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Prognostic factors of Chinese patients with primary pulmonary non-Hodgkin’s lymphoma: the single-institute experience in Taiwan

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Abstract

Primary pulmonary lymphoma (PPL) accounts for less than 1% of patients with non-Hodgkin’s lymphoma, with no report in Chinese patients. This study aims to analyze the clinical features and prognosis of this population. Patients with biopsy-proven pulmonary lymphoma were reviewed and re-classified by a hema-pathologist. Between 1992 and 2005, a total of 22 patients were identified (16 men and six women), with a mean age of 70 years. The histological subtypes included marginal zone B-cell lymphoma of mucosa-associated lymphoid tissues (MALT) in 12 patients (54%), diffuse large B-cell lymphoma in nine (41%), and one case of lymphomatoid granulomatosis. Diseases mainly manifested as pulmonary nodules or masses in 73% of patients, with a higher rate of hilar/mediastinal lymphadenopathy in non-MALT patients (8% vs. 80%, P = 0.002). In eight patients (36% of 22), diagnoses were only conclusive until the biopsy via thoracotomy. Eighteen patients (82%) received chemotherapy. The 5-year rates of overall survival (OS) were 91% and 21% for MALT and non-MALT types of PPL, respectively. Patients who had received surgical resection tended to have a better 5-year OS rate (P = 0.077). The Cox-regression analysis showed that two factors—elevated serum lactate dehydrogenase level and hilar/mediastinal lymphadenopathy at diagnosis—were independently associated with a poor OS, with a hazard ratio of 10.370 and 5.171 (P = 0.01 and 0.033), respectively. In conclusion, the histological subtypes of Chinese PPL patients were similar to those in previous reports, with no increasing incidence of T-cell immunophenotype. The two prognostic factors provided additional information in managing these patients.

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References

  1. Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260. doi:10.1002/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#

    Article  PubMed  CAS  Google Scholar 

  2. L’Hoste RJ Jr, Filippa DA, Lieberman PH, Bretsky S (1984) Primary pulmonary lymphomas. A clinicopathologic analysis of 36 cases. Cancer 54:1397–1406. doi:10.1002/1097-0142(19841001)54:7<1397::AID-CNCR2820540728>3.0.CO;2-4

    Article  PubMed  Google Scholar 

  3. Clagett OT, Allen TH, Payne WS, Woolner LB (1964) The surgical treatment of pulmonary neoplasms: a 10-year experience. J Thorac Cardiovasc Surg 48:391–400

    PubMed  CAS  Google Scholar 

  4. Ferraro P, Trastek VF, Adlakha H, Deschamps C, Allen MS, Pairolero PC (2000) Primary non-Hodgkin’s lymphoma of the lung. Ann Thorac Surg 69:993–997. doi:10.1016/S0003-4975(99)01535-0

    Article  PubMed  CAS  Google Scholar 

  5. Kurtin PJ, Myers JL, Adlakha H, Strickler JG, Lohse C, Pankratz VS, Inwards DJ (2001) Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. Am J Surg Pathol 25:997–1008. doi:10.1097/00000478-200108000-00003

    Article  PubMed  CAS  Google Scholar 

  6. Cordier JF, Chailleux E, Lauque D, Reynaud-Gaubert M, etemann-Molard A, Dalphin JC, Blanc-Jouvan F, Loire R (1993) Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients. Chest 103:201–208. doi:10.1378/chest.103.1.201

    Article  PubMed  CAS  Google Scholar 

  7. Tamura A, Komatsu H, Yanai N, Homma J, Nagase A, Nemoto E, Hirai T, Hashizume T, Kawata K, Ishikawa S (1995) Primary pulmonary lymphoma: relationship between clinical features and pathologic findings in 24 cases. The Japan National Chest Hospital Study Group for Lung Cancer. Jpn J Clin Oncol 25:140–152

    PubMed  CAS  Google Scholar 

  8. Zinzani PL, Tani M, Gabriele A, Poletti V, Stefoni V, Alinari L, Musuraca G, Bonifazi F, Pileri S, Tura S, Baccarani M (2003) Extranodal marginal zone B-cell lymphoma of MALT-type of the lung: single-center experience with 12 patients. Leuk Lymphoma 44:821–824. doi:10.1080/1042819031000067972

    Article  PubMed  CAS  Google Scholar 

  9. Ahmed S, Kussick SJ, Siddiqui AK, Bhuiya TA, Khan A, Sarewitz S, Steinberg H, Sison CP, Rai KR (2004) Bronchial-associated lymphoid tissue lymphoma: a clinical study of a rare disease. Eur J Cancer 40:1320–1326. doi:10.1016/j.ejca.2004.02.006

