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Bio-rational design of photosystem II inhibitors (VIII)

Molecular design, synthesis and inhibitory activity of acrylates (acrylamides)

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Abstract

Molecular modeling of acrylates (acrylamides) with Dl protein ofPisum sativum is presented. Studies show that the binding force mainly includes H-bond interaction, Van der Waals and π-ring stacking interaction. It was found that SER 268 in Dl protein might be an important binding site. It is important for high inhibitory activity of compounds whether an electronegative atom in alkyl of ester linkage could make H-bond interaction with SER 268 in Dl protein. Thus some new acrylates (acrylamides) were designed and synthesized. Bioassay indicated that these new compounds showed expected Hill reaction inhibitory activity.

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Authors and Affiliations

  1. State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071, Tianjin, China

    Huayin Liu, Yinlin Sha, Huifen Tan & Huazheng Yang

  2. National State and Unstate Structure Laboratory, Institute of Physical Chemistry, Peking University, 100871, Beijing, China

    Luhua Lai

Authors
  1. Huayin Liu
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  2. Yinlin Sha
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  3. Huifen Tan
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  4. Huazheng Yang
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  5. Luhua Lai
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Additional information

Project supported by the National Natural Science Foundation of China (Grant No. 29702006) and the special fund of Nature Science of Tianjin.

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Liu, H., Sha, Y., Tan, H. et al. Bio-rational design of photosystem II inhibitors (VIII). Sc. China Ser. B-Chem. 42, 326–331 (1999). https://doi.org/10.1007/BF02874250

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  • DOI: https://doi.org/10.1007/BF02874250

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