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Strontium oral load test in children with idiopathic hypercalciuria

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Abstract

Increased intestinal calcium absorption may play an important role in the pathogenesis of idiopathic hypercalciuria in children. Calcium absorption was assessed by an oral strontium load test in 22 prepubertal children (13 male) with idiopathic hypercalciuria, urinary calcium excretion 6.48 ± 0.60 mg/kg per day (range 4.12–13.40 mg/kg per day), and ten healthy, young, normocalciuric controls (six male). After administration of 2.65 mg/kg of strontium chloride (SrCl2), the serum concentrations of strontium at 30 min, 60 min, 120 min, 240 min, and the fraction of the absorbed dose (FAD%) at 30 min, 60 min and 240 min, were similar in both groups. FAD% at 120 min was lower (P < 0.05) in hypercalciuric children than in controls (11.84 ± 0.96% vs 15.87 ± 1.77%). Values of the area under the curve were not different between both groups. In children with idiopathic hypercalciuria, serum basal intact parathyroid hormone (PTH) (r = −0.59, P = 0.004) and the 1,25-dihydroxyvitamin D/PTH ratio (r = 0.65; P = 0.001) were correlated with the serum concentration of strontium at 60 min. The study reported here provides, for the first time, the results of a strontium oral load test in children with idiopathic hypercalciuria. With this method no major alterations of intestinal calcium absorption were found in this disorder.

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Acknowledgments

This work was partly supported by grant FIS 00/0537 from the Fondo de Investigaciones Sanitarias, Spanish Ministry of Health and the Fundación Nutrición y Crecimiento.

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Authors and Affiliations

  1. Hospital Carmen y Severo Ochoa, Cangas del Narcea, Spain

    Porfirio Fernández

  2. Hospital Universitario Central de Asturias, Oviedo, Spain

    Fernando Santos, Pilar Sotorrío & Juan Mayordomo

  3. Universidad de Oviedo, Oviedo, Spain

    Fernando Santos

  4. Instituto Universitario de Oncología, Oviedo, Spain

    Fernando Santos

  5. Hospital de León, León, Spain

    Luis Ferrero

  6. Pediatría, Facultad de Medicina, Julián Clavería 6, 33006, Oviedo, Spain

    Fernando Santos

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  1. Porfirio Fernández
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  2. Fernando Santos
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  3. Pilar Sotorrío
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  4. Juan Mayordomo
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  5. Luis Ferrero
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Correspondence to Fernando Santos.

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Fernández, P., Santos, F., Sotorrío, P. et al. Strontium oral load test in children with idiopathic hypercalciuria. Pediatr Nephrol 22, 1303–1307 (2007). https://doi.org/10.1007/s00467-007-0530-2

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  • DOI: https://doi.org/10.1007/s00467-007-0530-2

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