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Metal organic framework HKUST-1 modified with carboxymethyl-β-cyclodextrin for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs

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A Correction to this article was published on 15 August 2019

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Abstract

This work shows that the metal organic framework (MOF) HKUST-1 of type Cu3(BTC)2 (also referred to as MOF-199; a face-centered-cubic MOF containing nanochannels) is a most viable coating for use in enantioseparation in capillary electrochromatography (CEC). A HKUST-1 modified capillary was prepared and characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectra, elemental analysis and thermogravimetric analysis. CEC-based enantioseparation of the basic drugs propranolol (PRO), esmolol (ESM), metoprolol (MET), amlodipine (AML) and sotalol (SOT) was performed by using carboxymethyl-β-cyclodextrin as the chiral selector. Compared with a fused-silica capillary, the resolutions are improved (ESM: 1.79; MET: 1.80; PRO: 4.35; SOT: 1.91; AML: 2.65). The concentration of chiral selector, buffer pH value, applied voltage and buffer concentration were optimized, and the reproducibilities of the migration times and Rs values were evaluated.

Schematic presentation of the preparation of a HKUST-1@capillary for enantioseparation of racemic drugs. Cu(NO3)2 and 1,3,5-benzenetricarboxylic acid (BTC) were utilized to prepare the HKUST-1@capillary. Then the capillary was applied to construct capillary electrochromatography system with carboxymethyl-β-cyclodextrin (CM-β-CD) for separation of basic racemic drugs.

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Change history

  • 15 August 2019

    The published version of this article, unfortunately, contains error. The author found out that the given name interchanged with the family name. The second author’s family name should be “Yu” and the first name should be “Tao”. Given in this article is the correct author name.

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Acknowledgements

This work was supported by the Natural Science Foundation of Jiangsu Province (Program No.: BK20141353).

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Authors and Affiliations

  1. Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing, 210009, People’s Republic of China

    Xiaodong Sun, Yu Tao, Yingxiang Du, Wen Ding, Cheng Chen & Xiaofei Ma

  2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, Jiangsu, 210009, People’s Republic of China

    Xiaodong Sun, Yu Tao, Yingxiang Du, Wen Ding, Cheng Chen & Xiaofei Ma

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  1. Xiaodong Sun
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  2. Yu Tao
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  3. Yingxiang Du
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  4. Wen Ding
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  5. Cheng Chen
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  6. Xiaofei Ma
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Correspondence to Yu Tao or Yingxiang Du.

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Sun, X., Tao, Y., Du, Y. et al. Metal organic framework HKUST-1 modified with carboxymethyl-β-cyclodextrin for use in improved open tubular capillary electrochromatographic enantioseparation of five basic drugs. Microchim Acta 186, 462 (2019). https://doi.org/10.1007/s00604-019-3584-5

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