Zusammenfassung
In der Literatur wird das autogene Knochentransplantat noch immer für viele Eingriffe in der Mund-, Kiefer- und Gesichtschirurgie als der „Goldstandard“ angesehen. In diesem Übersichtsartikel wird die Stellung des autogenen Knochentransplantates unter Berücksichtigung von aktuellen Forschungsergebnissen und Langzeitstudien, Patientensicherheit und -risiken sowie Kostengesichtspunkten kritisch diskutiert. Besonders durch die Weiterentwicklung von Knochenersatzmaterialien, welche in Langzeitstudien z.T. überlegene Resultate liefern, muss der routinemäßige Einsatz von autogenen Knochentransplantaten neu überdacht werden.
Abstract
Autogenous bone transfer is still regarded as the “golden standard” for many indications in oral and cranio-maxillofacial surgery. In this overview, the status of the autogenous bone is re-evaluated under consideration of current research results, clinical long-term studies, risks and safety of the patient as well as the costs. Due to the further development of modern bone substitute materials, which reveal in parts superior long-term results for special indications, the routine use of autogenous bone has to be critically reviewed.
Literatur
Artzi Z, Weinreb M, Givol N, Rohrer MD, Nemcovsky CE, Prasad HS, Tal H (2004) Biomaterial resorption rate and healing site morphology of inorganic bovine bone and beta-tricalcium phosphate in the canine: a 24-month longitudinal histologic study and morphometric analysis. Int J Oral Maxillofac Implants 19:357–368
Bauer TW, Muschler GF (2000) Bone graft materials: An overview of the basic science. Clin Orthop 371:10–27
Block MS, Kent JN (1997) Sinus augmentation for dental implants: The use of autogenous bone. J Oral Maxillofac Surg 55:1281–1286
Burchardt H (1983) The biology of bone graft repair. Clin Orthop Relat Res 174:28–42
Cordaro L (2003) Bilateral simultaneous augmentation of the maxillary sinus floor with particulated mandible. Report of a technique and preliminary results. Clin Oral Implants Res 14:201–206
Craft PD, Sargent LA (1989) Membranous bone healing and techniques in calvarial bone grafting. Clin Plast Surg 16:11–9
Daelemans P, Hermans M, Godet F, Malevez C (1997) Autologous bone graft to augment the maxillary sinus in conjunction with immediate endosseous implants: a retrospective study up to 5 years. Int J Periodontics Restorative Dent 17:27–39
de Groot K, Tencer A, Waite P, Nichols J, Kay J (1988) Significance of the porosity and physical chemistry of calcium phosphate ceramics. Dental and other head and neck uses. Ann NY Acad Sci 523:272–277
Donovan MG, Dickerson NC, Hellstein JW, Hanson LJ (1993) Autologous calvarial and iliac onlay bone grafts in miniature swine. J Oral Maxillofac Surg 51:898–903
Donovan MG, Dickerson NC, Hanson LJ, Gustafson RB (1994) Maxillary and mandibular reconstruction using calvarial bone grafts and Branemark implants: a preliminary report. J Oral Maxillofac Surg 52:588–594
Garg AK (1999) Augmentation grafting of the maxillary sinus for placement of dental implants: Anatomy, physiology, and procedures. Implant Dentistry 8:36–45
Goulet JA, Senunas LE, DeSilva GL, Greenfield ML (1997) Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res 339:76–81
Günther K, Scharf H, Pesch H, Puhl W (1998) Einwachsverhalten von Knochenersatzstoffen. Orthopädie 27:105–117
Hardesty RA, Marsh JL (1990) Craniofacial onlay bone grafting: a prospective evaluation of graft morphology, orientation, and embryonic origin. Plast Reconstr Surg 85:5–14
