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Das sinunasale undifferenzierte Karzinom

Ein seltener und aggressiver Tumor der Nasenhaupt- und Nasennebenhöhlen

Sinonasal undifferentiated carcinoma

A rare and aggressive neoplasm of the nasal cavity and paranasal sinuses

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Zusammenfassung

Das sinunasale undifferenzierte Karzinom (SNUC) ist ein 1986 erstmals beschriebener seltener und aggressiver Tumor der Nasenhaupt- und Nasennebenhöhlen. Eine Abgrenzung vom olfaktorischen Neuroblastom kann aufgrund der histomorphologischen Ähnlichkeit der beiden Tumoren schwierig sein. Aufgrund der sehr unterschiedlichen Prognose dieser beiden Malignome ist die exakte Diagnose jedoch von großer Bedeutung. In der vorliegenden Arbeit wird anhand einer Kasuistik über die Bedeutung der Immunhistochemie bei der histologischen Unterscheidung dieser Tumoren berichtet. Ferner liefert die Arbeit eine Übersicht über die in der Literatur beschriebenen möglichen Ursachen für die Entstehung eines undifferenzierten sinunasalen Karzinoms sowie die bestehenden Therapieformen dieser Erkrankung. Trotz aggressiver und multimodaler Therapieschemata haben Patienten mit einem sinunasalen undifferenzierten Karzinom eine schlechte Prognose. Um zu einer einheitlichen und effektiveren Therapieform zu gelangen, ist die Durchführung einer randomisierten und kontrollierten klinischen Studie in der Zukunft erstrebenswert.

Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor of the nasal cavity and paranasal sinuses first described in 1986. Olfactory neuroblastoma and SNUC may appear quite similar on histological examination. Due to the fact that olfactory neuroblastoma has a much better prognosis, a distinction with SNUC has to be drawn. We report a case of SNUC and describe the role of immunohistochemistry in making an accurate histological diagnosis. In addition, potential factors influencing the development of SNUC described in the literature and current treatment modalities are discussed. Despite aggressive and multimodal treatment regimens, the outcomes of patients suffering from SNUC have remained dismal. A randomized controlled clinical study could be the basis for determining the optimal treatment for SNUC.

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Literatur

  1. Mills SE, Gaffey MJ, Frierson HF (2000) Atlas of tumor pathology, tumours of the upper aerodigestive tract and ear. Armed Forces Institute of Pathology, Washington/DC, 3rd series, fascicle 26

  2. Bhattacharyya N, Thornton AF, Joseph MP, Goodman ML, Amrein PC (1997) Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation: Results in 9 cases. Arch Otolaryngol Head Neck Surg 123: 34–40

    PubMed  Google Scholar 

  3. Bush SE, Bagshaw MA (1982) Carcinoma of the paranasal sinuses. Cancer 50: 154–158

    PubMed  Google Scholar 

  4. Cerilli LA, Holst VA, Brandwein MS et al. (2001) Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association. Am J Surg Pathol 25: 156–163

    PubMed  Google Scholar 

  5. Deutsch BD, Levine PA, Stewart FM, Frierson HF Jr, Cantrell RW (1993) Sinonasal undifferentiated carcinoma: A ray of hope. Otolaryngol Head Neck Surg 108: 697–700

    PubMed  Google Scholar 

  6. Frierson HF, Mills SE, Fechner RE, Taxy JB, Levine PA (1986) Sinonasal undifferentiated carcinoma: an aggressive neoplasm derived from schneiderian epithelium and distinct from olfactora neuroblastoma. Am J Pathol 10(11): 771–779

    Google Scholar 

  7. Gallo O, DiLollo S, Graziani P et al. (1995) Detection of Epstein-Barr virus genome in sinonasal undifferentiated carcinoma by use of in situ hybridization. Otolaryngol Head Neck Surg 112: 659–664

    PubMed  Google Scholar 

  8. Gorelick J, Ross D, Marentette L, Blaivas M (2000) Sinonasal undifferentiated carcinoma: Case series and review of the Literature. Neurosurgery 47(3): 750–755

    Article  PubMed  Google Scholar 

  9. Greger V, Schirmacher P, Bohl J, Bornemann A, Hurter T, Passarge E, Horsthemke B (1990) Possible involvement of the retinoblastoma gene in undifferentiated sinonasal carcinoma. Cancer 66: 1954–1959

