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Studies on interactions between traditional herbal and western medicines. IV: Lack of pharmacokinetic interactions between Saiko-ka-ryukotsu-borei-to and carbamazepine in rats

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Summary

The possibility of pharmacokinetic interactions between Saiko-ka-ryukotsu-borei-to extract powder (TJ-12), a widely used traditional Chinese herbal (Kampo) medicine, and carbamazepine (CBZ), an important anti-epileptic drug, was examined in rats. There were no significant differences in the serum protein binding of CBZ and carbamazepine-10, 11-epoxide (CBZ-E), its active metabolite, at two concentrations (1 and 10 Bg/ml) between two groups pretreated orally with the vehicle and TJ-12 suspension (1 g/kg/d, p.o.) for 1 week. One-week repeated pretreatment with TJ-12 (1 g/kg/d) did not influence liver weight, contents of cytochromes P450 and b5 in hepatic microsomes or the formation rate of CBZ-E from CBZ by its microsomes, while pretreatment with phenobarbital (80 mg/kg/d, i.p.) significantly increased these paramenters. Neither a single nor 1-week repeated oral pretreatment with TJ-12 (1 g/kg/d) affected the plasma concentration-time profile and any pharmacokinetic parameter of CBZ or CBZ-E after oral administration of CBZ (50 mg/kg). These results indicated that oral co-administration of TJ-12 with CBZ has no effect of the pharmacokinetics of CBZ or CBZ-E in rats. Concomitant treatment with TJ-12 and CBZ appears to be pharmacokinetically safe in humans.

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Author notes

  1. Noriaki Ohnishi Ph.D.

    Present address: Department of Environmental Biochemistry, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan

Authors and Affiliations

  1. Department of Pharmacy, Takarazuka City Hospital, Takarazuka, Japan

    Mutsunobu Yoshioka & Kazuo Kuroda

  2. Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashinaku, 607-8414, Kyoto, Japan

    Noriaki Ohnishi Ph.D., Shiniji Nakasako, Kazuya Okada, Sachiko Umehara, Koji Takara, Kazuki Nagasawa & Teruyoshi Yokoyama

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  1. Noriaki Ohnishi Ph.D.
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  2. Shiniji Nakasako
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Ohnishi, N., Nakasako, S., Okada, K. et al. Studies on interactions between traditional herbal and western medicines. IV: Lack of pharmacokinetic interactions between Saiko-ka-ryukotsu-borei-to and carbamazepine in rats. Eur. J. Drug Metab. Pharmacokinet. 26, 129–135 (2001). https://doi.org/10.1007/BF03190386

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  • DOI: https://doi.org/10.1007/BF03190386

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