Hirsch JM, Ericsson I (1991) Maxillary sinus augmentation using mandibular bone grafts and simultaneous installation of implants. A surgical technique. Clin Oral Implants Res 2:91–96
Horch H-H, Steegmann B (1985) Experience with resorbable TCP-ceramic granules for the filling of large bone defects after cystectomy in the jaw. Dtsch Zahnärztl Z 40:672–677
Horch H-H, Sader R, Kolk A (2004) Synthetische, phasenreine Beta-Trikalziumphosphat-Keramik (Cerasorb) zur Knochenregeneration bei der rekonstruktiven Chirurgie der Kiefer – Eine klinische Langzeitstudie mit Literaturübersicht. Dtsch Zahnärztl Z 12:680–686
Jäger M, Fischer J, Schultheis A, Lensing-Hohn S, Krauspe R (2006) Extensive H(+) release by bone substitutes affects biocompatibility in vitro testing. J Biomed Mater Res A 76:310–322
Jäger M, Westhoff B, Wild A, Krauspe R (2005) Knochenspahnentnahme am Becken. Techniken und Probleme. Der Orthopäde 34:976–994
Jerosch J, Bader A, Uhr G (2002) Knochen. curasan Taschenatlas spezial. Thieme, Stuttgart, New York
Joshi A, Kostakis GC (2004) An investigation of post-operative morbidity following iliac crest graft harvesting. British Dental J 196:167–171
Kessler P, Thorwarth M, Bloch-Birkholz A, Nkenke E, Neukam FW (2005) Harvesting of bone from the iliac crest – comparison of the anterior and posterior sites. British J Oral Maxillofac Surg 43:51–56
Le Lorc'h-Bukiet I, Tulasne JF, Llorens A, Lesclous P (2005) Parietal bone as graft material for maxillary sinus floor elevation: structure and remodelling of the donor and of recipient sites. Clin Oral Implants Res16:244–249
Lin KY, Bartlett SP, Yaremchuk MJ, Fallon M, Grossman RF, Whitaker LA (1990) The effect of rigid fixation on the survival of onlay bone grafts: an experimental study. Plast Reconstr Surg 86:449–456
Lorenzetti M, Mozzati M, Campanino PP, Valente G (1998) Bone augmentation of the inferior floor of the maxillary sinus with autogenous bone or composite bone grafts: a histologic-histomorphometric preliminary report. Int J Oral Maxillofac Implants 13:69–76
Lundgren S, Moy P, Johansson C, Nilsson H (1996) Augmentation of the maxillary sinus floor with particulated mandible: a histologic and histomorphometric study. Int J Oral Maxillofac Implants 11:760–766
Maurer P, Schubert J (2004) Intraorale Knochenspendeareale in der zahnärztlichen Chirurgie. Quintessenz 12:1–7
Marx RE, Garg AK (1998) Bone structure, metabolism, and physiology: its impact on dental implantology. Implant Dent 7:267–276
Mazok JB, Schow SR, Triplett RG (2003) Posterior iliac crest bone harvest: Review of technique, complications, and postoperative pain control. J Oral Maxillofac Surg 61:1497–1503
Merten HA, Gruber RM, Nitsch A, Ludwig A, Schliephake H (2003) Evaluation oralchirurgischer Augmentationsmaterialien – Ein tierexperimentell-histomorphologischer Vergleich. Implantologie 11:215–236
Misch C, Jensen OT, Cockrell R (1999) Autogenous free bone graft harvesting for sinus floor and alveolar reconstruction. In: Jensen OT (ed.) The sinus bone graft. Quintessence, Chicago, 117–128
Muschler GF, Lane JM (1992) Orthopedic Surgery. In: Habal MB, Reddi AH (eds.) Bone Grafts and Bone Substitutes. WB Saunders Co, Philadelphia, 1573–1589
Neukam FW, Buser D. (1996) Implantate bei unzureichendem Knochenangebot. In: Koeck B, Wagner W (eds.) Implantologie. 1. Ed. München,Wien,Baltimore: Urban&Schwarzenberg, 177–218
Niedhart C, Pingsmann A, Jürgens C, Marr A, Blatt R, Niethard FU (2003) Komplikationen nach Entnahme autologen Knochens aus dem ventralen und dorsalen Beckenkamm – eine prospektive, kontrollierte Studie. Z Orthop 141, 481–486
