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The prognostic factor for outcome following second resection for intrahepatic recurrence of hepatocellular carcinoma with a hepatitis B virus infection background

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Abstract

Purpose

Second resection has been proved to be a safe and effective treatment for patients with intrahepatic recurrent HCC after primary resection; however, preoperative prognostic factors for outcome following second resection in patients with a hepatitis B virus (HBV) infection background remains to be clarified.

Methods

Fifty-seven patients with intrahepatic recurrent an HCC and HBV infection background received second resection from 1997 to 2003 in our institute. All of them were negative for anti-hepatitis C virus (HCV) and positive regarding HBV profile. Patient and tumor factors were analyzed.

Results

At the time of preparing this paper, 31 had re-recurrence and 21patients had died. No postoperative mortality was noted. The 1-, 3-, and 5-year overall survival after second resection were 69.9%, 61.2%, and 30.6%, respectively. Univariate and multivariate analysis showed that vascular invasion and time to recurrence were the independent prognostic factors for overall survival following second resection. The 3- and 4-year overall survival after second resection were 57.7% and 46.6% in patients with the presence of any of two risk factors (n=46), and 100% and 100% in those with absence of both risk factors (n=11, P=0.008).

Conclusions

Vascular invasion and time to recurrence were the prognostic factors for overall survival following second resection of intrahepatic recurrent HCC.

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Acknowledgments

The authors thank Qi-Wei Xu, Jiu-Qiao Zhou, Lu Lu, and Xue-Bin Qian for data collection

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Authors and Affiliations

  1. Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 200032, Shanghai, P.R. China

    Hui-Chuan Sun, Zhao-You Tang, Zeng-Chen Ma, Lun-Xiu Qin, Lu Wang, Qin-Hai Ye, Jia Fan, Zhi-Quan Wu & Xin-Da Zhou

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  1. Hui-Chuan Sun
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  2. Zhao-You Tang
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  3. Zeng-Chen Ma
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  4. Lun-Xiu Qin
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  5. Lu Wang
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  7. Jia Fan
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  8. Zhi-Quan Wu
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  9. Xin-Da Zhou
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Corresponding author

Correspondence to Zhao-You Tang.

Additional information

This study was jointly supported by a grant from the Shanghai Medical Center Project, the Promising Young Doctor of Shanghai grant from the Bureau of Public Health of Shanghai, and the Project 211 grant from Ministry of Education of China.

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Sun, HC., Tang, ZY., Ma, ZC. et al. The prognostic factor for outcome following second resection for intrahepatic recurrence of hepatocellular carcinoma with a hepatitis B virus infection background. J Cancer Res Clin Oncol 131, 284–288 (2005). https://doi.org/10.1007/s00432-004-0645-9

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  • DOI: https://doi.org/10.1007/s00432-004-0645-9

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