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Primary extragastrointestinal stromal tumor arising in the pancreas: report of a case

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Abstract

Primary extragastrointestinal stromal tumors (EGISTs) arising in the pancreas are extremely rare, with only ten cases documented to our knowledge. We report a further case of EGIST of the pancreas. The patient was a 55-year-old man who presented with postprandial abdominal discomfort. Abdominal computed tomography and magnetic resonance imaging showed a lobulated heterogenous enhancing mass, 11 cm in diameter, in the abdominal cavity. No regional lymphadenopathy, ascites, or metastasis was seen radiologically. There was no obvious lesion in the stomach or small intestine. The initial diagnosis was a solid pseudopapillary tumor or serous cystic neoplasm. The patient underwent distal pancreatectomy with splenectomy. Microscopically, the tumor consisted of spindle cells arranged in short fascicles. Mitotic figures were seen in 7/50 high-power fields. Immunohistochemical examination revealed strongly positive staining for CD117. Based on these findings, the final pathologic diagnosis was a primary EGIST of the pancreas. This case consolidates the possibility that this rare tumor can involve the pancreas as a primary site and should be included in the differential diagnosis of cystic lesions in this site.

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References

  1. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130:1466–78.

    PubMed  CAS  Google Scholar 

  2. Padhi S, Kongara R, Uppin SG, Uppin MS, Prayaga AK, Challa S, et al. Extragastrointestinal stromal tumor arising in the pancreas: a case report with a review of the literature. JOP. 2010;11:244–8.

    PubMed  Google Scholar 

  3. Ortiz-Hidalgo C, de Leon Bojorge B, Albores-Saavedra J. Stromal tumor of the gallbladder with phenotype of interstitial cells of Cajal: a previously unrecognized neoplasm. Am J Surg Pathol. 2000;24:1420–3.

    Article  PubMed  CAS  Google Scholar 

  4. Hirashima K, Takamori H, Hirota M, Tanaka H, Ichihara A, Sakamoto Y, et al. Multiple gastrointestinal stromal tumors in neurofibromatosis type 1: report of a case. Surg Today. 2009;39:979–83.

    Article  PubMed  Google Scholar 

  5. Neto MR, Machuca TN, Pinho RV, Yuasa LD, Bleggi-Torres LF. Gastrointestinal stromal tumor: report of two unusual cases. Virchows Arch. 2004;444:594–6.

    Article  PubMed  Google Scholar 

  6. Yamaura K, Kato K, Miyazawa M, Haba Y, Muramatsu A, Miyata K, et al. Stromal tumor of the pancreas with expression of c-kit protein: report of a case. J Gastroenterol Hepatol. 2004;19:467–70.

    Article  PubMed  Google Scholar 

  7. Krska Z, Peskova M, Povysil C, Horejs J, Sedlackova E, Kudrnova Z. GIST of pancreas. Prague Med Rep. 2005;106:201–8.

    PubMed  CAS  Google Scholar 

  8. Daum O, Klecka J, Ferda J, Treska V, Vanecek T, Sima R, et al. Gastrointestinal stromal tumor of the pancreas: case report with documentation of KIT gene mutation. Virchows Arch. 2005;446:470–2.

    Article  PubMed  Google Scholar 

  9. Showalter SL, Lloyd JM, Glassman DT, Berger AC. Extra-gastrointestinal stromal tumor of the pancreas: case report and a review of the literature. Arch Surg. 2008;143:305–8.

    Article  PubMed  Google Scholar 

  10. Yan BM, Pai RK, Van Dam J. Diagnosis of pancreatic gastrointestinal stromal tumor by EUS guided FNA. JOP. 2008;9:192–6.

    PubMed  Google Scholar 

  11. Harindhanavudhi T, Tanawuttiwat T, Pyle J, Silva R. Extra-gastrointestinal stromal tumor presenting as hemorrhagic pancreatic cyst diagnosed by EUS-FNA. JOP. 2009;10:189–91.

    PubMed  Google Scholar 

  12. Trabelsi A, Ben Yacoub-Abid L, Mtimet A, Ben Abdelkrim S, Hammedi F, Ben Ali A, et al. Gastrointestinal stromal tumor of the pancreas: a case report and review of the literature. North Am J Med Sci. 2009;1:324–6.

    Google Scholar 

  13. Saif MW, Hotchkiss S, Kaley K. Gastrointestinal stromal tumors of the pancreas. JOP 2010;11:405–6 (author reply 12).

    Google Scholar 

  14. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33:459–65.

    Article  PubMed  Google Scholar 

  15. Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13:577–85.

    Article  PubMed  CAS  Google Scholar 

  16. Gutierrez JC, De Oliveira LO, Perez EA, Rocha-Lima C, Livingstone AS, Koniaris LG. Optimizing diagnosis, staging, and management of gastrointestinal stromal tumors. J Am Coll Surg. 2007;205:479–91. (Quiz 524).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Chonnam National University Medical School, 160, Ilsim-ri, Hwasun-eup, Hwasun-gun, Jellanam-do, 519-809, Korea

    Ho-Hyun Kim, Yang-Seok Koh, Eun-Kyu Park, Jin-Shick Seoung, Young-Hoe Hur, Jung-Chul Kim, Chol-Kyoon Cho & Hyun-Jong Kim

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  1. Ho-Hyun Kim
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  2. Yang-Seok Koh
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Correspondence to Yang-Seok Koh.

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Kim, HH., Koh, YS., Park, EK. et al. Primary extragastrointestinal stromal tumor arising in the pancreas: report of a case. Surg Today 42, 386–390 (2012). https://doi.org/10.1007/s00595-011-0080-x

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