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High field magnetic resonance imaging of rodents in cardiovascular research

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An Erratum to this article was published on 04 August 2016

Abstract

Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7–11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.

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Fig. 1
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Reproduced with permission from Jacoby et al. [70]

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Reproduced with permission from Flögel et al. [51]

Fig. 8

Reproduced with permission from Büscher et al. [31]

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Abbreviations

ASL:

Arterial spin labeling

CEST:

Chemical exchange saturation transfer

CS:

Compressed sensing

CT:

Computed tomography

DENSE:

Displacement encoding with stimulated echoes

FLASH:

Fast low angle shot

FPP:

First pass perfusion

IR:

Inversion recovery

LGE:

Late gadolinium enhancement

MBF:

Myocardial blood flow

MEMRI:

Manganese-enhance magnetic resonance imaging

MRA:

Magnetic resonance angiography

MRS:

Magnetic resonance spectroscopy

MRSI:

Magnetic resonance spectroscopic imaging

PET:

Positron emission tomography

PC:

Phase contrast

RF:

Radiofrequency

SNR:

Signal-to-noise ratio

SPIONs:

Superparamagnetic iron oxide nanoparticles

TOF:

Time of flight

HF:

High field

Venc:

Velocity encoding

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Acknowledgments

The authors thank Hassan Jassar and Nicolas Joudiou for assistance during MRI manipulations. This work was supported by Grants from the Fonds de la Recherche Scientifique FRS-FNRS, the Foundation Saint-Luc and the Belgian National Foundation for Research in Pediatric Cardiology.

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Authors and Affiliations

  1. Department of Paediatric Cardiology, Cliniques universitaires Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium

    Laetitia Vanhoutte & Stéphane Moniotte

  2. Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium

    Laetitia Vanhoutte, Balligand Jean-Luc & Olivier Feron

  3. Division of Cardiology, Cliniques universitaires Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium

    Bernhard L. Gerber

  4. Pole of Cardiovascular Research (CARD), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium

    Bernhard L. Gerber

  5. Biomedical Magnetic Resonance Unit (REMA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain (UCL), Brussels, Belgium

    Bernard Gallez

  6. CNRS, ICube, FMTS, Institut de Physique Biologique, Faculté de Médecine, Université de Strasbourg, Strasbourg, France

    Chrystelle Po

  7. L’Institut de RYthmologie et de Modélisation Cardiaque (LIRYC), Inserm U1045, Bordeaux, France

    Julie Magat

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  1. Laetitia Vanhoutte
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Correspondence to Laetitia Vanhoutte.

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All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees. No human studies were carried out by the authors for this article.

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Vanhoutte, L., Gerber, B.L., Gallez, B. et al. High field magnetic resonance imaging of rodents in cardiovascular research. Basic Res Cardiol 111, 46 (2016). https://doi.org/10.1007/s00395-016-0565-2

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