Abstract
Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic infiltrate. The immunoprofile of the tumor showed negativity for cytokeratins and led to the diagnosis of a CD30-positive anaplastic large cell lymphoma.
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Arber DA, Simpson JF, Weiss LM, Rappaport H (1994) Non-Hodgkin’s lymphoma involving the breast. Am J Surg Pathol 18:288–295
Ariad S, Lewis D, Cohen R, Bezwoda WR (1995) Breast lymphoma. A clinical and pathological review and 10-year treatment results. S Afr Med J 85:85–89
Brinton LA, Brown SL (1997) Breast implants and cancer. J Natl Cancer Inst 89:1341–1349
Cook PD, Osborne BM, Connor RL, Strauss JF (1995) Follicular lymphoma adjacent to foreign body granulomatous inflammation and fibrosis surrounding silicone breast prosthesis. Am J Surg Pathol 19:712–717
Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP (2002) Lymphomas of the breast: primary and secondary involvement. Cancer 94:6–13
Duvic M, Moore D, Menter A, Vonderheid EC (1995) Cutaneous T-cell lymphoma in association with silicone breast implants. J Am Acad Dermatol 32:939–942
Gaudet G, Friedberg JW, Weng A, Pinkus GS, Freedman AS (2002) Breast lymphoma associated with breast implants: two case-reports and a review of the literature. Leuk Lymphoma 43:115–119
Grubstein A, Givon-Madhala O, Morgenstern S, Cohen M (2005) Extranodal primary B-cell non-Hodgkin lymphoma of the breast mimicking acute mastitis. J Clin Ultrasound 33:140–142
Hakoda Y, Gotoh A, Kuriyama Y, Kusama M, Koyanagi Y, Serizawa H, Mukai K, Ohyashiki K (2001) Breast MALT lymphoma: potential relationship between hormonal environment and female sex hormone receptor expression in lymphoma cells. Leuk Lymphoma 42:1157–1159
Jaffe ES, Harris NL, Stein H, Vardiman JW (2006) World Health Organization classification of tumours. Pathology & genetics: tumours of the haematopathologic and lymphoid tissue. IARC Press, Lyon
Keech JA Jr, Creech BJ (1997) Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg 100:554–555
Kraemer DM, Tony HP, Gattenlohner S, Muller JG (2003) Lymphoplasmacytic lymphoma in a patient with leaking silicone implant. Haematologica 88:ELT30
Kraemer DM, Weissinger F, Reimer P, Kunzmann V, Rudiger T, Wilhelm M (2003) Female patient with a history of Hashimoto’s thyroiditis, diagnosed with MALT lymphoma of both breasts. Onkologie 26:277–280
Lin Y, Govindan R, Hess JL (1997) Malignant hematopoietic breast tumors. Am J Clin Pathol 107:177–186
Liu MT, Hsieh CY, Wang AY, Pi CP, Chang TH, Huang CC, Huang CY (2005) Primary breast lymphoma: a pooled analysis of prognostic factors and survival in 93 cases. Ann Saudi Med 25:288–293
Loughrey MB, Windrum P, Catherwood MA, Alexander HD, Markey GM, McManus DT, Morris TC (2004) WHO reclassification of breast lymphomas. J Clin Pathol 57:1213–1214
Ryan GF, Roos DR, Seymour JF (2006) Primary non-Hodgkin’s lymphoma of the breast: retrospective analysis of prognosis and patterns of failure in two Australian centers. Clin Lymphoma Myeloma 6:337–341
Sahoo S, Rosen PP, Feddersen RM, Viswanatha DS, Clark DA, Chadburn A (2003) Anaplastic large cell lymphoma arising in a silicone breast implant capsule: a case report and review of the literature. Arch Pathol Lab Med 127:e115–e118
Said JW, Tasaka T, Takeuchi S, Asou H, de Vos S, Cesarman E, Knowles DM, Koeffler HP (1996) Primary effusion lymphoma in women: report of two cases of Kaposi’s sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women. Blood 88:3124–3128
Tan PH, Sng IT (1996) Breast lymphoma—a pathologic study of 14 cases. Ann Acad Med Singap 25:783–790
Topalovski M, Crisan D, Mattson JC (1999) Lymphoma of the breast. A clinicopathologic study of primary and secondary cases. Arch Pathol Lab Med 123:1208–1218
Venizelos ID, Tatsiou ZA, Vakalopoulou S, Mandala E, Garipidou V (2005) Primary non-Hodgkin’s lymphoma arising in an intramammary lymph node. Leuk Lymphoma 46:451–455
Vigliotti ML, Dell’olio M, La Sala A, Di Renzo N (2005) Primary breast lymphoma: outcome of 7 patients and a review of the literature. Leuk Lymphoma 46:1321–1327
Vignot S, Ledoussal V, Nodiot P, Bourguignat A, Janvier M, Mounier N, Cherel P, Floiras JL, Turpin F (2005) Non-Hodgkin’s lymphoma of the breast: a report of 19 cases and a review of the literature. Clin Lymphoma 6:37–42
Wiseman C, Liao KT (1972) Primary lymphoma of the breast. Cancer 29:1705–1712
Young JL Jr, Ward KC, Wingo PA, Howe HL (2004) The incidence of malignant non-carcinomas of the female breast. Cancer Causes Control 15:313–319
Zobolas B, Sakorafas GH, Kourakli I, Tsiotou AG (2002) Bilateral, primary, low-grade, diffuse B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) of the breast. Breast J 8:382
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Fritzsche, F.R., Pahl, S., Petersen, I. et al. Anaplastic large-cell non-Hodgkin’s lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer—a case report. Virchows Arch 449, 561–564 (2006). https://doi.org/10.1007/s00428-006-0287-1
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DOI: https://doi.org/10.1007/s00428-006-0287-1