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Verfügbare Lasersysteme und Wirkprinzip der Lasertrabekuloplastik

Available laser systems and mechanism of action in laser trabeculoplasty

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Zusammenfassung

Augeninnendrucksenkende Laserverfahren wie die Argonlasertrabekuloplastik oder die selektive Lasertrabekuloplastik sind aus der heutigen Glaukomtherapie nicht mehr wegzudenken. Dargestellt werden die derzeit gängisten Lasersysteme. Sie unterscheiden sich durch den physikalisch voneinander abweichenden Aufbau der Laser sowie durch die unterschiedliche Erzeugung des Laserlichts. Sie differieren sowohl in ihrem Effekt auf den Kammerwinkel auf histopathologischer Ebene als auch in den Wirkprinzipien der Augeninnendrucksenkung. Aktuell dienen die mechanische, die biologische und die Repopulationstheorie zur Erklärung der augeninnendrucksenkenden Wirkung der unterschiedlichen Lasersysteme. Sie werden in diesem Beitrag detailliert dargestellt.

Abstract

Intraocular pressure-lowering laser procedures such as argon laser trabeculoplasty and selective laser trabeculoplasty are nowadays an essential part of glaucoma therapy. This article presents the currently most popular laser systems. These various laser procedures are based on the physical structure of the different lasers and on variable generation of laser light. They vary in their effect on the trabecular meshwork on a histopathological level, as well as in the active principles of intraocular pressure reduction. The mechanical, biological, and repopulation theories are currently used to explain the intraocular pressure-lowering effect of the different laser systems; these are discussed in detail.

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Literatur

  1. Acott TS, Samples JR, Bradley JM et al (1989) Trabecular repopulation by anterior trabecular meshwork cells after laser trabeculoplasty. Am J Ophthalmol 107:1–6

    CAS  PubMed  Google Scholar 

  2. Best UP, Domack H, Schmidt V (2007) Pressure reduction after selective laser trabeculoplasty with two different laser systems and after argon laser trabeculoplasty-a controlled prospective clinical trial on 284 eyes. Klin Monatsbl Augenheilkd 224:173–179

    Article  PubMed  Google Scholar 

  3. Bradley JM, Anderssohn AM, Colvis CM et al (2000) Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1beta and TNFalpha. Invest Ophthalmol Vis Sci 41:422–430

    CAS  PubMed  Google Scholar 

  4. Bylsma SS, Samples JR, Acott TS, Van Buskirk EM (1988) Trabecular cell division after argon laser trabeculoplasty. Arch Ophthalmol 106:544–547

    CAS  PubMed  Google Scholar 

  5. Cvenkel B, Hvala A, Drnovsek-Olup B, Gale N (2003) Acute ultrastructural changes of the trabecular meshwork after selective laser trabeculoplasty and low power argon laser trabeculoplasty. Lasers Surg Med 33:204–208

    Article  PubMed  Google Scholar 

  6. de Kater AW, Melamed S, Epstein DL (1989) Patterns of aqueous humor outflow in glaucomatous and nonglaucomatous human eyes. A tracer study using cationized ferritin. Arch Ophthalmol 107:572–576

    Google Scholar 

  7. Detry-Morel M, Muschart F, Pourjavan S (2008) Micropulse diode laser (810 nm) versus argon laser trabeculoplasty in the treatment of open-angle glaucoma: comparative short-term safety and efficacy profile. Bull Soc Belge Ophtalmol 21–28

  8. Dueker DK, Norberg M, Johnson DH et al (1990) Stimulation of cell division by argon and Nd:YAG laser trabeculoplasty in cynomolgus monkeys. Invest Ophthalmol Vis Sci 31:115–124

    CAS  PubMed  Google Scholar 

  9. Fink AI, Jordan AJ, Lao PN, Fong DA (1988) Therapeutic limitations of argon laser trabeculoplasty. Br J Ophthalmol 72:263–269

    Article  CAS  PubMed  Google Scholar 

  10. Hollo G (1996) Argon and low energy, pulsed Nd:YAG laser trabeculoplasty. A prospective, comparative clinical and morphological study. Acta Ophthalmol Scand 74:126–131

    Article  CAS  PubMed  Google Scholar 

  11. Johnson DH (2007) Histologic findings after argon laser trabeculoplasty in glaucomatous eyes. Exp Eye Res 85:557–562. Epub 2007 Jul 20

    Article  CAS  PubMed  Google Scholar 

  12. Kramer TR, Noecker RJ (2001) Comparison of the morphologic changes after selective laser trabeculoplasty and argon laser trabeculoplasty in human eye bank eyes. Ophthalmology 108:773–779

    Article  CAS  PubMed  Google Scholar 

  13. Latina MA, de Leon JM (2005) Selective laser trabeculoplasty. Ophthalmol Clin North Am 18:409–419, vi

    Article  PubMed  Google Scholar 

  14. McHugh D, Marshall J, Ffytche TJ et al (1992) Ultrastructural changes of human trabecular meshwork after photocoagulation with a diode laser. Invest Ophthalmol Vis Sci 33:2664–2671

    CAS  PubMed  Google Scholar 

  15. McMillan TA, Stewart WC, Legler UF et al (1994) Comparison of diode and argon laser trabeculoplasty in cadaver eyes. Invest Ophthalmol Vis Sci 35:706–710

    CAS  PubMed  Google Scholar 

  16. Melamed S, Pei J, Epstein DL (1985) Short-term effect of argon laser trabeculoplasty in monkeys. Arch Ophthalmol 103:1546–1552

    CAS  PubMed  Google Scholar 

  17. Melamed (1997) Argon laser trabeculoplasty: how does it work? Williams and Wilkins, Baltimore

  18. Rüdiger P (2004) Encyclopedia of laser physics and technology. WILEY-VCH

  19. Stein JD, Challa P (2007) Mechanisms of action and efficacy of argon laser trabeculoplasty and selective laser trabeculoplasty. Curr Opin Ophthalmol 18:140–145

    Article  PubMed  Google Scholar 

  20. Van Buskirk EM, Pond V, Rosenquist RC, Acott TS (1984) Argon laser trabeculoplasty. Studies of mechanism of action. Ophthalmology 91:1005–1010

    Google Scholar 

  21. Worthen DM, Wickham MG (1973) Laser trabeculotomy in monkeys. Invest Ophthalmol Vis Sci 12:707–711

    CAS  Google Scholar 

  22. Krasnov MM (1977) Q-switched laser iridectomy and Q-switched laser goniopuncture. Adv Ophthalmol 34:192–196

    CAS  PubMed  Google Scholar 

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Kuerzinger, G., Eckert, S. Verfügbare Lasersysteme und Wirkprinzip der Lasertrabekuloplastik. Ophthalmologe 107, 8–12 (2010). https://doi.org/10.1007/s00347-009-2051-9

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