    Article  PubMed  Google Scholar 

  10. Kim JH, Lee SH, Park J, Kim HY, Lee SI, Park JO, Kim K, Kim WS, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Park K, Han JH, Ko YH (2004) Primary pulmonary non-Hodgkin’s lymphoma. Jpn J Clin Oncol 34:510–514. doi:10.1093/jjco/hyh095

    Article  PubMed  Google Scholar 

  11. The Non-Hodgkin’s Lymphoma Pathologic Classification Project (1982) National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas: summary and description of a working formulation for clinical usage. Cancer 49:2112–2135. doi:10.1002/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2

    Article  Google Scholar 

  12. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008) WHO classification of tumours of haematopoietic and lymphoid tissues,, 4th edn. International Agency for Research on Cancer, Lyon, France

    Google Scholar 

  13. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project (1993) A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 329:987–994. doi:10.1056/NEJM199309303291402

    Article  Google Scholar 

  14. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, Lister TA, Vose J, Grillo-Lopez A, Hagenbeek A, Cabanillas F, Klippensten D, Hiddemann W, Castellino R, Harris NL, Armitage JO, Carter W, Hoppe R, Canellos GP (1999) Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. NCI Sponsored International Working Group. J Clin Oncol 17:1244–1253

    PubMed  CAS  Google Scholar 

  15. Hu YH, Liu CY, Chiu CH, Hsiao LT (2007) Successful treatment of elderly advanced lymphomatoid granulomatosis with rituximab-CVP combination therapy. Eur J Haematol 78:176–177

    Article  PubMed  Google Scholar 

  16. Ray P, Antoine M, Mary-Krause M, Lebrette MG, Wislez M, Duvivier C, Meyohas MC, Girard PM, Mayaud C, Cadranel J (1998) AIDS-related primary pulmonary lymphoma. Am J Respir Crit Care Med 158:1221–1229

    PubMed  CAS  Google Scholar 

  17. Vanden Eynden F, Fadel E, de Perrot M, de Montpreville V, Mussot S, Dartevelle P (2007) Role of surgery in the treatment of primary pulmonary B-cell lymphoma. Ann Thorac Surg 83:236–240. doi:10.1016/j.athoracsur.2006.08.026

    Article  PubMed  Google Scholar 

  18. Wannesson L, Cavalli F, Zucca E (2005) Primary pulmonary lymphoma: current status. Clin Lymphoma Myeloma 6:220–227. doi:10.3816/CLM.2005.n.049

    Article  PubMed  CAS  Google Scholar 

  19. Lewis ER, Caskey CI, Fishman EK (1991) Lymphoma of the lung: CT findings in 31 patients. Am J Roentgenol 156:711–714

    CAS  Google Scholar 

  20. Zucca E, Conconi A, Pedrinis E, Cortelazzo S, Motta T, Gospodarowicz MK, Patterson BJ, Ferreri AJ, Ponzoni M, Devizzi L, Giardini R, Pinotti G, Capella C, Zinzani PL, Pileri S, Lopez-Guillermo A, Campo E, Ambrosetti A, Baldini L, Cavalli F (2003) Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Blood 101:2489–2495. doi:10.1182/blood-2002-04-1279

    Article  PubMed  CAS  Google Scholar 

  21. Bae YA, Lee KS, Han J, Ko YH, Kim BT, Chung MJ, Kim TS (2008) Marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: imaging findings in 21 patients. Chest 133:433–440. doi:10.1378/chest.07-1956

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Hematology & Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd, Taipei, 112, Taiwan

    Yu-Hui Hu, Liang-Tsai Hsiao, Jin-Hwang Liu, Jyh-Pyng Gau, Chueh-Chuan Yen, Po-Min Chen & Cheng-Hwai Tzeng

  2. National Yang-Ming University School of Medicine, Taipei, Taiwan

    Yu-Hui Hu, Liang-Tsai Hsiao, Ching-Fen Yang, Tzeon-Jye Chiou, Jin-Hwang Liu, Jyh-Pyng Gau, Chueh-Chuan Yen, Teh-Ying Chou, Wen-Hu Hsu, Po-Min Chen & Cheng-Hwai Tzeng

  3. Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan

    Ching-Fen Yang & Teh-Ying Chou

  4. Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Tzeon-Jye Chiou

  5. Division of Thoracic Surgery, Department of Surgery, Pathology, Taipei Veterans General Hospital, Taipei, Taiwan

    Wen-Hu Hsu

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  1. Yu-Hui Hu
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Correspondence to Liang-Tsai Hsiao.

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YHH and LTH have equal contribution.

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Hu, YH., Hsiao, LT., Yang, CF. et al. Prognostic factors of Chinese patients with primary pulmonary non-Hodgkin’s lymphoma: the single-institute experience in Taiwan. Ann Hematol 88, 839–846 (2009). https://doi.org/10.1007/s00277-008-0685-3

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  • DOI: https://doi.org/10.1007/s00277-008-0685-3

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