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PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis

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Abstract

Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome of rheumatoid arthritis (RA) patients, leading the migration of active macrophage. In contrast, markedly lower level of Hotair was detected in differentiated osteoclasts and rheumatoid synoviocytes and enforced expression of Hotair led to significantly decreased levels of MMP-2 and MMP-13. This exploratory study provides novel empirical evidence that Hotair could be one of potential biomarkers for diagnosing RA.

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Acknowledgments

This works was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A120152) and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MISP) [2011-0030130]. E-J Jin and M Lee were involved in study design, interpretation of the results and writing of the manuscript. J Song, D Kim, J Han, and Y Kim were involved in data collection and analysis, interpretation of the results.

Conflict of interest

None of the authors has any potential conflicts of interest.

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Authors and Affiliations

  1. Department of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Chunbuk, 570-749, Korea

    Jinsoo Song, Dongkyun Kim, Jiyeon Han, Yunha Kim & Eun-Jung Jin

  2. Division Rheumatology, Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, 570-749, Korea

    Myeungsu Lee

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  1. Jinsoo Song
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  2. Dongkyun Kim
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  3. Jiyeon Han
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  4. Yunha Kim
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  5. Myeungsu Lee
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  6. Eun-Jung Jin
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Corresponding authors

Correspondence to Myeungsu Lee or Eun-Jung Jin.

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Song, J., Kim, D., Han, J. et al. PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. Clin Exp Med 15, 121–126 (2015). https://doi.org/10.1007/s10238-013-0271-4

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  • DOI: https://doi.org/10.1007/s10238-013-0271-4

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