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Volume changes and histological response to injected dextranomer/hyaluronic acid copolymer (Zuidex™) and collagen (Contigen®) in rats

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Abstract

The objective of this study was to investigate the stability in terms of volume changes and local tissue reactions of dextranomer (Dx)/hyaluronic acid (HA) and collagen implants. A total of 57 rats were included in this study: the control group (nine rats), collagen-injected group (24 rats), and Dx/HA copolymer-injected group (24 rats). Under anesthesia, 0.35 ml of bulking agents was injected subcutaneously in the abdominal area. At 1, 6, and12 months, eight animals of the two implant groups and three animals of the control group were killed. The area of the injected material and surrounding tissue were carefully resected for histopathological examination. Mean volume changes in the Dx/HA copolymer group were 0.56 ± 0.12, 0.43 ± 0.08, and 0.28 ± 0.02 ml at 1, 6, and 12 months, respectively. Mean volume changes in the collagen group were 0.25 ± 0.03, 0.21 ± 0.08, and 0.21 ± 0.01 at 1, 6, and 12 months, respectively. The degree of tissue reaction and fibrosis are more pronounced in the Dx/HA copolymer group at each measurement period after injection.

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References

  1. Murless B (1938) The injection treatment of stress urinary incontinence. J Obstet Gynaecol Br Emp 45:67–73

    Google Scholar 

  2. Lopez AE, Padron OF, Patsias G, Politano VA (1993) Transurethral polytetrafluoroethylene injection in female patients with urinary continence. J Urol 150:856–858

    PubMed  CAS  Google Scholar 

  3. Politano VA, Small MP, Harper JM, Lynne CM (1974) Periurethral teflon injection for urinary incontinence. J Urol 111:180–183

    PubMed  CAS  Google Scholar 

  4. Malizia AA Jr, Reiman HM, Myers RP et al (1984) Migration and granulomatous reaction after periurethral injection of polytef (Teflon). JAMA 251:3277–3281

    Article  PubMed  Google Scholar 

  5. Henly DR, Barrett DM, Weiland TL, O’Connor MK, Malizia AA, Wein AJ (1995) Particulate silicone for use in periurethral injections: local tissue effects and search for migration. J Urol 153:2039–2043

    Article  PubMed  CAS  Google Scholar 

  6. Dewan PA, Owen AJ, Byard RW (1995) Long-term histological response to subcutaneously injected Polytef and Bioplastique in a rat model. Br J Urol 76:161–164

    PubMed  CAS  Google Scholar 

  7. Shortliffe LM, Freiha FS, Kessler R, Stamey TA, Constantinou CE (1989) Treatment of urinary incontinence by the periurethral implantation of glutaraldehyde cross-linked collagen. J Urol 141:538–541

    PubMed  CAS  Google Scholar 

  8. Stenberg AM, Sundin A, Larsson BS, Lackgren G, Stenberg A (1997) Lack of distant migration after injection of a 125 iodine labeled dextranomer based implant into the rabbit bladder. J Urol 158:1937–1941

    Article  PubMed  CAS  Google Scholar 

  9. Stenberg AM, Larsson G, Johnson P (2003) Urethral injection for stress urinary incontinence: long-term results with dextranomer/hyaluronic acid copolymer. Int Urogynecol J Pelvic Floor Dysfunct 14:335–338

    Article  PubMed  CAS  Google Scholar 

  10. Appell RA (1994) Collagen injection therapy for urinary incontinence. Urol Clin North Am 21:177–182

    PubMed  CAS  Google Scholar 

  11. Appell RA (1990) New developments: injectables for urethral incompetence in women. Int Urogynecol J 1:117–119

    Article  Google Scholar 

  12. Nataluk EA, Assimos DG, Kroovand RL (1995) Collagen injections for treatment of urinary incontinence secondary to intrinsic sphincter deficiency. J Endourol 9:403–406

    Article  PubMed  CAS  Google Scholar 

  13. Monga AK, Stanton SL (1997) Urodynamics: prediction, outcome and analysis of mechanism for cure of stress incontinence by periurethral collagen. Br J Obstet Gynaecol 104:158–162

    PubMed  CAS  Google Scholar 

  14. Frey P, Mangold S (1995) Physical and histological behavior of a new injectable collagen (GAX 65) implanted into the submucosal space of the mini-pig bladder. J Urol 154:812–815

    Article  PubMed  CAS  Google Scholar 

  15. Su TH, Hsu CY, Chen JC (1999) Injection therapy for stress incontinence in women. Int Urogynecol J Pelvic Floor Dysfunct 10:200–206

    Article  PubMed  CAS  Google Scholar 

  16. Corcos J, Fournier C (1999) Periurethral collagen injection for the treatment of female stress urinary incontinence: 4-year follow-up results. Urology 54:815–818

    Article  PubMed  CAS  Google Scholar 

  17. McGuire EJ, English SF (1997) Periurethral collagen injection for male and female sphincteric incontinence: indications, techniques, and result. World J Urol 15:306–309

    Article  PubMed  CAS  Google Scholar 

  18. Maki DD, Banner MP, Ramchandani P, Stolpen A, Rovner ES, Wein AJ (2000) Injected periurethral collagen for postprostatectomy urinary incontinence: MR and CT appearance. Abdom Imaging 25:658–662

    Article  PubMed  CAS  Google Scholar 

  19. Carr LK, Herschorn S, Leonhardt C (1996) Magnetic resonance imaging after intraurethral collagen injected for stress urinary incontinence. J Urol 155:1253–1255

    Article  PubMed  CAS  Google Scholar 

  20. Defreitas GA, Wilson TS, Zimmern PE, Forte TB (2003) Three-dimensional ultrasonography: an objective outcome tool to assess collagen distribution in women with stress urinary incontinence. Urology 62:232–236

    Article  PubMed  Google Scholar 

  21. Stenberg A, Larsson E, Lindholm A, Ronneus B, Stenberg A, Lackgren G (1999) Injectable dextranomer-based implant: histopathology, volume changes and DNA-analysis. Scand J Urol Nephrol 33:355–361

    Article  PubMed  CAS  Google Scholar 

  22. Stenberg A, Larsson E, Lackgren G (2003) Endoscopic treatment with dextranomer-hyaluronic acid for vesicoureteral reflux: histological findings. J Urol 169:1109–1113

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Urology Department, Jewish General Hospital, McGill University, 3755 Côte Sainte-Catherine, Montreal, Quebec, Canada, H3T 1E2

    Ehab A. Elzayat, Gilles Karsenty & Jacques Corcos

  2. Pathology Department, Jewish General Hospital, McGill University, 3755 Côte Sainte-Catherine, Montreal, Quebec, Canada, H3T 1E2

    Tarek A. Bismar

Authors
  1. Ehab A. Elzayat
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  2. Gilles Karsenty
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  3. Tarek A. Bismar
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  4. Jacques Corcos
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Correspondence to Jacques Corcos.

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Elzayat, E.A., Karsenty, G., Bismar, T.A. et al. Volume changes and histological response to injected dextranomer/hyaluronic acid copolymer (Zuidex™) and collagen (Contigen®) in rats. Int Urogynecol J 19, 247–252 (2008). https://doi.org/10.1007/s00192-007-0414-9

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  • DOI: https://doi.org/10.1007/s00192-007-0414-9

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