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Optical spectroscopic methods for intraoperative diagnosis

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Abstract

Molecular analytical methods are increasingly needed for a quick and reliable analysis of tissue in an operating room to provide more information during operations. In this Trends article, we highlight the current state and the developments of optical spectroscopic methods as intra operative tools. The clinical problem and challenges are illustrated on the example of brain tumor surgery. While fluorescence microscopy is already used, vibrational spectroscopy techniques will complement the standard method for brain tissue diagnostics. New portable instruments are currently available and can be stationed in the operating room for quick evaluation of tissue. The promise and limitations of fluorescence and vibrational spectroscopy as intraoperative tools are surveyed in this report.

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Authors and Affiliations

  1. Faculty of Medicine Carl Gustav Carus, Clinical Sensoring and Monitoring, Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany

    Gerald Steiner

  2. Faculty of Medicine Carl Gustav Carus, Department of Neurosurgery, Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany

    Matthias Kirsch

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  1. Gerald Steiner
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  2. Matthias Kirsch
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Correspondence to Gerald Steiner.

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Steiner, G., Kirsch, M. Optical spectroscopic methods for intraoperative diagnosis. Anal Bioanal Chem 406, 21–25 (2014). https://doi.org/10.1007/s00216-013-7401-4

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  • DOI: https://doi.org/10.1007/s00216-013-7401-4

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