    PubMed  Google Scholar 

  10. Helliwell TR, Yeoh LH, Stell PM (1986) Anaplastic carcinoma of the nose and paranasal sinuses. Light microscopy, immunohistochemistry and clinical correlation. Cancer 58: 2038–2045

    PubMed  Google Scholar 

  11. Hirose T, Scheithaurer BW, Lopes MBS et al. (1995) Olfactory neuroblastoma: an immunohistochemical, ultrastructural, and flow cytometric study. Cancer 76(1): 4–19

    PubMed  Google Scholar 

  12. Irish J, Dasgupta R, Freeman J et al. (1997) Outcome and analysis of the surgical management of esthesioneuroblastoma. J Otolaryngol 26: 1–7

    PubMed  Google Scholar 

  13. Jeng YM, Sung MT, Fang CL, Huang HY, Mao TL, Cheng W, Hsiao CH (2002). Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically and histopathologically distinct entities. Am J Surg Pathol 26(3): 371–376

    Article  PubMed  Google Scholar 

  14. Leung SY, Yuen ST, Chung LP et al. (1995) Epstein-Barr virus is present in a wide histological spectrum of sinonasal carcinomas. Am J Surg Pathol 19: 994–1001

    PubMed  Google Scholar 

  15. Levine PA, Frierson HF Jr, Stewart FM, Mills E, Fechner RE, Cantrell RW (1987) Sinonasal undifferentiated carcinoma: A distinctive and highly aggressive neoplasm. Laryngoscope 97: 905–908

    PubMed  Google Scholar 

  16. Lopategui JR, Gaffey MJ, Frierson HF et al. (1994) Detection of Epstein-Barr viral RNA in sinonasal undifferentiated carcinoma from Western and Asian Patients. Am J Surg Pathol 18: 391–398

    PubMed  Google Scholar 

  17. Musy PY, Reibel JF, Levine PA (2002) Sinonasal undifferentiated carcinoma: the search for a better outcome. Laryngoscope 112(8): 1450–1455

    Article  PubMed  Google Scholar 

  18. Pitman K, Constantino P, Lassen L (1995) Sinonasal undifferentiated carcinoma: Current trends in treatment. Skull Base Surg 5: 269–272

    Google Scholar 

  19. Polin RS, Sheehan JP, Chenelle AG et al. (1998) The role of preoperative adjuvant treatment in the management of esthesioneuroblastoma: The University of Virginia experience. Neurosurgery 42: 1029–1397

    Article  PubMed  Google Scholar 

  20. Sisson GA, Toriumi DM, Atiyah RA et al. (1989) Paranasal sinus malignancy: a comprehensive update. Laryngoscope 99: 143–150

    PubMed  Google Scholar 

  21. Smith SR, Som P, Fahmy A, Lawson W, Sacks S, Brandwein M (2000) A clinicopathological study of sinonasal neuroendocrine carcinoma and sinonasal undifferentiated carcinoma. Laryngoscope 110(10 Pt 1): 1617–1622

    Article  PubMed  Google Scholar 

  22. Stewart FM, Lazarus HM, Levine PA, Stewart KA, Tabbara IA, Spaulding CA (1989) High-dose chemotherapy and autologous marrow transplantation for esthesioneuroblastoma and sinonasal undifferentiated carcinoma. Am J Clin Oncol 12(3): 217–221

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Ludwig-Maximilians-Universität München

    O. Reichel, F. Born, M. Andratschke, G. Rasp & H. Hagedorn

  2. Pathologisches Institut der Ludwig-Maximilians-Universität München

    S. Ihrler

  3. Klinik für Hals-, Nasen- und Ohrenheilkunde, Ludwig-Maximilians-Universität München — Klinikum Großhadern, Marchioninistraße 15, 81377, München

    O. Reichel

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  1. O. Reichel
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  2. S. Ihrler
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  3. F. Born
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  4. M. Andratschke
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  5. G. Rasp
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  6. H. Hagedorn
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Correspondence to O. Reichel.

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Reichel, O., Ihrler, S., Born, F. et al. Das sinunasale undifferenzierte Karzinom. HNO 54, 394–399 (2006). https://doi.org/10.1007/s00106-005-1299-x

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  • DOI: https://doi.org/10.1007/s00106-005-1299-x

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