References
Rumore MM (1984) Clinical pharmacokinetics of chlorpheniramine. Drug Intell Clin Pharm 18:701–707
Yasuda SU, Zannikos P, Young AE, Fried KM, Wainer IW, Woosley RL (2002) The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine. Br J Clin Pharmacol 53:519–525
Paton DM, Webster DR (1985) Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet 10:477–497
Huang SM, Athanikar NK, Sridhar K, Huang YC, Chiou WL (1982) Pharmacokinetics of chlorpheniramine after intravenous and oral administration in normal adults. Eur J Clin Pharmacol 22:359–365
Hong HK, Jo SH (2009) Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine. Korean J Physiol Pharmacol 13:215–220
Salata JJ, Jurkiewicz NK, Wallace AA, Stupienski RF 3rd, Guinosso PJ Jr, Lynch JJ Jr (1995) Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res 76:110–119
Taglialatela M, Castaldo P, Pannaccione A, Giorgio G, Genovese A, Marone G, Annunziato L (1999) Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity. Clin Exp Allergy 29(Suppl 3):182–189
Taglialatela M, Timmerman H, Annunziato L (2000) Cardiotoxic potential and CNS effects of first-generation antihistamines. Trends Pharmacol Sci 21:52–56
Wang WX, Ebert SN, Liu XK, Chen YW, Drici MD, Woosley RL (1998) “Conventional” antihistamines slow cardiac repolarization in isolated perfused (Langendorff) feline hearts. J Cardiovasc Pharmacol 32:123–128
Khalifa M, Drolet B, Daleau P, Lefez C, Gilbert M, Plante S, O'Hara GE, Gleeton O, Hamelin BA, Turgeon J (1999) Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramine. J Pharmacol Exp Ther 288:858–865
Chouinard G, Ghadirian AM, Jones BD (1978) Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule. Can Med Assoc J 119:729–731
Drolet B, Vincent F, Rail J, Chahine M, Deschenes D, Nadeau S, Khalifa M, Hamelin BA, Turgeon J (1999) Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current. J Pharmacol Exp Ther 288:1261–1268
Shin JG, Soukhova N, Flockhart DA (1999) Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos 27:1078–1084
von Bahr C, Movin G, Nordin C, Liden A, Hammarlund-Udenaes M, Hedberg A, Ring H, Sjoqvist F (1991) Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype. Clin Pharmacol Ther 49:234–240
Pripp CM, Blomstrom P (1994) Epiglottitis and torsade de pointes tachycardia. Br Heart J 72:205–208
Silva Marques J, Veiga A, Nobrega J, Correia MJ, de Sousa J (2010) Electrical storm induced by H1N1 A influenza infection. Europace 12:294–295
Reinsch N, Buhr C, Krings P, Kaelsch H, Neuhaus K, Wieneke H, Erbel R, Neumann T (2009) Prevalence and risk factors of prolonged QTc interval in HIV-infected patients: results of the HIV-HEART study. HIV Clin Trials 10:261–268
Craft TM (1986) Torsade de pointes after astemizole overdose. Br Med J (Clin Res Ed) 292:660
Monahan BP, Ferguson CL, Killeavy ES, Lloyd BK, Troy J, Cantilena LR Jr (1990) Torsades de pointes occurring in association with terfenadine use. JAMA 264:2788–2790
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nia, A.M., Fuhr, U., Gassanov, N. et al. Torsades de pointes tachycardia induced by common cold compound medication containing chlorpheniramine. Eur J Clin Pharmacol 66, 1173–1175 (2010). https://doi.org/10.1007/s00228-010-0875-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00228-010-0875-5