Zusammenfassung
Die quantitative sensorische Testung (QST) ist die standardisierte Erweiterung der klinisch-neurologischen Sensibilitätsprüfung. QST erlaubt eine vollständige Erfassung der Funktion aller sensorischer Submodalitäten. Im Gegensatz zur konventionellen Elektrophysiologie können positive und negative sensorische Veränderungen erfasst werden. Im Rahmen des Deutschen Forschungsverbundes Neuropathischer Schmerz (DFNS) wurden eine standardisierte QST-Testbatterie mit 13 Parametern etabliert und Normdaten erhoben. Die QST ist jedoch eine psychophysische Methode, die auch von der Mitarbeit des Patienten bzw. Probanden beeinflusst wird. Daher beinhaltet der standardisierte Untersuchungsablauf die einheitliche Instruktion und Applikation der Testreize, um die laborübergreifende Vergleichbarkeit der QST-Befunde/Messergebnisse zu ermöglichen.
Die Deutsche Gesellschaft zum Studium des Schmerzes (DGSS) hat daher in Zusammenarbeit mit dem DFNS Zertifizierungskriterien erarbeitet, um die Verbreitung der QST zu erleichtern. Die QST-Zertifizierung beinhaltet Kriterien zur Bewertung der Struktur-, Prozess- und Ergebnisqualität. Über die festgelegten Qualitätsstandards soll die QST-Zertifizierung nicht nur der Patientenversorgung zu gute kommen, sondern auch zur Verbesserung der Diagnostik in klinischen (Therapie-)Studien neuropathischer Schmerzsyndrome beitragen.
Abstract
Quantitative sensory testing (QST) is the standardized assessment of the somatosensory system comprising all sensory submodalities. In the German Research Network on Neuropathic Pain (DFNS), a QST-battery consisting of 13 parameters has been established and nationwide normative data have been collected. In contrast to conventional electrophysiology, QST allows detecting negative and positive sensory signs of both large and small fiber systems. However, as a subjective psychophysical method it is critically dependent on patients’ / healthy subjects’ cooperation thus strictly standardized protocols and instructions are needed to allow across laboratory comparisons. To facilitate more widespread use of QST, the German Pain Society (DGSS) and the DFNS have initiated a certification procedure for QST quality standards. Therefore, structural, procedural criteria and outcome parameters were establishd and are hereby presented.
By maintaining high quality standards, the certification of QST is intended to contribute to a better understanding of the mechanisms behind neuropathic pain syndromes and thereby improve patient care as well as sensory assessment in clinical studies on the treatment of neuropathic pain syndromes.
Literatur
Agostinho CM, Scherens A, Richter H et al (2008) Habituation and short-term repeatability of thermal testing in healthy human subjects and patients with chronic non-neuropathic pain. Eur J Pain [epub ahead of print]
Chong PS, Cros DP (2004) Technology literature review: quantitative sensory testing. Muscle Nerve 29:734–747
Cruccu G, Aminoff MJ, Curio G et al (2008) Recommendations for the clinical use of somatosensory-evoked potentials. Clin Neurophysiol 119:1705–1719
Cruccu G, Truini A (2006) Assessment of neuropathic pain. Neurol Sci 27:S288–S290
Eberle T, Doganci B, Krämer H et al (2008) Warm and cold complex regional pain syndromes (CRPS) – differences beyond skin temperature? Neurology, accepted for publication
Freeman R, Chase KP, Risk MR (2003) Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy. Neurology 60:465–470
Freynhagen R, Rolke R, Baron R et al (2007) Pseudoradicular and radicular low-back pain – a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 135(1–2):65–74
Geber C, Klein T, Rolke R et al (2007) Test/retest and interobserver-reliability in quantitative sensory testing according to the protocol on the German network on neuropathic pain (DFNS). Eur J Pain 11:S87
Hansson P (2002) Neuropathic pain: clinical characteristics and diagnostic workup. Eur J Pain 6 [suppl A):47–50
Huge V, Lauchart M, Forderreuther S et al (2008) Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I). PLoS ONE 3:e2742
Jensen TS, Baron R (2003) Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 102:1–8
Kowalski T, Maier C, Reinacher-Schick A et al (2008) Painful hyperexcitability syndrome with oxaliplatin containing chemotherapy. Clinical features, pathophysiology and therapeutic options. Schmerz 22:16–23
Lang PM, Schober GM, Rolke R et al (2006) Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease. Pain 124:190–200
Maag R, Binder A, Maier C et al (2008) Detection of a characteristic painful neuropathy in Fabry disease: a pilot study. Pain Med 9(8):1217–1223
Pavlakovic G, Klinke I, Pavlakovic H et al (2008) Effect of thermode application pressure on thermal threshold detection. Muscle Nerve 38:1498–1505
Peters EW, Bienfait HM, De Visser M et al (2003) The reliability of assessment of vibration sense. Acta Neurol Scand 107:293–298
Rolke R, Baron R, Maier C et al (2006) Quantitative sensory testing in the German research network on neuropathic pain (DFNS): standardized protocol and reference values. Pain 123:231–243
Rolke R, Magerl W, Campbell KA et al (2006) Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10:77–88
Scherens A, Maier C, Haussleiter IS et al (2008) Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: comparison of different diagnostic modalities. Eur J Pain, Sep 11 [epub ahead of print]
Shy ME, Frohman EM, So YT et al (2003) Quantitative sensory testing: report of the therapeutics and technology assessment subcommittee of the American academy of neurology. Neurology 60:898–904
Truini A, Cruccu G (2006) Pathophysiological mechanisms of neuropathic pain. Neurol Sci 27 [suppl 2]:S179–S182
Wasner GI, Brock JA (2008) Determinants of thermal pain thresholds in normal subjects. Clin Neurophysiol 119:2389–2395
Woolf CJ, Mannion RJ (1999) Neuropathic pain: etiology, symptoms, mechanisms, and management. Lancet 353:1959–1964
Yarnitsky D (1997) Quantitative sensory testing. Muscle Nerve 20:198–204
Yarnitsky D, Sprecher E, Zaslansky R et al (1995) Heat pain thresholds: normative data and repeatability. Pain 60:329–332
Interessenkonflikt
Die korrespondierende Autorin gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Additional information
Die Autoren C. Geber und A. Scherens haben den gleichen Anteil zur Manuskripterstellung beigetragen.
Rights and permissions
About this article
Cite this article
Geber, C., Scherens, A., Pfau, D. et al. Zertifizierungsrichtlinien für QST-Labore. Schmerz 23, 65–69 (2009). https://doi.org/10.1007/s00482-008-0771-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00482-008-0771-4