Nkenke E, Radespiel-Tröger M, Wiltfang J, Schultze-Mosgau S, Winkler G, Neukam FW (2002) Morbidity of harvesting of retromolar bone grafts: a prospective study. Clin Oral Impl Res 13:514–521
Nkenke E, Weisbach V, Winckler E, Kessler P, Schultze-Mosgau S, Wiltfang J, Neukam FW (2004) Morbidity of harvesting of bone grafts from the iliac crest for prosthetic augmentation procedures: A prospective study. Int J Oral Maxillofac Surg 33:157–163
Ogose A, Hotta T, Kawashima H, Kondo N, Gu W, Kamura T, Endo N (2005) Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors. J Biomed Mater Res B Appl Biomater 72:94–101
Olson JW, Dent CD, Dominici JT, Lambert PM, Bellome J, Bichara J, Morris HF (1997) The influence of maxillary sinus augmentation on the success of dental implants through second-stage surgery. Implant Dent 6:225–228
Pautke C, Vogt S, Tischer T, Wexel G, Deppe H, Milz S, Schieker M, Kolk A (2005) Polychrome labeling of bone with seven different fluorochromes: Enhancing fluorochrome discrimination by spectral image analysis. Bone 37:441–445
Park JE, Barbul A (2004) Understanding the role of immune regulation in wound healing. Am J Surg 187:11S-16S
Phillips JH, Rahn BA (1988) Fixation effects on membranous and endochondral onlay bone-graft resorption. Plast Reconstr Surg 82:872–877
Peleg M, Garg AK, Misch CM, Mazor Z (2004) Maxillary sinus and ridge augmentations using a surface-derived autogenous bone graft. J Oral Maxillofac Surg 62:1535–1544
Pikos MA (1999) Alveolar ridge augmentation with ramus buccal shelf autografts and impacted third molar removal. Dent Implantol Update 10:27–31
Raghoebar GM, Brouwer TJ, Reintsema H, Van Oort RP (1993) Augmentation of the maxillary sinus floor with autogenous bone for the placement of endosseous implants: a preliminary report. J Oral Maxillofac Surg 51:1198–1203
Reich RH, Appel T, Martini M, Lückerath W (2005) Improvement of implants in sinus grafts by the use of alloplastic bone replacement materials. Int J Artificial Org 28:335
Riediger D (1988) Restorations of masticastory function by microsurgically revascularized iliac crest bone grafts using enosseous implants. Plast Reconstr Surg 81:861–876
Schenk C, Schwarz A, Kaupe AJM, Wiltfang J, Neukam FW (2000) Erfahrungen mit autogenen Beckenkammtransplantationen im Ober- und Unterkiefer. Dtsch Zahnärztl Z 55:355–358
Schimming R, Schmelzeisen R (2004) Tissue-engineered bone for maxillary sinus augmentation. J Oral Maxillofac Surg 62:724–9
Schnee CL, Freese A, Weil RJ, Marcotte PJ (1997) Analysis of harvest morbidity and radiographic outcome using autograft for anterior cervical fusion. Spine 22:2222–2227
Smiler DG, Johnson PW, Lozada JL, Misch C, Rosenlicht JL, Tatum OH Jr, Wagner JR (1992) Sinus lift grafts and endosseous implants. Treatment of the atrophic posterior maxilla. Dent Clin North Am 36:151–186
St John TA, Vaccaro AR, Sah AP, Schaefer M, Berta SC, Albert T, Hilibrand A (2003) Physical and monetary costs associated with autogenous bone graft harvesting. Am J Orthop 32:18–23
Summers BN, Eisenstein SM (1989) Donor site pain from the ilium. A complication of lumbar spine fusion. J Bone Joint Surg Br 71:677–680
Szabó G, Huys L, Coulthard P, Maiorana C, Garagiola U, Barabás J, Németh Z, Hrabák K, Suba Z (2005) A Prospective Multicenter Randomized Clinical Trial of Autogenous Bone Versus ß-Tricalcium Phosphate Graft Alone for Bilateral Sinus Elevation: Histologic and Histomorphometric Evaluation. Int J Oral Maxillofac Implants 20:371–381
