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Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation

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Abstract

The ubiquitin–proteasome pathway of protein degradation is one of the major mechanisms that are involved in the maintenance of the proper levels of cellular proteins. The regulation of proteasomal degradation thus ensures proper cell functions. The family of proteins containing ubiquitin-like (UbL) and ubiquitin-associated (UBA) domains has been implicated in proteasomal degradation. UbL–UBA domain containing proteins associate with substrates destined for degradation as well as with subunits of the proteasome, thus regulating the proper turnover of proteins.

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Acknowledgments

We would like to thank Dr. Mervyn Monteiro for helpful comments on the manuscript. Work by V.S. and A.F.L. is supported by grant CA052098 from the National Cancer Institute, National Institutes of Health.

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Authors and Affiliations

  1. Natural Products and Cancer Biology Program, Cancer Research Center, University of Hawaii at Manoa, 651 Ilalo Street, BSB 222, Honolulu, HI, 96813, USA

    Vivian Su & Alan F. Lau

  2. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street, BSB 222L, Honolulu, HI, 96813, USA

    Alan F. Lau

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  1. Vivian Su
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Correspondence to Vivian Su.

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Su, V., Lau, A.F. Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation. Cell. Mol. Life Sci. 66, 2819–2833 (2009). https://doi.org/10.1007/s00018-009-0048-9

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  • DOI: https://doi.org/10.1007/s00018-009-0048-9

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