Abstract
Summary
Platelets functions are related to bone resorption and formation. The present study aimed at studying the association between platelet function and bone mineralization. We showed that mean platelet volume (MPV) and platelet distribution width (PDW) levels in osteoporosis patients increased. The study also showed that PDW and age independently associated with bone mineralization.
Introduction
MPV and PDW are widely used for assessing platelet function. Recently, authors argued that platelet function has an important role in bone mineralization. However, only one study has investigated the relationship between MPV and osteoporosis. We aimed to study the levels of MPV and PDW in postmenopausal osteoporosis.
Methods
We investigated 320 bone mineral density (BMD) measurements between the years 2012 and 2013 retrospectively in our clinic. Eighty patients whom chronic diseases are absent and all laboratory findings are complete enrolled in this study. Patients were divided in three groups as an osteoporosis, osteopenia, and normal BMD group. MPV and PDW levels were investigated in these groups. We performed correlation test and linear regression analysis to determine whether there is a relationship between platelet function markers and BMD measurements.
Results
Eighty patients were divided as an osteoporosis, osteopenia, and normal BMD group. MPV levels and PDW levels in the osteoporosis group were lower than the normal BMD group. PDW was positively correlated with femur total T (FTT) score and lumbar 1–4T (L1–4T) scores. Linear regression analysis showed that age and PDW were independently related to FTT and LTT scores.
Conclusion
Platelet functions are related to the bone mineralization. PDW and MPV have a significant role in the development of postmenopausal osteoporosis.
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References
Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, Yasuda H, Penninger JM, Toyama Y, Suda T, Miyamoto T (2011) Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med 208:2175–2181
Ciovacco WA, Cheng YH, Horowitz MC, Kacena MA (2010) Immature and mature magakaryocytes enhance osteoblast proliferation and inhibit osteoclast formation. J Cell Biochem 109:774–781
Kacena MA, Ciovacco WA (2010) Megakaryocyte-bone cell interactions. Adv Exp Med Biol 658:31–41
Kacena MA, Nelson T, Clough ME, Lee SK, Lorenzo JA, Gundberg CM, Horowitz MC (2006) Megakaryocyte-mediated inhibition of osteoclast development. Bone 39:991–999
Beeton CA, Bord S, Ireland D, Compston JE (2006) Osteoclast formation and bone resorption are inhibited by megakaryocytes. Bone 39:985–990
D’Amelio P, Cristofaro MA, De Vivo E, Ravazzoli M, Grosso E, Di Bella S, Aime M, Cotto N, Silvagno F, Isaia G, Pescarmona GP (2012) Platelet vitamin D receptor is reduced in osteoporotic patients. Panminerva Med 54:225–231
Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN (2012) The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling. J Clin Invest 122:3579–3592
Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17:47–58
Azab B, Torbey E, Singh J, Akerman M, Khoueiry G, McGinn JT, Widmann WD, Lafferty J (2011) Mean platelet volume/platelet count ratio as a predictor of long-term mortality after non-ST-elevation myocardial infarction. Platelets 22:557–566
Erdem K, Ayhan S, Ozturk S, Bugra O, Bozoglan O, Dursin H, Yazici M, Daglar B (2014) Usefulness of the mean platelet volume for predicting new-onset atrial fibrillation after isolated coronary artery bypass grafting. Platelets 25:23–26
Li XS, Zhang JR, Meng SY, Li Y, Wang RT (2012) Mean platelet volume is negatively associated with bone mineral density in postmenopausal women. J Bone Miner Metab 30:660–665
Liu R, Gao F, Huo J, Yi Q (2012) Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets 23:11–16
De Luca G, Venegoni L, Iorio S, Secco GG, Cassetti E, Verdoia M, Schaffer A, Coppo L, Bellomo G, Marino P, on Behalf of the NOVARA Atherosclerosis Study Group (NAS) (2010) Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets 21:508–514
Kim HL, Cho HY, Park IY, Choi JM, Kim M, Jang HJ, Hwang SM (2011) The positive association between peripheral blood cell counts and bone mineral density in postmenopausal women. Yonsei Med J 52:739–745
Lemieux JM, Horowitz MC, Kacena MA (2010) Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation. J Cell Biochem 109:927–932
Vestergaard P, Steinberg TH, Schwarz P, Jørgensen NR (2012) Use of the oral platelet inhibitors dipyridamole and acetylsalicylic acid is associated with increased risk of fracture. Int J Cardiol 160:36–40
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Akbal, A., Gökmen, F., Gencer, M. et al. Mean platelet volume and platelet distribution width can be related to bone mineralization. Osteoporos Int 25, 2291–2295 (2014). https://doi.org/10.1007/s00198-014-2764-8
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DOI: https://doi.org/10.1007/s00198-014-2764-8