Abstract
Malignant mixed müllerian tumors (MMMT) of the fallopian tube are extremely rare, and optimal therapy for them is unknown. A 71-year-old woman presented to us with symptoms of abdominal distension and nausea. A right salpingo-oophorectomy was performed. Pathological examination determined International Federation of Gynecology and Obstetrics (FIGO) stage IIIc MMMT of the right fallopian tube. Of note, multiple tumoral nodules were attached to the sigmoid colon. The patient received three courses of chemotherapy, consisting of 175 mg/m2 paclitaxel and AUC = 5 carboplatin (TC therapy), administered at 3-week intervals. A second, debulking, surgery was then performed, consisting of total abdominal hysterectomy, left salpingo-oophorectomy, and pelvic and paraaortic lymphadenectomy. The tumor attached to the sigmoid colon had shrunk by 60% after chemotherapy. The patient received an additional five courses of adjuvant TC therapy. The patient is alive and free of disease 28 months after the debulking surgery. TC therapy may be effective for MMMT of the fallopian tube.
Similar content being viewed by others
References
Imachi M, Tsukamoto N, Shigematsu T, et al. (1992) Malignant mixed müllerian tumor of the fallopian tube: report of two cases and review of literature. Gynecol Oncol 47:114–124
Horn LC, Werschnik C, Bilek K, et al. (1996) Diagnosis and clinical management in malignant Müllerian tumors of the fallopian tube. Arch Gynecol Obstet 258:47–53
Gagner JP, Mittal K (2005) Malignant mixed müllerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma. Gynecol Oncol 97:219–222
Lim BJ, Kim JW, Yang WI, et al. (2004) Malignant mixed müllerian tumor of fallopian tube with multiple distinct heterologous components. Int J Gynecol Cancer 14:690–693
Carlson JA Jr, Ackerman BL, Wheeler JE (1993) Malignant mixed müllerian tumor of the fallopian tube. Cancer 71:187–192
Zorlu CG, Cobanoglu O, Kuscu E, et al. (1994) Malignant mixed müllerian tumor of the fallopian tube. Acta Obstet Gynecol Scand 73:352–354.
Mok JE, Kim YM, Jung MH, et al. (2006) Malignant mixed müllerian tumors of the ovary: experience with cytoreductive surgery and platinum-based combination chemotherapy. Int J Gynecol Cancer 16:101–105.
Hellstrom AC, Tegerstedt G, Silfversward C, et al. (1999) Malignant mixed müllerian tumors of the ovary: histopathologic and clinical review of 36 cases. Int J Gynecol Cancer 9:312–316.
Morrow CP, d’Ablaning G, Blady LW, et al. (1984) A clinical and pathologic study of 30 cases of malignant mixed mullerian epithelial and mesenchymal ovarian tumors: a Gynecologic Oncology Group study. Gynecol Oncol 18:278–292
Bicher A, Levenback C, Silva EG, et al. (1984) Ovarian malignant mixed mullerian tumors treated with platinum-based chemotherapy. Obstet Gynecol 85:735–739
Sillverberg SG, Major FJ, Blessing JA, et al. Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases. Int J Gynecol Pathol 9:1–19
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Kawaguchi, W., Itamochi, H., Kigawa, J. et al. Chemotherapy consisting of paclitaxel and carboplatin benefits a patient with malignant mixed müllerian tumor of the fallopian tube. Int J Clin Oncol 13, 461–463 (2008). https://doi.org/10.1007/s10147-008-0767-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10147-008-0767-1