Skip to main content

Advertisement

SpringerLink
Log in

Phosphinic peptides as zinc metalloproteinase inhibitors

  • Review
  • Published:
Cellular and Molecular Life Sciences CMLS Aims and scope Submit manuscript

Abstract

Solid-phase synthesis of phosphinic peptides was introduced 10 years ago. A major application of this chemistry has been the development of potent synthetic inhibitors of zinc metalloproteases. Specific properties of the inhibitors produced in recent years are reviewed, supporting the notion that phosphinic pseudo-peptides are useful tools for studying the structural and functional biology of zinc proteases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Départment d’Ingénierie et d’Etudes des Protéines (DIEP), CEA, CE-Saclay, 91191, Gif/Yvette Cedex, France

    V. Dive, F. Beau & P. Cuniasse

  2. Department of Organic Chemistry, Laboratory of Organic Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens, Greece

    D. Georgiadis, M. Matziari, A. Makaritis & A. Yiotakis

Authors
  1. V. Dive
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Georgiadis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Matziari
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Makaritis
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Beau
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Cuniasse
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. Yiotakis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. Dive.

Additional information

Received 3 February 2004; received after revision 4 March 2004; accepted 16 March 2004

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dive, V., Georgiadis, D., Matziari, M. et al. Phosphinic peptides as zinc metalloproteinase inhibitors. CMLS, Cell. Mol. Life Sci. 61, 2010–2019 (2004). https://doi.org/10.1007/s00018-004-4050-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-004-4050-y

Search

Navigation