Abstract
Objective: The effect of bradykinin (B1 or B2) receptor antagonists was studied in allergic and immune-complex-induced lung inflammation.
Methods: Lungs of BALB/c mice were examined 24 h after induction of lung inflammation, either allergic (ovalbumin-sensitized submitted to two aerosol of antigen, one week apart) or immune-complex induced (intratracheal instillation of IgG antibodies followed by intravenous antigen). The bradykinin B2 receptor antagonist, HOE-140 or bradykinin B1 receptor antagonist, R-954 were given intraperitoneally (100 μg/kg), 30 min before induction.
Results: In allergic inflammation, pre-treatment with R-954 reduced eosinophil infiltration into the lungs, mucus secretion and the airway hyperreactivity to methacholine. Pre-treatment with HOE-140 increased eosinophil infiltration but did not affect the other parameters. In immune-complex inflammation, HOE-140 increased neutrophil infiltration but not their activation nor the hemorrhagic lesions. R-594 pre-treatment did not change the parameters examined.
Conclusion: These results show important modulatory effects of bradykinin B1 and B2 receptor antagonists in both models of lung inflammation.
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Received 6 May 2003; returned for revision 22 July 2003; accepted by N. Boughton-Smith 8 October 2003Received 6 May 2003; returned for revision 22 July 2003; accepted by N. Boughton-Smith 8 October 2003
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Gama Landgraf, R., Jancar, S., Steil, A.A. et al. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Inflamm. res. 53, 78–83 (2004). https://doi.org/10.1007/s00011-003-1226-0
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DOI: https://doi.org/10.1007/s00011-003-1226-0