Abstract
The aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MPV, complement 3 (C3), complement 4 (C4), urine protein (Up), and urine creatinine (Ucr) values upon reactivation and remission phases were recorded. MPV was statistically higher in patients than in controls and significantly increased in active phase compared to inactive phase (p = 0.001). A MPV level of 8.4 fL was determined as predictive cutoff value of activation of SLE (sensitivity 75 %, specificity 90 %). MPV was positively correlated with SLEDAI (p = 0.01, r = 0.55), ESR (p = 0.01, r = 0.45), CRP (p = 0.04, r = 0.24), and Up/Ucr (p = 0.01, r = 0.45) and negatively correlated with C3 (p = 0.02, r = −0.36), albumin (p = 0.01, r = −0.63), and Hb (p = 0.01, r = −0.48). There was not any significant association between MPV and the histological classification of lupus nephritis (p = 0.65). MPV might be used as an early indicator of reactivation in children with SLE. MPV seemed to be more accurate than ESR, CRP, and C3 for monitoring the disease activity in SLE.
Similar content being viewed by others
References
Levy DM, Kamphuis S (2012) Systemic lupus erythematosus in children and adolescents. Pediatr Clin North Am 59:345–364
Tucker LB, Uribe AG, Férnandez M, Vilá LM, McGwin G, Apte M, Fessler BJ, Bastian HM, Reveille JD, Alarcón GS (2008) Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case-control study within LUMINA, a multiethnic US chort (LUMINA LVII). Lupus 17:314–322
Watson L, Leone V, Pilkington C, UK Juvenile-Onset Systemic Lupus Erythematosus Study Group et al (2012) Disease activity, severity, and damage in the UK Juvenile-Onset Systemic Lupus Erythematosus Cohort. Arthritis Rheum 64:2356–2365
Liu CC, Ahearn JM (2009) The search for lupus biomarkers. Best Pract Res Clin Rheumatol 23:507–523
Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17:47–58
Kisacık B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, Kiraz S, Ertenli I, Calguneri M (2008) Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 75:291–294
Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, Ataoglu S (2010) The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets 21:122–125
Ceylan B, Fincanci M, Yardimci C, Eren G, Tözalgan Ü, Müderrisoğlu C, Paşaoğlu E (2013) Can mean platelet volume determine the severity of liver fibrosis or inflammation in patients with chronic hepatitis B? Eur J Gastroenterol Hepatol 25:606–612
Sakallı H, Kal O (2013) Mean platelet volume as a potential predictor of proteinuria and amyloidosis in familial Mediterranean fever. Clin Rheumatol 32:1185–1190
Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Artritis Rheum 40:1725
Weening JJ, D’Agati VD, Schwartz MM et al (2004) The classification of glomerulonephritis in systemic lupus erythematosis revisited. J Am Soc Nephrol 15:241–250
Hawker G, Gabriel S, Bombardier C, Goldsmith C, Caron D, Gladman D (1993) A reliability study of SLEDAI: a disease activity index for systemic lupus erythematosus. J Rheumatol 20:657–660
Binder E, Edelbauer M (2013) Use of biomarkers in the management of children with lupus. Curr Rheumatol Rep 15:312
Watson E, Beresford MW (2013) Urine biomarkers in juvenile-onset SLE nephritis. Pediatr Nephrol 28:363–374
Turner-Stokes L, Jones D, Patterson KG, Todd-Pokropek A, Isenberg DA, Goldstone AH (1991) Measurement of haematoogical indices of chronic rheumatic disease with two newer generation automated systems, the H1 and H6000 (Technicon). Ann Rheum Dis 50:583–587
Campos LM, Kiss MH, Scheinberg MA, Mangueira CL, Silva CA (2006) Antinucleosome antibodies in pateints with juvenile systemic lupus erythematosus. Lupus 15:496–500
Stojan G, Fang H, Magder L, Petri M (2013) Erythrocyte sedimentation rate is a predictor of renal and overall disease activity. Lupus 22:827–834
Christopher-Stine L, Siedner M, Lin J, Haas M, Parekh H, Petri M, Fine DM (2007) Renal biopsy in lupus patients with low levels of proteinuria. J Rheumatol 34:332–335
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yavuz, S., Ece, A. Mean platelet volume as an indicator of disease activity in juvenile SLE. Clin Rheumatol 33, 637–641 (2014). https://doi.org/10.1007/s10067-014-2540-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-014-2540-3