Abstract
Introduction
Tubulocystic renal carcinoma (TCRC) is a recently described neoplastic entity. To date, clinicopathological features on less than hundred cases of these rare tumours have been characterized exclusively in the pathological literature. Herein, we present five additional cases emphasizing clinical aspects on these rare renal neoplasms.
Material and method
Cases diagnosed as TCRC were retrieved and reviewed from the routine and consultation files of the Pilsen tumour registry comprising over 20,000 cases of renal tumours.
Results
All patients were men, mean age 56 years (range 29–70). Features on computed tomography (CT) were in two cases Bosniak III, one IV and two were solid tumours. In four patients, nephrectomy was performed, and one patient underwent resection. At the time of surgery, two patients had metastases. In one case, both primary tumour and metastases were active on FDG positron emission tomography (PET)/CT. Both patients with metastatic disease were treated with sunitinib with partial response. One patient died 26 months postoperatively and the other patient is alive 5 months after surgery. Three patients with localized tumours are without evidence of disease 31, 28 and 7 months after surgery. In one case, the resected tumour was histologically combined with a papillary renal cell carcinoma (PRCC).
Conclusion
TCRC occurs predominantly in men with a wide age range. TCRC frequently displays a cystic component which may render a radiological classification of Bosniak III or IV. FDG PET/CT is helpful in the detection of metastases. TCRC has definitive malignant potential. Our findings support a possible relationship to PRCC. The tyrosine kinase inhibitor sunitinib may be used a therapeutical agent with partial response and temporary effect.
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References
Delahunt B, Amin MB, Hofstadter F et al (2004) Tumors of the renal pelvis and the ureter. In: Eble J, Sauter G, Epstein J (eds) World Health Organisation classification of tumors: tumors of the urinary system and male genital organs. IARC press, Lyon, pp 150–153
Murphy W, Grignon D, Perlman E (2004) Tumors of the ureters and the renal pelvis. AFIP atlas of tumor pathology: tumors of the kidney, bladder and related urinary structures. American Registry of Pathology, Washington, pp 375–382
Masson P (1970) Tumeurs humaines 1955. Human tumors, histology, diagnosis and technique. Wayne State University Press, Detroit
MacLennan GT, Farrow GM, Bostwick DG (1997) Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology 50(5):679–684
Hes O, Hora M, Perez-Montiel DM, Suster S, Curík R, Sokol L, Ondic O, Mikulástík J, Betlach J, Peychl L, Hrabal P, Kodet R, Straka L, Ferák I, Vrabec V, Michal M (2002) Spindle cuboidal renal cell carcinoma, a tumour having frequent association with nephrolithiasis: report of 11 cases including a case with hybrid conventional renal cell carcinoma/spindle, cuboidal renal cell carcinoma components. Histopathology 41(6):549–555
MacLennan GT, Bostwick DG (2005) Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors. Clin Lab Med 25:393–416
Yang XJ, Zhou M, Hes O, Shen S, Li R, Lopez J, Shah RB, Yang Y, Chuang ST, Lin F, Tretiakova MM, Kort EJ, Teh BT (2008) Tubulocystic carcinoma of the kidney: clinicopathologic, molecular characterization. Am J Surg Pathol 32(2):177–187
Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, Paner GP, Stovsky M, Young AN, Srigley JR, Cheville JC (2009) Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol 33(3):384–392
Amin MB, MacLennan GT, Paraf F, et al. (2004) Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 29 cases of a distinctive rare subtype of renal carcinoma. Mod Pathol 28(suppl):137A
Azoulay S, Vieillefond A, Paraf F, Pasquier D, Cussenot O, Callard P, Sibony M (2007) Tubulocystic carcinoma of the kidney: a new entity among renal tumors. Virchows Arch 451(5):905–909
Zhou M, Yang XJ, Lopez JI, Shah RB, Hes O, Shen SS, Li R, Yang Y, Lin F, Elson P, Sercia L, Magi-Galluzzi C, Tubbs R (2009) Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. Am J Surg Pathol 33(12):1840–1849
San Miguel Fraile P, Dos Santos JE, Delgado C, Zungri Telo E, Alvarez C, Iglesias B (2004) Low grade collecting duct carcinoma of the kidney. Presentation of one case and literature revision. Actas Urol Esp 28(6):478–483
Gönül II, Cakr A, Sözen S, Ataoglu O, Alkibay T (2009) A case of tubulocystic carcinoma simultaneously occurring with clear cell type renal cell carcinoma, micropapillary urothelial carcinoma of bladder. South Med J 102(7):754–757
Moses KA, Decaro JJ, Osunkoya AO, Issa MM (2010) Tubulocystic carcinoma of the kidney: a case report of natural history and long-term follow-up. Sci World J 10:586–589
Osunkoya AO, Young AN, Wang W, Netto GJ, Epstein JI (2009) Comparison of gene expression profiles in tubulocystic carcinoma, collecting duct carcinoma of the kidney. Am J Surg Pathol 33(7):1103–1106
Brennan C, Srigley JR, Whelan C, Cooper J, Delahunt B (2010) Type 2 and clear cell papillary renal cell carcinoma, and tubulocystic carcinoma: a unifying concept. Anticancer Res 30:641–644
Mego M, Sycova-Mila Z, Rejlekova K, Rychly B, Obertova J, Rajec J, Hes O, Mardiak J (2008) Sunitinib in the treatment of tubulocystic carcinoma of the kidney. A case report. Ann Oncol 19(9):1655–1656
Israel GM, Bosniak MA (2005) An update of the Bosniak renal cyst classification system. Urology 66:484–488
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228–247
Srigley JR, Delahunt B (2009) Uncommon and recently described renal carcinomas. Mod Pathol 22(Suppl 2):S2–S23
Moch H (2010) Cystic renal tumors: new entities, novel concepts. Adv Anat Pathol 17(3):209–214
Hora M, Hes O, Michal M, Boudová L, Chudáček Z, Kreuzberg B, Klečka J (2005) Extensively cystic renal neoplasms in adults (Bosniak classification II or III)—Possible “common” histological diagnoses: multilocular cystic renal cell carcinoma, cystic nephroma, and mixed epithelial and stromal tumor of the kidney. Int Urol Nephrol 37(4):743–750
Hora M, Michal M, Hes Rodolfo O, M RE, Mazzuccelli R, Lopez-Beltran A et al (2009) Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? Eur Urol 56(1):e3
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The work was supported by the Czech government research project MSM 0021620819.
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The authors declare that they have no conflict of interest.
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Hora, M., Ürge, T., Eret, V. et al. Tubulocystic renal carcinoma: a clinical perspective. World J Urol 29, 349–354 (2011). https://doi.org/10.1007/s00345-010-0614-7
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DOI: https://doi.org/10.1007/s00345-010-0614-7