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Image-derived input functions for PET brain studies

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

To assess the robustness of a previously introduced method to obtain accurate image-derived input functions (IDIF) for three other tracers.

Methods

Dynamic PET and online blood data of five repeat [11C]PIB (Pittsburgh Compound-B) ([11C]PIB), six repeat (R)-[11C]verapamil, and ten single (R)-[11C]PK11195 studies were used. IDIFs were extracted from partial volume corrected scans using the four hottest pixels per plane method. Results obtained with IDIFs were compared with those using standard online measured arterial input functions (BSIF). IDIFs were used both with and without calibration based on manual blood samples.

Results

For (R)-[11C]verapamil, accurate IDIFs were obtained using noncalibrated IDIFs (slope 0.96±0.17; R 2 0.92±0.07). However, calibration was necessary to obtain IDIFs comparable to the BSIF for both [11C]PIB (slope 1.04±0.05; R 2 1.00±0.01) and (R)-[11C]PK11195 (slope 0.96±0.05; R 2 0.99±0.01). The need for calibration may be explained by the sticking property of both tracers, indicating that BSIF may be affected by sticking and therefore may be unreliable.

Conclusion

The present study shows that a previously proposed method to extract IDIFs is suitable for analysing [11C]PIB, (R)-[11C]verapamil and (R)-[11C]PK11195 studies, thereby obviating the need for online arterial sampling.

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Acknowledgements

This work was financially supported by the Netherlands Organisation for Scientific Research (NWO, VIDI Grant 016.066.309), the American Health Assistance Foundation (Grant A2005-026) and Internationale Stichting Alzheimer Research (Grant #05512). The authors would like to thank Floris H.P. van Velden for his useful comments and the PET radiochemistry and technology staff of the Division of Nuclear Medicine and PET Research for production of isotopes and acquisition of metabolites and PET data.

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Authors and Affiliations

  1. Department of Nuclear Medicine and PET Research, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands

    Jurgen E. M. Mourik, Mark Lubberink, Alie Schuitemaker, Nelleke Tolboom, Bart N. M. van Berckel, Adriaan A. Lammertsma & Ronald Boellaard

  2. Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands

    Alie Schuitemaker & Nelleke Tolboom

Authors
  1. Jurgen E. M. Mourik
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  2. Mark Lubberink
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  3. Alie Schuitemaker
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  4. Nelleke Tolboom
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  5. Bart N. M. van Berckel
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  6. Adriaan A. Lammertsma
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  7. Ronald Boellaard
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Corresponding author

Correspondence to Jurgen E. M. Mourik.

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Mourik, J.E.M., Lubberink, M., Schuitemaker, A. et al. Image-derived input functions for PET brain studies. Eur J Nucl Med Mol Imaging 36, 463–471 (2009). https://doi.org/10.1007/s00259-008-0986-8

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  • DOI: https://doi.org/10.1007/s00259-008-0986-8

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