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The effect of midazolam on median nerve somatosensory evoked potentials

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Abstract

Objective. To quantify the effect of an induction dose of midazolam on median nerve somatosensory evoked potentials.Methods. We studied 10 patients undergoing lumbar spine surgery. After an induction dose of intravenous midazolam was given, MNEPs were collected for ten minutes. After ten minutes the patients were intubated and their anesthetic was supplemented with 0.5% isoflurane, narcotic, and N2O.Results. We found a clinically significant decrease in amplitude and an insignificant delay in latency.Conclusion. When midazolam is used as an anesthetic induction agent, a decrease in amplitude can be expected.

Resume

Objectif. Quantification des effets d’une doses d’induction de midazolam sur les potentiels evoques somatosensitifs du nerf médian (PESNM).Méthodes. Nous avons etudies 10 malades operes de l’épine dorsale lombaire. Aprés une induction intraveineuse au midazolam, les PESNM furent recueillis pour 10 minutes. Par apres, les malades regurent une intubation tracheale et leur anesthesic fut supplee à Paide de 0.5% d’isoflurane, de narcotiques et de protoxide d’azote.Resultats. Nous avons trouvé une diminution cliniquement significative de l’amplitude et une prolongation insignifiante de la latence des PESNM.Conclusion. Lors de l’emploi du midazolam comme agent d’induction, Ton peut s’attendre à une réduction de l’amplitude des PESNM.

Abstrakt

Ziel. Quantifizierung des Effektes einer Midazolam-Induktionsdosis auf die somatosensorisch evozierten Potentiale des N. medianus.Methoden. Wir untersuchten 10 Patienten, die sich einer Operation im lumbalen Wirbelsäulenbereich unterzogen. Nach einer Induktionsdosis Midazolam i.v. wurden SSEP vom N. medianus fur 10 min gesammelt. Nach 10 min wurden die Patienten intubiert, und die Narkose wurde supplementiert mit 0.5 Vol% Isoflurane, Narkotika und N20.Ergebnisse. Wir fanden eine klinisch signifikante Abnahme der Amplitude und eine nicht signifikante Verlängerung der Latenzzeit.Folgerung. Wenn Midazolam als Einleitungsanästhetikum benutzt wird, kann eine Abnahme der Amplitude erwartet werden.

Resumen

Objetivo. Cuantificar el efecto de una dosis de induccion de midazolam sobre los potenciales somatosensoriales evocados del nervio mediano (PENV).Metodos. Estudi amos 10 pacientes sometidos a cirugia sobre la columna lumbar. Una vez administrada una dosis de induccion de midazolam intravenoso, se coleccionaron PENV durante diez minutos. Transcurridos los diez minutos los pacientes fueron intubados y su anestesia fue suplementada con 0.5% de isofluorano, narcótico y N20.Resultados. Encontramos una disminucion significativa de la amplitud y un retardo no significativo de la latencia.Conclusión. Cuando se usa midazolam como agente de induccion, debe esperarse una disminución de la amplitud de PENV.

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Lauer, K., Munshi, C. & Larson, S. The effect of midazolam on median nerve somatosensory evoked potentials. J Clin Monitor Comput 10, 181–184 (1994). https://doi.org/10.1007/BF02908858

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  • DOI: https://doi.org/10.1007/BF02908858

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