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Resveratrol und neu synthetisierte Resveratrol-Analoga zur Therapie des Prostatakarzinoms

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Literatur

  1. Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5: 493–506

    Article  PubMed  CAS  Google Scholar 

  2. Bemis DL, Katz AE, Buttyan R (2006) Clinical trials of natural products as chemopreventive agents for prostate cancer. Expert Opin Investig Drugs 15: 1191–200

    Article  PubMed  CAS  Google Scholar 

  3. Aggarwal BB, Bhardwaj A, Aggarwal RS et al. (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24: 2783–2840

    PubMed  CAS  Google Scholar 

  4. Joe AK, Liu H, Suzui M et al. (2002) Resveratrol induces growth inhibition, S phase arrest, apoptosis and changes biomarker expression in several human cancer cell lines. Clin Cancer Res 8: 893–903

    PubMed  CAS  Google Scholar 

  5. Soleas GJ, Grass L, Josephy PD et al. (2006) A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin Biochem 39: 492–497

    Article  PubMed  CAS  Google Scholar 

  6. Providencia R (2006) Cardiovascular protection from alcoholic drinks: scientific basis of the French Paradox. Rev Port Cardiol 25: 1043–1058

    PubMed  Google Scholar 

  7. Ovesna Z, Kozics K, Bader Y et al. (2006) Antioxidant activity of resveratrol, piceatannol and 3,3’,4,4’,5,5’-hexahydroxy-trans-stilbene in three leukemia cell lines. Oncol Rep 16: 617–624

    PubMed  CAS  Google Scholar 

  8. Athar M, Back JH, Tang X et al. (2007) Resveratrol: A review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol (in press)

  9. Ovesna Z, Horvathova-Kozics K (2005) Structure-activity relationship of trans-resveratrol and its analogues. Neoplasma 52: 450–455

    PubMed  CAS  Google Scholar 

  10. Pezutto JM (2004) Resveratrol: a whiff that induces a biologically specific tsunami. Cancer Biol Ther 3: 889–890

    Article  Google Scholar 

  11. Aziz MH, Nihal M, Fu VX et al. (2006) Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3’-kinase/Akt pathway and Bcl-family proteins. Mol Cancer Ther 5: 1335–1341

    Article  PubMed  CAS  Google Scholar 

  12. Liao Z, Mason KA, Milas L (2007) Cyclo-oxygenase-2 and its inhibition in cancer: is there a role? Drugs 67: 821–845

    Article  PubMed  CAS  Google Scholar 

  13. Horvath Z, Murias M, Saiko P et al. (2006) Cytotoxic and biochemical effects of 3,3’,4,4’,5,5’-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells. Exp Hematol 34: 1377–1384

    Article  PubMed  CAS  Google Scholar 

  14. Murias M, Handler N, Erker T et al. (2004) Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571–5578

    Article  PubMed  CAS  Google Scholar 

  15. Benitez DA, Pozo-Guisade E, Alvarez-Barrientos A et al. (2007) Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines. J Androl 28: 282–293

    Article  PubMed  CAS  Google Scholar 

  16. Kampa M, Hatzoglou A, Notas G et al. (2000) Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines. Nutr Cancer 37: 23–33

    Article  Google Scholar 

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Authors and Affiliations

  1. Klinik für Urologie, Universität, Währinger Gürtel 18–20, A-1090, Wien, Österreich

    B. Djavan, S. Marihart, F. Kuehhas & M. Rom

  2. Department of Urology, James Buchanan Institute, Johns Hopkins Hospital, Baltimore, MD, USA

    A. Partin

  3. Department of Cancer Research, Nijmegen, Niederlande

    J. Schalken

  4. Klinik für Labordiagnostik, Wien, Österreich

    T. Sekeres

Authors
  1. B. Djavan
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  2. S. Marihart
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  3. F. Kuehhas
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  4. M. Rom
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  5. A. Partin
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  6. J. Schalken
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  7. T. Sekeres
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Correspondence to B. Djavan.

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Djavan, B., Marihart, S., Kuehhas, F. et al. Resveratrol und neu synthetisierte Resveratrol-Analoga zur Therapie des Prostatakarzinoms. Urologe 46, 1101–1103 (2007). https://doi.org/10.1007/s00120-007-1446-y

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  • DOI: https://doi.org/10.1007/s00120-007-1446-y

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