Thorwarth M, Schlegel KA, Wiltfang J, Rupprecht S, Park JH (2004) Experimental pilot study on surface activation of implants with liposomal vectors. Mund Kiefer Gesichtschir 8:250–255
Tulasne JF (1999) Sinus grafting with calvarian bone. In: Jensen OT (ed) The sinus bone graft. Quintessence, Chicago, 107–116
Uchida Y, Goto M, Katsuki T, Soejima Y (1998) Measurement of maxillary sinus volume using computerized tomographic images. Int J Oral Maxillofac Implants 13:811–818
Urist MR, Dowell TA, Hay PH, Strates BS (1968) Inductive substrates for bone formation. Clin Orthop Relat Res 59:59–96
Urist MR (1997) Bone morphogenetic protein: the molecularization of skeletal system development. J Bone Miner Res 12:343–346
Warnke T, Glauser R, Schüpach P, Carls FR, Zimmermann AP, Schärer P, Sailer HF (2000) Klinische, radiologische und histomorphometrische Auswertung der Oberkieferaugmentationen (Bio-Oss) mit Sinuslift. Dtsch Zahnärztl Z 55:340–343
Warnke PH, Springer IN, Russo PA, Wiltfang J, Essig H, Kosmahl M, Sherry E, Acil Y (2005) Innate immunity in human bone. Bone. 2005 Oct 28 [Epub]
Warnke PH, Springer IN, Wiltfang J, Acil Y, Eufinger H, Wehmoller M, Russo PA, Bolte H, Sherry E, Behrens E, Terheyden H (2004) Growth and transplantation of a custom vascularised bone graft in a man. Lancet 364:766–770
Wenz B, Ackermann KL (2003) Ist die Sinusbodenaugmentation mit Knochenersatzmaterial erfolgreich durchführbar? Dent Implantol 7:376–385
Williamson RA (1996) Rehabilitation of the resorbed maxilla and mandible using autogenous bone grafts and osseointegrated implants. Int J Oral Maxillofac Implants 11:476–488
Wilkes GH, Kernahan DA, Christenson M (1985) The long-term survival of onlay bone grafts – a comparative study in mature and immature animals. Ann Plast Surg 15:374–378
Wiltfang J, Schulze-Mosgau S, Nkenke E, Thorwarth M, Neukam FW, Schlegel KA (2005) Onlay augmentation versus sinuslift procedure in the treatment of the severely resorbed maxilla: a 5-year comparative longitudinal study. Int J Oral Maxillofac Surg 34:885–889
Wippermann BW, Schratt H-E, Steeg S, Tscherne H (1997) Komplikationen der Spongiosaentnahme am Beckenkamm. Eine retrospektive Analyse von 1191 Fällen. Chirurg 68:1286–1291
Wood RM, Moore DL (1988) Grafting of the maxillary sinus with intraorally harvested autogenous bone prior to implant placement. Int J Oral Maxillofac Implants 3:209–214
Yang B, Zhao M, Xiong B (1999) Histological study and stereologic analysis of membranous versus endochondral onlay bone grafts. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 15:280–282
Younger EM, Chapman MW (1989) Morbidity at bone graft donor sites. J Orthop Trauma 3:192–195
Zerbo IR, Lange GL, Joldersman M, Bronckers A LJJ, Burger EH (2003) The fate of monocortical bone blocks grafted in the human maxilla: A histological and histomorphometric study. Clin Oral Impl Res 14:759–766
Zijderveld S, Zerbo IR, van den Bergh JP, Schulten EAJM, ten Bruggenkate CM (2005) Maxillary Sinus Floor Augmentation Using a ß-Tricalcium Phosphate (Cerasorb) Alone Compared to Autogenous Bone Grafts. Int J Oral Maxillofac Implants 20:432–440
Zins JE, Whitaker LA (1983) Membranous versus endochondral bone: implications for craniofacial reconstruction. Plast Reconstr Surg 72:778–785
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Horch, HH., Pautke, C. Regeneration statt Reparation. Mund Kiefer GesichtsChir 10, 213–220 (2006). https://doi.org/10.1007/s10006-006-0004-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10006-006-0004-x