Summary
Bone cement is sometimes used for vertebral body reconstruction following tumor removal. During such procedures, the polymerization of the methyl-metacrylate in the bone cement generates heat. Such temperature increase might cause damage to the nerve roots within the spinal canal. In the present study, pig cauda equina nerve roots were subjected to controlled temperature increases by means of a heat-generating probe. A temperature of 40°C applied for 5 min did not cause any changes in nerve root function. However, 70°C resulted in a complete block of nerve root function within 5 min. Histological nerve fiber damage was seen after exposure to 60°C and 70°C. The present study provides basic knowledge of heat-resistance properties of spinal nerve roots that might be directly applicable as guidelines for safety margins during surgical spine reconstruction procedures using bone cement.
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References
Hansebout RR, Blomqvist JA Jr (1980) Acrylic spinal fusion. J Neurosurg 53:606–612
Karnovsky MJ (1965) A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J Cell Biol 27:137A
Lundskog J (1972) Heat and bone tissue. An experimental investigation of the thermal properties of bone tissue and threshold levels for thermal injury. Thesis, University of Gothenburg
Mjöberg B (1986) Loosening of the cemented hip prosthesis. The importance of heat injury. Acta Orthop Scand 57 [Suppl 21]
Olmarker K, Rydevik B, Nordborg C (1993) Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots. Spine 18:11:1425–1432
Richardson KC, Jarett L, Finke EH (1960) Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol 35:313–323
Siegal T, Tiqva P, Siegal T (1985) Vertebral body resection for epidural compression by malignant tumors. J Orthop Res 67A:375–382
Stener B (1989) Complete removal of vertebrae for extirpation of tumors. Clin Orthop 245:72–82
Toksvig-Larsen S, Johnsson R, Strömqvist B (1994) Heat generation and heat protection in methylmethacrylate cementation of vertebral bodies. Eur Spine J (in press)
Uchiyama S, Yashiro K, Takahashi H, Homma T (1989) An experimental study of spinal cord evoked potentials and histologic changes following spinal cord healing. Spine 14:1215–1219
Wilkes R, Mackinnon J, Thoma W (1994) Neurological deterioration after cement injection into a vertebral body. J Bone Joint Surg 76 B:155
Yokota M, Masuhara K, Iwasaki H, Kamihara K, Ishii M, Fuji S (1982) A study of thermal effect on spinal cord. Centr Jpn J Orthop Traumatol 24:1235–1237
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Konno, S., Olmarker, K., Byröd, G. et al. Acute thermal nerve root injury. Eur Spine J 3, 299–302 (1994). https://doi.org/10.1007/BF02200140
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DOI: https://doi.org/10.1007/BF02200140