Abstract
Medical records of 158 patients with bipolar depression were analysed for the incidence of a switch from depression to maniform states (mania and hypomania). Relation to psychopharmacological treatment was investigated. Thirty-nine (25%) patients of the total sample had switched to a maniform state during the treatment period in the hospital. Among that group the phenomenon occurred in 23 patients (15%) as a hypomania and in 16 patients (10%) as a mania. Patients with a switch were significantly more often treated with tricyclic antidepressants (TCA) than patients without switch (79.5% vs 51.3%). Mood stabilising medication might reduce the risk for switching, especially in patients treated with TCA; however, it seems not totally sufficient, since 59% of the switched patients received mood stabilisers. The switch phenomenon was not associated with sociodemographic or clinical data.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 23 September 1998 / Accepted: 28 September 1998
Rights and permissions
About this article
Cite this article
Bottlender, R., Rudolf, D., Strauss, A. et al. Antidepressant-associated maniform states in acute treatment of patients with bipolar-I depression. European Archives of Psychiatry and Clinical Neurosciences 248, 296–300 (1998). https://doi.org/10.1007/s004060050053
Issue Date:
DOI: https://doi.org/10.1007/s004060050053