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Interaction of bone morphogenetic proteins with cells of the osteoclast lineage: review of the existing evidence

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Abstract

The present review evaluates the existing scientific proofs of this supplementary role of the BMPs and summarises its clinical implications. Bone regeneration is a process consisting of bone formation and bone resorption, two different but closely coupling pathways, which in most circumstances proceed simultaneously. Plenty of evidence has also characterised the bone morphogenetic proteins (BMPs) as inducing factors of bone formation. However, there is also evidence that these multifunctioning proteins affect bone resorption and the osteoclast homeostasis utilising various pathways. The present review evaluates the existing scientific evidence of this supplementary role of the BMPs, and summarises its clinical implications.

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  1. Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, UK

    P. V. Giannoudis & N. K. Kanakaris

  2. Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA, USA

    T. A. Einhorn

  3. Department of Trauma and Orthopaedics, Academic Unit, Clarendon Wing, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds, LS1 3EX, UK

    P. V. Giannoudis

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  1. P. V. Giannoudis
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  2. N. K. Kanakaris
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  3. T. A. Einhorn
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Correspondence to P. V. Giannoudis.

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Note: This work is attributed to the Academic Unit, Trauma and Orthopaedic Surgery, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK.

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Giannoudis, P.V., Kanakaris, N.K. & Einhorn, T.A. Interaction of bone morphogenetic proteins with cells of the osteoclast lineage: review of the existing evidence. Osteoporos Int 18, 1565–1581 (2007). https://doi.org/10.1007/s00198-007-0441-x

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