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Übergewicht und Arthrose

Overweight and osteoarthritis

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Zusammenfassung

Immer mehr Menschen erkranken an einer Osteoarthrose der unterschiedlichen Gelenke. Daraus ergeben sich vielfältige sozioökonomische Probleme.

In verschiedenen epidemiologischen Studien konnte ein Zusammenhang zwischen Gon- bzw. Koxarthrosen und Übergewicht aufgezeigt werden. Die genauen Entstehungsmechanismen der Arthrose sind in diesen Fällen noch unklar, jedoch ist ein multifaktorielles Geschehen zu vermuten: Neben einer im Vordergrund stehenden erhöhten mechanischen Belastung, die zur Knorpelschädigung führt, kann auch ein metabolischer Effekt über biochemische Faktoren wirksam sein. Die Kenntnis der unterschiedlichen Entstehungsmechanismen könnte Ansätze für künftige therapeutische Möglichkeiten bieten.

Abstract

An increasing prevalence and incidence of osteoarthritis especially in aging populations results in different socioeconomic problems. Recent studies have shown an association between osteoarthritis and overweight especially for knee and hip joints. The mechanisms responsible for the destruction of joints are still unknown, however. Obesity and overweight can lead to higher force transmission on joints at least in lower extremities, but mechanical factors hardly explain the association between overweight and hand osteoarthritis shown in different studies. There may be additional metabolic effects responsible for cartilage destruction, but distinct mechanisms have not been demonstrated up to now. They would, however, support preventive measures as well as therapeutic approaches.

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  1. Orthopädische Klinik, Universitätsklinikum Carl Gustav Carus, Technische Universität, Dresden

    A.-F. Groß, S. Fickert &  K. P. Günther

  2. Orthopädische Klinik, Universitätsklinikum Carl Gustav Carus, Technische Universität, Fetscherstraße 74, 01307, Dresden

    K. P. Günther

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  1. A.-F. Groß
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  2. S. Fickert
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  3. K. P. Günther
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Correspondence to K. P. Günther.

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Groß, AF., Fickert, S. & Günther, K.P. Übergewicht und Arthrose. Orthopäde 34, 638–644 (2005). https://doi.org/10.1007/s00132-005-0814-9

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