin J. Templeton & Eric D. Salin

Authors
  1. Erin J. Templeton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric D. Salin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric D. Salin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Templeton, E.J., Salin, E.D. A novel filtration method integrated on centrifugal microfluidic devices. Microfluid Nanofluid 17, 245–251 (2014). https://doi.org/10.1007/s10404-013-1293-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10404-013-1293-7

Keywords

Search

Navigation