Abstract
Several evidences suggested that the serotonin 5-HT1B receptor gene (HRT1B) might be involved in the susceptibility to attention deficit/hyperactivity disorder (ADHD). Prior studies reported excess transmissions of the HRT1B gene 861G allele to affected ADHD children and of a haplotype block containing this variant and two functional promoter SNPs to probands with ADHD-inattentive subtype. However, some investigations did not replicate these findings. Therefore, we tested for biased transmissions of haplotypes derived from the 861G > C, –161A > T, and –261T > G SNPs from parents to 343 families with ADHD children. We also sought to replicate findings from the literature that the association between HTR1B is preferentially with ADHD-Inattentive subtype. Using a transmission disequilibrium test we found evidence for an excess transmission of haplotype. –261G/–161T/861G (P = 0.014) for affected children in the total sample. When the analysis was repeated with 143 families with ADHD-Inattentive subtype no significant associations were observed. Our results provide additional evidence that HRT1B gene may be an important risk factor for the development of ADHD, but this effect seems not to be attributable to inattentive cases.
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Acknowledgments
The authors thank the financial support provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), Institutos do Milênio (CNPq), PRONEX, and Fundação de Amparo a Pesquisa do Estado do Rio Grande do Sul.
Conflict of interest: Dr L.A. Rohde was on the speakers’ bureau and/or acted as consultant for Eli-Lilly, Janssen-Cilag, and Novartis in the past 3 years. Currently, his only industry-related activity is taking part in the advisory board/speakers bureau for Eli-Lilly & Company. The ADHD Outpatient Program receives unrestricted educational and research support from the following pharmaceutical companies: Bristol-Myers Squibb, Eli-Lilly, Janssen-Cilag, and Novartis. Guilherme Polanczyk is on the speakers’ bureau of Novartis. Cristian Zeni: The ADHD and Juvenile Bipolar Disorder Outpatient Programs receive research support from the following pharmaceutical companies: Abbott Laboratories, Bristol-Myers Squibb, Eli-Lilly, Janssen-Cilag, and Novartis.
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Guimarães, A.P., Schmitz, M., Polanczyk, G.V. et al. Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B gene. J Neural Transm 116, 1675–1680 (2009). https://doi.org/10.1007/s00702-009-0305-y
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DOI: https://doi.org/10.1007/s00702-009-0305-y