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Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease

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Summary.

There is increasing interest in the identification of biological markers for the early diagnosis of Parkinson's disease (PD). Previous studies indicate changes of dopamine content, tyrosine hydroxylase immunoreactivity and dopamine receptors in peripheral blood lymphocytes (PBL) in PD. Here we demonstrate a reduction of dopamine transporter immunoreactivity in PBL in the early clinical stages of the disease. These findings contribute to our understanding of the peripheral dopamine system in PD.

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Authors and Affiliations

  1. Department of Neuroscience, University "La Sapienza", and, , , , , , IT

    B. Caronti, G. Antonini, C. Calderaro, G. Palladini, F. E. Pontieri & C. Colosimo

  2. INM "Neuromed", Pozzilli (IS), Italy, , , , , , IT

    S. Ruggieri

Authors
  1. B. Caronti
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  2. G. Antonini
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  3. C. Calderaro
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  4. S. Ruggieri
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  5. G. Palladini
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  6. F. E. Pontieri
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  7. C. Colosimo
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Additional information

Received November 16, 2000; accepted March 19, 2001

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Caronti, B., Antonini, G., Calderaro, C. et al. Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. J Neural Transm 108, 803–807 (2001). https://doi.org/10.1007/s007020170030

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  • DOI: https://doi.org/10.1007/s007020170030

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